Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents With Major Depressive Disorder

Croarkin, Paul E.; Nakonezny, Paul A.; Husain, Mustafa M.; Melton, Tabatha; Buyukdura, Jeylan S.; Kennard, Betsy D.; Emslie, Graham J.; Kozel, F. Andrew; Daskalakis, Zafiris J.

doi:10.1001/2013.jamapsychiatry.24

Cited by 56 publications

(59 citation statements)

References 69 publications

(73 reference statements)

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“…Danglot et al [22] constructed mutant mice lacking neuronal SNARE vesicles (TI-VAMP/VAMP7) to characterize forebrain neuronal synaptic release, and they found that the number of neurons was greatly reduced. Extremely high contents of glutamate have also been found in depressive patients, and clinical studies have indicated that depressive disorder is associated with increased glutamatergic activity [6].…”

Section: Discussionmentioning

confidence: 99%

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Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats

Zhao

Fu²,

et al. 2016

Journal of Acupuncture and Meridian Studies

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This study aims to investigate the molecular mechanisms of acupuncture in the remission of depression. A depressive disorder model was induced by exposing Sprague-Dawley rats to chronic unpredictable stress. The rats were divided into five groups: healthy (blank group) and stressed rats (model group), and stressed rats treated with acupuncture (acupuncture group), riluzole (riluzole group), acupuncture combined with botulinum toxin A (BTX-A) injection (acupuncture+BTX-A group) or riluzole combined with BTX-A injection (riluzole+BTX-A group). Behavioral analysis showed significant differences in sucrose consumption, weight, and horizontal or vertical movements between the model and both the riluzole and acupuncture groups. No obvious differences between the riluzole+BTX-A and acupuncture+BTX-A groups were found. Moreover, no significance differences in glutamate content in the hippocampus were found among the riluzole+BTX-A, acupuncture+BTX-A and model groups (p>0.05). Western blots and reverse transcription polymerase chain reactions were employed to detect protein and mRNA expressions of VGLUT2, SNAP25, VAMP1, VAMP2, VAMP7, and syntaxin1; no obvious differences among the riluzole+BTX-A, acupuncture+BTX-A and model groups were found. These data suggest that soluble N-ethylmaleimide-sensitive factor attachment receptor proteins are involved in the remission of depression in rats treated with acupuncture.

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Section: Discussionmentioning

confidence: 99%

“…Extremely high levels of glutamate have been found in depressive patients, and clinical studies have indicated that depressive disorders are associated with increased glutamatergic activity [6]. Glutamatergic neurotransmission occurs predominantly within the confines of a tripartite synapse.…”

Section: Introductionmentioning

confidence: 99%

Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats

Zhao

Fu²,

et al. 2016

Journal of Acupuncture and Meridian Studies

View full text Add to dashboard Cite

show abstract

“…Glutamate is also responsible for the maladaptive changes seen in the structure and function of various excitatory circuitries. Clinical evidence suggests that glutamatergic transmission is abnormal in depressed patients [15,29]. Stressors increase glutamate levels and affect the structure and morphology of the rodent brain [10].…”

Section: Discussionmentioning

confidence: 99%

“…Memantine, though an NMDA antagonist, decreases the glutamate levels and its transmission as well [14]. An increase in glutamate levels has been associated with depression [12,15]. Treatment with selective serotonin re-uptake inhibitors or monoamine oxidase inhibitors modulates the serotonergic transmission.…”

Section: Introductionmentioning

confidence: 99%

Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression

Abraham

Nirogi

Shinde

2014

Pharmacological Reports

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“…Actually, glutamate and especially elevated glutamate levels are also discussed to provoke a variety of psychiatric disorders like autism [14], schizophrenia, especially NSS [15] and depression [16], whereas in ADHD and manic patients elevated glutamine levels were found [17,18]. The reason for this is still unknown.…”

Section: Dear Sirmentioning

confidence: 99%

Is the vigilance regulation model of affective disorders and ADHD also appropriate for other psychiatric disorders (schizophrenia, autism) and is it associated with glutamate?

Niederhofer

2015

Medical Hypotheses

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Evidence for Increased Glutamatergic Cortical Facilitation in Children and Adolescents With Major Depressive Disorder

Cited by 56 publications

References 69 publications

Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats

Soluble N-ethylmaleimide-sensitive Factor Attachment Receptor (SNARE) Protein Involved in the Remission of Depression by Acupuncture in Rats

Role of glutamate and advantages of combining memantine with a 5HT6 ligand in a model of depression

Is the vigilance regulation model of affective disorders and ADHD also appropriate for other psychiatric disorders (schizophrenia, autism) and is it associated with glutamate?

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