Evidence for an association of human papillomavirus infection and colorectal cancer

The Aetiological Role of Human Papillomavirus in Colorectal Carcinoma: An Iranian Population- Based Case Control Study

“…Furthermore, we detected HPV-45 and HPV-31, which have not been previously reported in patients with colorectal carcinoma in Iran but have been recognized as high-risk types in malignant diseases (Yahyapour et al, 2013). In comparison with this study, Damin et al (2007), Chen et al (2012) and Burnett-Hartman et al (2013) found HPV-16 as the most frequently detected HPV type in patients with CRC. Therefore, this study supports the hypothesis that expresses the different frequency patterns of HPV infection according to geographical variations and ethnicity of the populations (Jung et al, 2004;Chansaenroj According to Table 3, analysis of medical data in infected patients with CRC in compare to non-infected patients with CRC explained a possible association between high-risk types of HPV infections and accession Gillison and shah (2003), Chen et al (2012), Hamid and Mustafa (2012), Ghasemian et al (2013), Zandberg et al (2013) in comparison with results from Motlagh et al (2007), Giuliani et al (2008) investigate the ability of HPV infection to induce advanced stages of cancer in different malignancies.…”

“…This is in keeping with al. (2011) and Burnett-Hartman et al (2013), but some incidence of colorectal carcinoma (Bodaghi et al, 2005;Damin et al, 2007;Motlagh et al, 2007;Chen et al, 2012). This diversity has been explained according to possibility of contamination in sample preparation and testing and different frequency of HPV infection between populations which may be affected of high-risk sexual behaviors (Bodaghi et al, 2005;Burnett-Hartman et al, 2008;Burnett-Hartman et al, 2011).…”

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

“…Some authors have demonstrated HPV DNA in 46/72 (64%) 35 and 23/55 (42%) 36 of colorectal carcinoma, suggesting a role for HPV infection, particularly HPV type 16, in colorectal carcinogenesis. However, both of these studies also reported the presence of HPV DNA in a large proportion of histologically normal mucosa adjacent to the colorectal carcinomas.…”

HPV in non-gynecological tumors

“…Die Debatte hält aber auch hier an, und so wurden in den Jahren 2001 und 2007 Detektionsraten von 84 bzw. 83% beschrieben [4,16].…”

“…Daneben fallen Unterschiede in der geografischen Verteilung der Studien auf. Während die negativen Ergebnisse in der Regel an zentraleuropäischen -Schweiz und Frankreich [6,18] -und amerikanischen Patientenkollektiven erhoben wurden [21], fanden sich die positiven Ergebnisse gehäuft in Asien, speziell Taiwan [16], Lateinamerika/Brasilien [4,5] oder auch der Türkei [2]. Insofern spielen regionale Unterschiede bezüglich der Inzidenz von HPV in der Normalbevölkerung eine nicht unwichtige Rolle bei der Interpretation der Ergebnisse wie auch der möglichen Assoziation mit der Tumorentstehung.…”