Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

Chiodo, Louis A.; Bannon, Michael J.; Roth, Robert H.; Bunney, Benjamin S.

doi:10.1016/0306-4522(84)90133-7

Cited by 296 publications

(201 citation statements)

References 47 publications

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“…While interactions exist between the mesocortical and mesostriatal DA systems (Jenner, 2002), we do not consider there to be a direct relationship between activation of midbrain autoreceptors and DA levels in the cortex since there is a lack of somatodendritic autoreceptors on mesocortical projection fibres (Chiodo et al, 1984). Rather, differences in autoreceptor sensitivity in the midbrain impact only on mesostriatal and mesolimbic DA.…”

Section: Discussion [11c] Flb-457 Bp In the Midbrainmentioning

confidence: 95%

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Ray

Miyasaki

Zurowski

et al. 2012

Neurobiology of Disease

119

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Impulse control disorders such as pathological gambling (PG) are a serious and common adverse effect of dopamine (DA) replacement medication in Parkinson's disease (PD). Patients with PG have increased impulsivity and abnormalities in striatal DA, in common with behavioural and substance addictions in the non-PD population. To date, no studies have investigated the role of extrastriatal dopaminergic abnormalities in PD patients with PG. We used the PET radiotracer, [11C] FLB-457, with high-affinity for extrastriatal DA D2/3 receptors. 14 PD patients on DA agonists were imaged while they performed a gambling task involving real monetary reward and a control task. Trait impulsivity was measured with the Barratt Impulsivity Scale (BIS). Seven of the patients had a history of PG that developed subsequent to DA agonist medication. Change in [11C] FLB-457 binding potential (BP) during gambling was reduced in PD with PG patients in the midbrain, where D2/D3 receptors are dominated by autoreceptors. The degree of change in [11C] FLB-457 binding in this region correlated with impulsivity. In the cortex, [11C] FLB-457 BP was significantly greater in the anterior cingulate cortex (ACC) in PD patients with PG during the control task, and binding in this region was also correlated with impulsivity. Our findings provide the first evidence that PD patients with PG have dysfunctional activation of DA autoreceptors in the midbrain and low DA tone in the ACC. Thus, altered striatal and cortical DA homeostasis may incur vulnerability for the development of PG in PD, linked with the impulsive personality trait.

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Section: Discussion [11c] Flb-457 Bp In the Midbrainmentioning

confidence: 95%

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Ray

Miyasaki

Zurowski

et al. 2012

Neurobiology of Disease

119

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“…The high basal firing rate (Chiodo et al 1984;White and Wang 1984) and the large fraction of activated TH (Iuvone and Dunn 1986) of mesocortical DA neurons suggested that precursor dependence might be a nor- (Bradberry et al 1989;Tam et al 1990), increases in MPFC DA synthesis after administration of exogenous tyrosine appeared to be modest and highly transient (Tam et al 1990). However, exogenous tyrosine administration robustly increased MPFC DA synthesis after pretreatment with FG-7142, an inverse benzodiazepine agonist which preferentially increases MPFC DA synthesis and release (Tam et al 1990;Bradberry et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, changes in DA synthesis do not necessarily result in changes in DA release (Westerink et al 1982: Westerink andWirix 1983). Accordingly, the later report by During et al (1989) that tyrosine administration augmented the haloperidol-induced increase in striatal dialysate DA concentrations as measured by in vivo microdialysis (albeit in anesthetized animals) provided critical support for the possible functional importance of precursor dependence in DA systems.The high basal firing rate (Chiodo et al 1984;White and Wang 1984) and the large fraction of activated TH (Iuvone and Dunn 1986) of mesocortical DA neurons suggested that precursor dependence might be a nor- While several groups demonstrated that experimental reductions in brain tyrosine concentrations reduced MPFC DA synthesis as measured in vivo (Bradberry et al 1989;Tam et al 1990), increases in MPFC DA synthesis after administration of exogenous tyrosine appeared to be modest and highly transient (Tam et al 1990). However, exogenous tyrosine administration robustly increased MPFC DA synthesis after pretreatment with FG-7142, an inverse benzodiazepine agonist which preferentially increases MPFC DA synthesis and release (Tam et al 1990;Bradberry et al 1991).…”

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confidence: 99%

“…Since mesocortical DA neurons have the highest basal electrophysiological activity of all central DA systems (Chiodo et al 1984;White and Wang 1984), precursor dependence of medial prefrontal cortical (MPFC) DA synthesis might be expected even under basal conditions. Even within the MPFC, however, tight feedback systems limit the ability of exogenous tyrosine administration to augment DA synthesis (Tam et al 1990).…”

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confidence: 99%

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Tyrosine Augments Acute Clozapine- but not Haloperidol-Induced Dopamine Release in the Medial Prefrontal Cortex of the Rat An in vivo Microdialysis Study

