Evidence for rem sleep deprivation as the mechanism of action of antidepressant drugs

Sleep Deprivation Is a Less Potent Agent than Clomipramine in Increasing Firing Rate in Lateral Septal Neurons in the Rat

“…There fore. results do not support the assumption of sleep depri vation as an exclusive mechanism of action of antidepres sants [6], but rather arc in agreement with other reports claiming separated actions of antidepressants from sleep suppression [20][21][22], In conclusion. CMI is a more potent agent in produc ing changes in firing rate in lateral septal neurons than sleep deprivation, and changes in firing rate produced by sleep deprivation do not seem cumulative after extended treatment.…”

“…A requisite for maintaining an enhanced REM pres sure for clinical improvement has been pointed out [6,13], In the present study, neither the control group nor the SD-12 group showed changes in firing rate in their lateral septal neurons. The common procedure in these groups consisted in allowing 24 h in normal housing cages.…”

Sleep Deprivation Is a Less Potent Agent than Clomipramine in Increasing Firing Rate in Lateral Septal Neurons in the Rat

“…There fore. results do not support the assumption of sleep depri vation as an exclusive mechanism of action of antidepres sants [6], but rather arc in agreement with other reports claiming separated actions of antidepressants from sleep suppression [20][21][22], In conclusion. CMI is a more potent agent in produc ing changes in firing rate in lateral septal neurons than sleep deprivation, and changes in firing rate produced by sleep deprivation do not seem cumulative after extended treatment.…”

“…A requisite for maintaining an enhanced REM pres sure for clinical improvement has been pointed out [6,13], In the present study, neither the control group nor the SD-12 group showed changes in firing rate in their lateral septal neurons. The common procedure in these groups consisted in allowing 24 h in normal housing cages.…”

Two types of REM sleep: The atonic and brain REM sleep

“…In contrast, the REM sleep tends to disrupt the emotional balance toward depression (Goldstein & Walker, 2014;Palagini et al, 2013). REM sleep deprivation was reported as therapeutic against depression in humans (Vogel, 1975;1983) and ameliorative against fear in rats (Hicks & Moore, 1979). All these results clearly demonstrated that SWS and REM sleep manifested opposite and counteractive in emotional regulation.…”

Antidepressant effects of selective slow wave sleep deprivation in major depression: A high-density EEG investigation

“…Supporting the REMD literature and the REM sleep-suppressing action of many antidepressant medications (Vogel, 1983), lower amounts of REM sleep (relative to TST) were correlated with a greater reduction in depressive symptom ratings. Given this unexpected finding, it is possible that a combined SWD and REMD intervention may be particularly beneficial for alleviating depressive symptomatology.…”

Sleep Deprivation Is a Less Potent Agent than Clomipramine in Increasing Firing Rate in Lateral Septal Neurons in the Rat

“…There fore. results do not support the assumption of sleep depri vation as an exclusive mechanism of action of antidepres sants [6], but rather arc in agreement with other reports claiming separated actions of antidepressants from sleep suppression [20][21][22], In conclusion. CMI is a more potent agent in produc ing changes in firing rate in lateral septal neurons than sleep deprivation, and changes in firing rate produced by sleep deprivation do not seem cumulative after extended treatment.…”

“…A requisite for maintaining an enhanced REM pres sure for clinical improvement has been pointed out [6,13], In the present study, neither the control group nor the SD-12 group showed changes in firing rate in their lateral septal neurons. The common procedure in these groups consisted in allowing 24 h in normal housing cages.…”

Two types of REM sleep: The atonic and brain REM sleep

“…In contrast, the REM sleep tends to disrupt the emotional balance toward depression (Goldstein & Walker, 2014;Palagini et al, 2013). REM sleep deprivation was reported as therapeutic against depression in humans (Vogel, 1975;1983) and ameliorative against fear in rats (Hicks & Moore, 1979). All these results clearly demonstrated that SWS and REM sleep manifested opposite and counteractive in emotional regulation.…”

Antidepressant effects of selective slow wave sleep deprivation in major depression: A high-density EEG investigation

“…Supporting the REMD literature and the REM sleep-suppressing action of many antidepressant medications (Vogel, 1983), lower amounts of REM sleep (relative to TST) were correlated with a greater reduction in depressive symptom ratings. Given this unexpected finding, it is possible that a combined SWD and REMD intervention may be particularly beneficial for alleviating depressive symptomatology.…”

Sleep Deprivation Is a Less Potent Agent than Clomipramine in Increasing Firing Rate in Lateral Septal Neurons in the Rat

“…There fore. results do not support the assumption of sleep depri vation as an exclusive mechanism of action of antidepres sants [6], but rather arc in agreement with other reports claiming separated actions of antidepressants from sleep suppression [20][21][22], In conclusion. CMI is a more potent agent in produc ing changes in firing rate in lateral septal neurons than sleep deprivation, and changes in firing rate produced by sleep deprivation do not seem cumulative after extended treatment.…”

“…A requisite for maintaining an enhanced REM pres sure for clinical improvement has been pointed out [6,13], In the present study, neither the control group nor the SD-12 group showed changes in firing rate in their lateral septal neurons. The common procedure in these groups consisted in allowing 24 h in normal housing cages.…”

Two types of REM sleep: The atonic and brain REM sleep

“…In contrast, the REM sleep tends to disrupt the emotional balance toward depression (Goldstein & Walker, 2014;Palagini et al, 2013). REM sleep deprivation was reported as therapeutic against depression in humans (Vogel, 1975;1983) and ameliorative against fear in rats (Hicks & Moore, 1979). All these results clearly demonstrated that SWS and REM sleep manifested opposite and counteractive in emotional regulation.…”

Antidepressant effects of selective slow wave sleep deprivation in major depression: A high-density EEG investigation

“…Supporting the REMD literature and the REM sleep-suppressing action of many antidepressant medications (Vogel, 1983), lower amounts of REM sleep (relative to TST) were correlated with a greater reduction in depressive symptom ratings. Given this unexpected finding, it is possible that a combined SWD and REMD intervention may be particularly beneficial for alleviating depressive symptomatology.…”