Evidence for Early Vulnerability of the Medial and Inferior Aspects of the Temporal Lobe in an 82-Year-Old Patient With Preclinical Signs of Dementia

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

“…These authors found amyloid de posits in the parahippocampal and the superior temporal gyri of all of their cases, whereas the hippocampus was frequently spared. These observations in centenarian brains parallel several earlier reports demonstrating the preferential development of this type of lesions in the neo cortex of younger demented patients [13,14,16,22,[42][43][44][45], Delaere et al [24] and Giannakopoulos et al [25] did not find any significant difference between the SP counts in demented and ND centenarians. Conversely, in the present series there was a highly significant difference between the SDAT and control cases, in all of the regions studied.…”

“…Finally, the demented cases from the psychiatric hospital present ed with significantly longer duration of illness than those from the geriatric hospital (2.9 ± 0.4 vs. 1.2 ± 0.3 years old; p<0.05). The results of the present study confirm previous reports on the particular features of the degenerative pro cess in oldest-old people [25][26][27], Moreover, the study of centenarians with SDAT shows that the neuropathological profile of this group may differ significantly from that observed in younger demented patients [13,14]. The number of neuroanatomical analyses of patients older than 95 years is still limited.…”

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

“…These authors found amyloid de posits in the parahippocampal and the superior temporal gyri of all of their cases, whereas the hippocampus was frequently spared. These observations in centenarian brains parallel several earlier reports demonstrating the preferential development of this type of lesions in the neo cortex of younger demented patients [13,14,16,22,[42][43][44][45], Delaere et al [24] and Giannakopoulos et al [25] did not find any significant difference between the SP counts in demented and ND centenarians. Conversely, in the present series there was a highly significant difference between the SDAT and control cases, in all of the regions studied.…”

“…Finally, the demented cases from the psychiatric hospital present ed with significantly longer duration of illness than those from the geriatric hospital (2.9 ± 0.4 vs. 1.2 ± 0.3 years old; p<0.05). The results of the present study confirm previous reports on the particular features of the degenerative pro cess in oldest-old people [25][26][27], Moreover, the study of centenarians with SDAT shows that the neuropathological profile of this group may differ significantly from that observed in younger demented patients [13,14]. The number of neuroanatomical analyses of patients older than 95 years is still limited.…”

Brain Aging in the Oldest-Old

“…In agreement with previous observations in centenarian brains [44], even cases with moderate dementia display only mild NFT formation in the entorhinal cortex with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than hippocampal regions [38, 69–71]. …”

Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?

“…In agreement with our previous observations in centenarian brains [34], even cases with moderate dementia display only mild NFT formation in this area with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than other hippocampal regions [30,41,49,50]. Our cases also displayed significantly lower total amyloid volume in the areas studied compared to that reported in younger series [47].…”

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

“…These authors found amyloid de posits in the parahippocampal and the superior temporal gyri of all of their cases, whereas the hippocampus was frequently spared. These observations in centenarian brains parallel several earlier reports demonstrating the preferential development of this type of lesions in the neo cortex of younger demented patients [13,14,16,22,[42][43][44][45], Delaere et al [24] and Giannakopoulos et al [25] did not find any significant difference between the SP counts in demented and ND centenarians. Conversely, in the present series there was a highly significant difference between the SDAT and control cases, in all of the regions studied.…”

“…Finally, the demented cases from the psychiatric hospital present ed with significantly longer duration of illness than those from the geriatric hospital (2.9 ± 0.4 vs. 1.2 ± 0.3 years old; p<0.05). The results of the present study confirm previous reports on the particular features of the degenerative pro cess in oldest-old people [25][26][27], Moreover, the study of centenarians with SDAT shows that the neuropathological profile of this group may differ significantly from that observed in younger demented patients [13,14]. The number of neuroanatomical analyses of patients older than 95 years is still limited.…”

Brain Aging in the Oldest-Old

“…In agreement with previous observations in centenarian brains [44], even cases with moderate dementia display only mild NFT formation in the entorhinal cortex with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than hippocampal regions [38, 69–71]. …”

Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?

“…In agreement with our previous observations in centenarian brains [34], even cases with moderate dementia display only mild NFT formation in this area with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than other hippocampal regions [30,41,49,50]. Our cases also displayed significantly lower total amyloid volume in the areas studied compared to that reported in younger series [47].…”

Dementia in the Oldest-Old:Quantitative Analysis of 12 Cases from a Psychiatric Hospital

“…These authors found amyloid de posits in the parahippocampal and the superior temporal gyri of all of their cases, whereas the hippocampus was frequently spared. These observations in centenarian brains parallel several earlier reports demonstrating the preferential development of this type of lesions in the neo cortex of younger demented patients [13,14,16,22,[42][43][44][45], Delaere et al [24] and Giannakopoulos et al [25] did not find any significant difference between the SP counts in demented and ND centenarians. Conversely, in the present series there was a highly significant difference between the SDAT and control cases, in all of the regions studied.…”

“…Finally, the demented cases from the psychiatric hospital present ed with significantly longer duration of illness than those from the geriatric hospital (2.9 ± 0.4 vs. 1.2 ± 0.3 years old; p<0.05). The results of the present study confirm previous reports on the particular features of the degenerative pro cess in oldest-old people [25][26][27], Moreover, the study of centenarians with SDAT shows that the neuropathological profile of this group may differ significantly from that observed in younger demented patients [13,14]. The number of neuroanatomical analyses of patients older than 95 years is still limited.…”

Brain Aging in the Oldest-Old

“…In agreement with previous observations in centenarian brains [44], even cases with moderate dementia display only mild NFT formation in the entorhinal cortex with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than hippocampal regions [38, 69–71]. …”

Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?

“…In agreement with our previous observations in centenarian brains [34], even cases with moderate dementia display only mild NFT formation in this area with more than 80% of preserved neurons. This contrasts with the results of several previous studies in younger samples which demonstrated that the entorhinal cortex is more severely affected and involved earlier in the degenerative process than other hippocampal regions [30,41,49,50]. Our cases also displayed significantly lower total amyloid volume in the areas studied compared to that reported in younger series [47].…”