Jaskiw

Collins

Pehek

et al. 2001

Neuropsychopharmacology

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Tyrosine availability can influence dopamine (DA) synthesis in highly electrophysiologically active DAergic neurons, such as those innervating the medial prefrontal cortex (MPFC).In most brain dopamine (DA) systems, levels of the DA precursor tyrosine do not significantly affect dopaminergic transmission. The availability of tyrosine in the brain normally exceeds the capacity of the enzyme tyrosine hydroxylase (TH) to convert it to DOPA (Carlsson and Lindqvist 1978;Morgenroth et al. 1976;Joh et al. 1978). Since the conversion of DOPA to DA is rapid and efficient, DA synthesis usually depends on TH activity and not on tyrosine levels (Wurtman et al. 1974;Carlsson and Lindqvist 1978). However, precursor dependence of DA synthesis has been demonstrated in the light-activated retina (Fernstrom et al. 1984(Fernstrom et al. , 1986 as well as in striatal DA neurons after administration of haloperidol, spiperone, reserpine or amfonelic acid (Scally et al. 1977;Sved et al. 1979;Fuller and Snoddy 1982) or after marked DA depletion (Melamed et al. 1980). The common feature of these paradigms is a marked increase in the electrophysiological activity of the relevant DA system. Such data suggest that precursor dependence of DA synthesis may be a latent property of all DA neurons, but one which emerges only under conditions of increased dopaminergic activity. (Chiodo et al. 1984;White and Wang 1984), precursor dependence of medial prefrontal cortical (MPFC) DA synthesis might be expected even under basal conditions. Even within the MPFC, however, tight feedback systems limit the ability of exogenous tyrosine administration to augment DA synthesis (Tam et al. 1990). Intriguingly, in rats pretreated with FG-7142, a beta-carboline known to preferentially increase MPFC synthesis, utilization and release Roth 1985, 1990;Bradberry et al. 1991), administration of tyrosine robustly enhances MPFC DA synthesis (Tam et al. 1990). We postulated that such precursor dependence would also be established by other drugs which activate mesocortical dopaminergic activity.The atypical and clinically superior antipsychotic drug, clozapine, has already been demonstrated to preferentially release DA in the prefrontal cortex of the rat (Moghaddam and Bunney 1990; Pehek and Yamamoto 1994;Yamamoto and Cooperman 1995) as well as of the non-human primate (Youngren et al. 1999) and to preferentially activate DA neurons projecting to cortical regions (White and Wang 1983;Goldstein et al. 1993). Accordingly, we postulated that the co-administration of tyrosine and clozapine would potentiate MPFC DA synthesis. We further postulated that if the increased DA synthesis were reflected in increased DA release, then administration of tyrosine to clozapine-pretreated rats would augment MPFC DA levels as measured by in vivo microdialysis. Finally, since haloperidol, but not clozapine, preferentially activates nigrostriatal DA synthesis and release, we anticipated that tyrosine would enhance dialysate DA concentrations in the striatum but not the MPFC of haloperi...

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“…Compared to many studies, in which DA cells were recorded from the substantia nigra pars compacts (SNc) or a lateral segment of the VTA, most of our cells were recorded from its medial portion (see Fig. 1), where the fast-firing mesocortical cells are preferentially located (Chiodo et al 1984). However, several recent studies questioned the traditional criteria of indirect DA cell identification as less reliable and absolute than was originally thought (Ungless et al, 2004;Margolis et al, 2006).…”

Section: Vta Cell Heterogeneity and The Issue Of Neuronal Phenotypementioning

confidence: 89%

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

Brown

Kiyatkin

2008

Brain Research

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Intravenous (iv) cocaine mimics salient somato-sensory stimuli in their ability to induce rapid physiological effects, which appear to involve its action on peripherally located neural elements and fast neural transmission via somato-sensory pathways. To further clarify this mechanism, single-unit recording with fine glass electrodes was used in awake rats to examine responses of ventral tegmental area (VTA) neurons, both presumed dopamine (DA) and non-DA, to iv cocaine and tail-press, a typical somato-sensory stimulus. To exclude the contribution of DA mechanisms to the observed neuronal responses to sensory stimuli and cocaine, recordings were conducted during full DA receptor blockade (SCH23390+eticloptide).Iv cocaine (0.25 mg/kg delivered over 10 s) induces significant excitations of ~63% of long-spike (presumed DA) and ~70% of short-spike (presumed non-DA) VTA neurons. In both subgroups, neuronal excitations occurred with short latencies (4-8 s), peaked at 10-20 s (30-40% increase over baseline) and disappeared at 30-40 s after the injection onset. Most long-(67%) and short-spike (89%) VTA neurons also showed phasic responses to tail-press (5-s). All responsive long-spike cells were excited by tail-press; excitations were very rapid (peak at 1 s) and strong (100% rate increase over baseline) but brief (2-3 s). In contrast, both excitations (60%) and inhibitions (29%) were seen in short-spike cells. These responses were also rapid and transient, but excitations of short-spike units were more prolonged and sustained (10-15 s) than in long-spike cells.These data suggest that in awake animals iv cocaine, like somato-sensory stimuli, rapidly and transiently excites VTA neurons of different subtypes. Therefore, along with direct action on specific brain substrates, central effects of cocaine may occur via indirect mechanism, involving peripheral neural elements, visceral sensory nerves and rapid neural transmission. Via this mechanism, cocaine, like somato-sensory stimuli, can rapidly activate DA neurons and induce phasic DA release, creating the conditions for DA accumulation by a later occurring and prolonged direct inhibiting action on DA uptake. By providing a rapid neural signal and triggering transient neural activation, such a peripherally driven action might play a crucial role in the sensory effects of COC, thus contributing to learning and development of drug-taking behavior.

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Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

Cited by 296 publications

References 47 publications

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

Tyrosine Augments Acute Clozapine- but not Haloperidol-Induced Dopamine Release in the Medial Prefrontal Cortex of the Rat An in vivo Microdialysis Study

Sensory effects of intravenous cocaine on dopamine and non-dopamine ventral tegmental area neurons

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