Evidence for an enterohepatic circulation of ochratoxin A in mice

Bioaccessibility of ochratoxin A from red wine in anin vitro dynamic gastrointestinal model

“…Our results and the results of studies mentioned above are in line with the in vivo data reported by Galtier (1978) and Roth et al (1988), authors that attribute this behaviour to the acidic properties of OTA (Galtier, 1978;Kumagai and Aibara, 1982). However, Kabak et al (2009) reported much lower bioaccessibilities; only 22% was found for buckwheat (24.9 μg OTA/kg) and 29-32% for infant food (2-13.1 μg OTA/kg), in spiked foods.…”

Bioaccessibility of ochratoxin A from red wine in anin vitro dynamic gastrointestinal model

“…Our results and the results of studies mentioned above are in line with the in vivo data reported by Galtier (1978) and Roth et al (1988), authors that attribute this behaviour to the acidic properties of OTA (Galtier, 1978;Kumagai and Aibara, 1982). However, Kabak et al (2009) reported much lower bioaccessibilities; only 22% was found for buckwheat (24.9 μg OTA/kg) and 29-32% for infant food (2-13.1 μg OTA/kg), in spiked foods.…”

An Algoclay-Based Decontaminant Decreases Exposure to Aflatoxin B1, Ochratoxin A, and Deoxynivalenol in a Toxicokinetic Model, as well as Supports Intestinal Morphology, and Decreases Liver Oxidative Stress in Broiler Chickens Fed a Diet Naturally Contaminated with Deoxynivalenol

“…The appearance of a second peak of OTA in the plasma of broiler chickens at 8 h p.a. corresponds to previously described kinetics [25,27], and it is associated with the enterohepatic recirculation of OTA following its biliary excretion and reabsorption in the intestine [28]. The administration of the algoclay-based decontaminant along with the mycotoxins reduced the exposure to the three mycotoxins tested.…”

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

“…This could be explained by the circumstance that PHE was found to increase the absorption of OTA from the stomach and intestine as well as the gastrointestinal transit of OTA resulting in fourfold up to eightfold higher levels of OTA in serum, as has been reported in some experiments with mice [17]. On the other hand the main mechanisms of OTA-toxicity in our case may not involve the inhibition of phenylalanine metabolizing enzymes.…”

Bioaccessibility of ochratoxin A from red wine in anin vitro dynamic gastrointestinal model

“…Our results and the results of studies mentioned above are in line with the in vivo data reported by Galtier (1978) and Roth et al (1988), authors that attribute this behaviour to the acidic properties of OTA (Galtier, 1978;Kumagai and Aibara, 1982). However, Kabak et al (2009) reported much lower bioaccessibilities; only 22% was found for buckwheat (24.9 μg OTA/kg) and 29-32% for infant food (2-13.1 μg OTA/kg), in spiked foods.…”

An Algoclay-Based Decontaminant Decreases Exposure to Aflatoxin B1, Ochratoxin A, and Deoxynivalenol in a Toxicokinetic Model, as well as Supports Intestinal Morphology, and Decreases Liver Oxidative Stress in Broiler Chickens Fed a Diet Naturally Contaminated with Deoxynivalenol

“…The appearance of a second peak of OTA in the plasma of broiler chickens at 8 h p.a. corresponds to previously described kinetics [25,27], and it is associated with the enterohepatic recirculation of OTA following its biliary excretion and reabsorption in the intestine [28]. The administration of the algoclay-based decontaminant along with the mycotoxins reduced the exposure to the three mycotoxins tested.…”

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

“…This could be explained by the circumstance that PHE was found to increase the absorption of OTA from the stomach and intestine as well as the gastrointestinal transit of OTA resulting in fourfold up to eightfold higher levels of OTA in serum, as has been reported in some experiments with mice [17]. On the other hand the main mechanisms of OTA-toxicity in our case may not involve the inhibition of phenylalanine metabolizing enzymes.…”

Bioaccessibility of ochratoxin A from red wine in anin vitro dynamic gastrointestinal model

“…Our results and the results of studies mentioned above are in line with the in vivo data reported by Galtier (1978) and Roth et al (1988), authors that attribute this behaviour to the acidic properties of OTA (Galtier, 1978;Kumagai and Aibara, 1982). However, Kabak et al (2009) reported much lower bioaccessibilities; only 22% was found for buckwheat (24.9 μg OTA/kg) and 29-32% for infant food (2-13.1 μg OTA/kg), in spiked foods.…”

An Algoclay-Based Decontaminant Decreases Exposure to Aflatoxin B1, Ochratoxin A, and Deoxynivalenol in a Toxicokinetic Model, as well as Supports Intestinal Morphology, and Decreases Liver Oxidative Stress in Broiler Chickens Fed a Diet Naturally Contaminated with Deoxynivalenol

“…The appearance of a second peak of OTA in the plasma of broiler chickens at 8 h p.a. corresponds to previously described kinetics [25,27], and it is associated with the enterohepatic recirculation of OTA following its biliary excretion and reabsorption in the intestine [28]. The administration of the algoclay-based decontaminant along with the mycotoxins reduced the exposure to the three mycotoxins tested.…”

Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks

“…This could be explained by the circumstance that PHE was found to increase the absorption of OTA from the stomach and intestine as well as the gastrointestinal transit of OTA resulting in fourfold up to eightfold higher levels of OTA in serum, as has been reported in some experiments with mice [17]. On the other hand the main mechanisms of OTA-toxicity in our case may not involve the inhibition of phenylalanine metabolizing enzymes.…”