Evidence for norepinephrine-activated Ca2+ permeable channels in guinea-pig hepatocytes using a patch clamp technique.

Nagano, Tomoo; Satō, Ryōichi; Matsuda, Hiroyuki; Aramaki, Takumi

doi:10.1272/jnms.66.127

Cited by 1 publication

(2 citation statements)

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“…In the present study, the results (Figure 1) Figure 1D), and also to increase PLC activity ( Figure 8B) [29] , and these types of channels are activated by membrane stretch [29] and externally applied ATP [30] . Various hormones, including hepatocyte growth factor [31] , vasopressin [32] , insulin [33] , and norepinephrine [10] , have been reported to activate Ca 2+ -permeable channels. In addition, hepatocytes possess Ca 2+ release-activated Ca 2+ channels [4,34,35] .…”

Section: +mentioning

confidence: 99%

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Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes

et al. 2008

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Aim:Hydrogen peroxide (H 2 O 2 ) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca 2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes. Methods: Hepatocytes were extracted from rats. Intracellular Ca 2+ concentrations ([Ca 2+ ] i ), inner mitochondrial membrane potentials and NAD(P)H levels were measured using fluorescence imaging. Phospholipase C (PLC) activity was detected using exogenous PIP 2 . ATP concentrations were measured using the luciferin-luciferase method. Patch-clamp recordings were performed to evaluate membrane currents.

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Section: +mentioning

confidence: 99%

“…In fact, excess Ca 2+ in the cell causes cellular damage by activating Ca 2+ -dependent proteases [10] , although cellular Ca 2+ overload is unlikely to be the sole mechanism mediating cell death [11] . Various mechanisms by which oxygen radicals cause an elevation of [Ca 2+ ] i have been described in different types of cells.…”

Section: Introductionmentioning

confidence: 99%