Evidence for eosinophil degranulation in the pathogenesis of herpes gestationis

Scheman, A. J.

doi:10.1001/archderm.125.8.1079

Cited by 10 publications

(3 citation statements)

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“…There, these cells are activated and subsequently degranulate. 27 The degranulation products, among them proteases, are presumably responsible for the physical detachment of dermis and epidermis, yielding skin blisters and erosions. 28,29 A C C E P T E D M A N U S C R I P T…”

Section: Pathogenesismentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

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Section: Pathogenesismentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

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“…El anticuerpo estimula el complemento por la vía clásica (13,14), con la consiguiente quimiotaxis por eosinófilos y su degranulación (15), la que disolverá la unión entre epidermis y dermis, resultando en la liberación de mediadores químicos de la inflamación, los que serán responsables de la sintomatología -prurito-.…”

Section: Patogeniaunclassified

Herpes Gestationis

C.²,

T.³

et al. 2002

Rev. chil. obstet. ginecol.

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RESUMENHerpes gestationis es una rara enfermedad autoinmune que se presenta en mujeres embarazadas, compromete principalmente la piel y puede manifestarse como lesiones bulosas intensamente pruriginosas que, en ocasiones, son de difícil diagnóstico.Nosotros reportamos dos casos clínicos simultáneos que se presentaron en nuestro Servicio en marzo del año 2002, hecho que no deja de sorprender dado lo infrecuente y poco común de esta patología. PALABRAS CLAVES: Herpes gestationis, penfigoide gestacional, dermatosis del embarazo SUMMARYHerpes gestationis is an uncommon autoimmune disease seen in pregnant women. The condition involves mainly the skin, and results in bulous lesions with intense pruritus, which can sometimes be very difficult to deal with.We report 2 clinical cases which presented simultaneously at our Service, a surprising fact indeed, if we take into consideration the uncommon and peculiar character of this disease. KEY WORDS: Herpes gestationis, pemphigoid gestationis, autoimmune dermatosis of pregnancyTrabajos Originales *Trabajo leído en la sesión del 16 de julio de 2002 de la Sociedad Chilena de Obstetricia y Ginecología. INTRODUCCIONDurante el embarazo, ocurren numerosos cambios inmunológicos, metabólicos, endocrinos y vasculares los que harán susceptible a la mujer embarazada a cambios en la piel y sus anexos, sean estos fisiológicos o patológicos (1). Por esto, es importante reconocerlos, para clasificarlos correctamente y tratarlos cuando sea necesario.Clasificaremos las dermatosis del embarazo en las siguientes tres categorías (2):I. Cambios fisiológicos de la piel en el embarazo: cambios pigmentarios (melasma), alteraciones en el pelo, uñas y tejido conectivo (estrías).II. Dermatosis y tumores cutáneos afectados por el embarazo: a) Inflamatorios: dermatitis atópica, psoriasis, acné vulgaris, etc.

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“…Eosinophil granule protein deposition has been demonstrated not only in fully developed blisters, but also at the earliest stages of blister development and urticarial lesions of BP ( 73 , 92 ). Eosinophil degranulation has also been observed in pemphigoid gestationis, a gestational variant of BP, whereby MBP is deposited extracellularly in the dermis ( 93 ).…”

Section: Introduction To Eosinophilsmentioning

confidence: 99%

The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease

et al. 2018

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Bullous pemphigoid (BP) is an autoimmune blistering disease which carries a significant mortality and morbidity. While historically BP has been characterized as an IgG driven disease mediated by anti-BP180 and BP230 IgG autoantibodies, developments in recent years have further elucidated the role of eosinophils and IgE autoantibodies. In fact, eosinophil infiltration and eosinophilic spongiosis are prominent features in BP. Several observations support a pathogenic role of eosinophils in BP: IL-5, eotaxin, and eosinophil-colony stimulating factor are present in blister fluid; eosinophils line the dermo-epidermal junction (DEJ) in the presence of BP serum, metalloprotease-9 is released by eosinophils at the site of blisters; eosinophil degranulation proteins are found on the affected basement membrane zone as well as in serum corresponding with clinical disease; eosinophil extracellular DNA traps directed against the basement membrane zone are present, IL-5 activated eosinophils cause separation of the DEJ in the presence of BP serum; and eosinophils are the necessary cell required to drive anti-BP180 IgE mediated skin blistering. Still, it is likely that eosinophils contribute to the pathogenesis of BP in numerous other ways that have yet to be explored based on the known biology of eosinophils. We herein will review the role of eosinophils in BP and provide a framework for understanding eosinophil pathogenic mechanisms in mucocutaneous disease.

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Evidence for eosinophil degranulation in the pathogenesis of herpes gestationis

Cited by 10 publications

References 0 publications

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Herpes Gestationis

The Role of Eosinophils in Bullous Pemphigoid: A Developing Model of Eosinophil Pathogenicity in Mucocutaneous Disease

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