Evidence for impaired skeletal load adaptation among Canadian women with type 2 diabetes mellitus: Insight into the BMD and bone fragility paradox

Hamilton, Celeste J.; Jamal, Sophie A.; Beck, Thomas; A, Khaled; Adachi, Jonathan D.; Brown, Jacques P.; Davison, K. Shawn

doi:10.1016/j.metabol.2013.05.004

Cited by 23 publications

(9 citation statements)

References 21 publications

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“…Regarding the lack of significant alterations in the executive function, maximal walking speed, and transfer capacity observed in T2DM after the 6-month MCEP, some investigations support our findings and demonstrate that T2DM patients present an impaired adaptability to physical stress (i.e., skeletal geometry) [ 39 ]. In addition, evidence demonstrates that T2DM patients present marked alterations in the cellular and physiological functioning of different tissues (e.g., brain, skeletal muscle) with a key role in the adaptive response to physical exercise [ 14 – 19 ].…”

Section: Discussionsupporting

confidence: 71%

Multicomponent Exercise Improves Hemodynamic Parameters and Mobility, but Not Maximal Walking Speed, Transfer Capacity, and Executive Function of Older Type II Diabetic Patients

Coelho-Júnior

Sanches

Doro

et al. 2018

BioMed Research International

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The present study aimed to investigate the effects of a 6-month multicomponent exercise program (MCEP) on functional, cognitive, and hemodynamic parameters of older Type 2 diabetes mellitus (T2DM) patients. Moreover, additional analyses were performed to evaluate if T2DM patients present impaired adaptability in response to physical exercise when compared to nondiabetic volunteers. A total of 72 T2DM patients and 72 age-matched healthy volunteers (CG) were recruited and submitted to functional, cognitive, and hemodynamic evaluations before and after six months of a MCEP. The program of exercise was performed twice a week at moderate intensity. Results indicate T2DM and nondiabetic patients present an increase in mobility (i.e., usual walking speed) after the MCEP. However, improvements in maximal walking speed, transfer capacity, and executive function were only observed in the CG. On the other hand, only T2DM group reveals a marked decline in blood pressure. In conclusion, data of the current study indicate that a 6-month MCEP improves mobility and reduce blood pressure in T2DM patients. However, maximal walking speed, transfer capacity, and executive function were only improved in CG, indicating that T2DM may present impaired adaptability in response to physical stimulus.

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Section: Discussionsupporting

confidence: 71%

Multicomponent Exercise Improves Hemodynamic Parameters and Mobility, but Not Maximal Walking Speed, Transfer Capacity, and Executive Function of Older Type II Diabetic Patients

Coelho-Júnior

Sanches

Doro

et al. 2018

BioMed Research International

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“…Also perimenopausal women with T2DM, despite the higher areal BMD of the femoral neck, had lower strength indices for compression and bending, which in turn inversely correlated with the homeostasis model-assessed insulin resistance [33]. Accordingly, women with diabetes have higher mechanical stress (evaluated by an engineering beam analysis, incorporating dimension and geometry obtained by hip structural analysis) despite higher femoral neck BMD [34]. This reflects weaker femoral geometry for a given load, and in turn suggests that bone fragility derives from an impaired adaptive response of the skeleton to load [34].…”

Section: Bone Structure/strength/turnover and Qualitymentioning

confidence: 98%

“…Accordingly, women with diabetes have higher mechanical stress (evaluated by an engineering beam analysis, incorporating dimension and geometry obtained by hip structural analysis) despite higher femoral neck BMD [34]. This reflects weaker femoral geometry for a given load, and in turn suggests that bone fragility derives from an impaired adaptive response of the skeleton to load [34]. The defective mechanical competence has been also related to poor metabolic control of diabetes.…”

Section: Bone Structure/strength/turnover and Qualitymentioning

confidence: 99%

Bone damage in type 2 diabetes mellitus

Carnevale

Romagnoli

D’Erasmo

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

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“…Moreover, non-enzymatic glycation (NEG), which consists of spontaneous reactions between extra-cellular sugars and free amino groups of several matrix proteins including collagen type I, leads to formation of molecular crosslinks which are known as advanced glycation end-products (AGEs). High concentrations of AGEs are known to increase bone fragility [38]. …”

Section: Discussionmentioning

confidence: 99%

Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

Neglia¹,

Argentiero²,

Chitano³

et al. 2016

IJERPH

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Objectives:We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods: We found 4909 postmenopausal subjects within ≥10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors. Results: Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m 2 . Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI (p < 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05-1.83) and 1.46 (CI: 1.20-1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI. Conclusions: Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis.

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Evidence for impaired skeletal load adaptation among Canadian women with type 2 diabetes mellitus: Insight into the BMD and bone fragility paradox

Cited by 23 publications

References 21 publications

Multicomponent Exercise Improves Hemodynamic Parameters and Mobility, but Not Maximal Walking Speed, Transfer Capacity, and Executive Function of Older Type II Diabetic Patients

Multicomponent Exercise Improves Hemodynamic Parameters and Mobility, but Not Maximal Walking Speed, Transfer Capacity, and Executive Function of Older Type II Diabetic Patients

Bone damage in type 2 diabetes mellitus

Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

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