Evidence for influenza B virus lineage shifts and reassortants circulating in Thailand in 2014–2016

Tewawong, Nipaporn; Suntronwong, Nungruthai; Korkong, Sumeth; Theamboonlers, Apiradee; Vongpunsawad, Sompong; Poovorawan, Yong

doi:10.1016/j.meegid.2016.11.010

Cited by 17 publications

(16 citation statements)

References 24 publications

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“…Unlike influenza A, only a very small percentage of influenza B cases were characterized. It is usually very challenging to make reliable predictions on which lineage (Victoria or Yamagata) will dominate each influenza season, and the two lineages also differ in terms of their demographic characteristics. A better knowledge of the patterns of influenza B strain circulation may be helpful to estimate the effectiveness of vaccination campaigns and optimize influenza prevention interventions.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of seasonal influenza in the Middle East and North Africa regions, 2010‐2016: Circulating influenza A and B viruses and spatial timing of epidemics

Caini

Séblain

Cıblak

et al. 2018

Influenza Resp Viruses

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BackgroundThere is a limited knowledge regarding the epidemiology of influenza in Middle East and North Africa.ObjectivesWe described the patterns of influenza circulation and the timing of seasonal epidemics in countries of Middle East and North Africa.MethodsWe used virological surveillance data for 2010‐2016 from the WHO FluNet database. In each country, we calculated the median proportion of cases that were caused by each virus type and subtype; determined the timing and amplitude of the primary and secondary peaks; and used linear regression models to test for spatial trends in the timing of epidemics.ResultsWe included 70 532 influenza cases from seventeen countries. Influenza A and B accounted for a median 76.5% and 23.5% of cases in a season and were the dominant type in 86.8% and 13.2% of seasons. The proportion of influenza A cases that were subtyped was 85.9%, while only 4.4% of influenza B cases were characterized. For most countries, influenza seasonality was similar to the Northern Hemisphere, with a single large peak between January and March; exceptions were the countries in the Arabian Peninsula and Jordan, all of which showed clear secondary peaks, and some countries had an earlier primary peak (in November‐December in Bahrain and Qatar). The direction of the timing of influenza activity was east to west and south to north in 2012‐2013 and 2015‐2016, and west to east in 2014‐2015.ConclusionsThe epidemiology of influenza is generally uniform in countries of Middle East and North Africa, with influenza B playing an important role in the seasonal disease burden.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of seasonal influenza in the Middle East and North Africa regions, 2010‐2016: Circulating influenza A and B viruses and spatial timing of epidemics

Caini

Séblain

Cıblak

et al. 2018

Influenza Resp Viruses

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“…This is not surprising since multiple genotypes of RSV-A and RSV-B are known to co-circulate in a single season and emerging genotypes may replace previously predominant ones in subsequent years ( Pretorius et al, 2013 ). It is hypothesized that the periodic shifts in the predominant RSV subgroup are driven by the dynamics of population immunity and subgroup-specific herd immunity ( Botosso et al, 2009 ), whichis analogous to periodic lineage shifts of the influenza B virus over time ( Tewawong et al, 2017 ). Although co-infections by both RSV-A and RSV-B have previously been described in multiple regions ( Esposito et al, 2015 ; Parveen et al, 2006 ; Kouni et al, 2013 ), it was relatively rare in our study.…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus genotypes NA1, ON1, and BA9 are prevalent in Thailand, 2012–2015

Thongpan

Mauleekoonphairoj

Vichiwattana

et al. 2017

PeerJ

Self Cite

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Respiratory syncytial virus (RSV) causes acute lower respiratory tract infection in infants and young children worldwide. To investigate the RSV burden in Thailand over four consecutive years (January 2012 to December 2015), we screened 3,306 samples obtained from children ≤5 years old with acute respiratory tract infection using semi-nested reverse-transcription polymerase chain reaction (RT-PCR). In all, 8.4% (277/3,306) of the specimens tested positive for RSV, most of which appeared in the rainy months of July to November. We then genotyped RSV by sequencing the G glycoprotein gene and performed phylogenetic analysis to determine the RSV antigenic subgroup. The majority (57.4%, 159/277) of the RSV belonged to subgroup A (RSV-A), of which NA1 genotype was the most common in 2012 while ON1 genotype became prevalent the following year. Among samples tested positive for RSV-B subgroup B (RSV-B) (42.6%, 118/277), most were genotype BA9 (92.6%, 87/94) with some BA10 and BA-C. Predicted amino acid sequence from the partial G region showed highly conserved N-linked glycosylation site at residue N237 among all RSV-A ON1 strains (68/68), and at residues N296 (86/87) and N310 (87/87) among RSV-B BA9 strains. Positive selection of key residues combined with notable sequence variations on the G gene contributed to the continued circulation of this rapidly evolving virus.

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“…Therefore, the vaccine that was against influenza B was protective against only 24% of the influenza viruses in our participants. Notably, similar surveillance analyses of circulating influenza B virus during 2016 in other regions, including Thailand [ 26 ], showed that the Yamagata strains were predominant, thus confirming the presence of locoregional variations in influenza B virus infections.…”

Section: Discussionmentioning

confidence: 63%

Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016

Feng

Chen

Guan

et al. 2018

Virol J

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BackgroundFew studies have analyzed influenza B virus lineages based on hemagglutinin A (HA) gene sequences in southern China. The present study analyzed the HA gene and the lineages of influenza B virus isolates from Guangzhou during 2016, and compared our results with the WHO-recommended vaccine strain.MethodsNinety patients with influenza B were recruited from the First Hospital of Guangzhou Medical University. Throat swab specimens of 72 patients had high viral loads. Among these 72 isolates, the HA1 domain of the HA gene in 43 randomly selected isolates was sequenced using reverse transcription-polymerase chain reaction (RT-PCR), and analyzed using MEGA 5.05.ResultsEight of the 90 patients (8.9%) also had influenza A virus infections. Analysis of the 43 influenza B virus isolates indicated that 34 (79.1%) were from the Victoria lineage and 9 (20.9%) were from the Yamagata lineage. A comparison isolates in our Victoria lineage with the B/Brisbane/60/2008 strain indicated 12 mutation sites in the HA1 domain, 4 of which (I132V, N144D, C196S, and E198D) were in antigenic epitopes. A comparison of isolates in our Yamagata lineage with the B/Phuket/3073/2013 stain indicated 5 mutation sites in the HA1 domain, none of which was in an antigenic epitope. None of the isolates had a mutation in regions of the neuraminidase gene (NA) that are known to confer resistance to NA inhibitors.ConclusionIn Guangzhou during 2016, most influenza B virus isolates were from the Victoria lineage, in contrast to the vaccine strain recommended by the WHO for this period.Electronic supplementary materialThe online version of this article (10.1186/s12985-018-1085-5) contains supplementary material, which is available to authorized users.

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Evidence for influenza B virus lineage shifts and reassortants circulating in Thailand in 2014–2016

Cited by 17 publications

References 24 publications

Epidemiology of seasonal influenza in the Middle East and North Africa regions, 2010‐2016: Circulating influenza A and B viruses and spatial timing of epidemics

Epidemiology of seasonal influenza in the Middle East and North Africa regions, 2010‐2016: Circulating influenza A and B viruses and spatial timing of epidemics

Respiratory syncytial virus genotypes NA1, ON1, and BA9 are prevalent in Thailand, 2012–2015

Analysis of influenza B virus lineages and the HA1 domain of its hemagglutinin gene in Guangzhou, southern China, during 2016

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