Evidence‐based (S3) guidelines for diagnostics and treatment of venous leg ulcers

Background: Venous leg ulcers (VLUs) are common throughout the world, which seriously affects the patient's work and life. Relevant researches suggested that sclerosing foam (SF) has potential benefits for VLUs. However, there is no consistent conclusion. The purpose of our study is to assess whether SF is effective and safe for VLUs. Methods: Relevant clinical randomized controlled trials will be obtained from a search of 8 databases (with no language restrictions) from their inception to May 2020: PubMed, the Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, and Chinese Biological Medicine. Data will be analyzed using RevMan 5.3 after literature screening and data extraction according to predefined inclusion and exclusion criteria. Cochrane Collaboration Risk of bias Tool will be applied in evaluating the quality of enrolled articles. The primary outcome is Closure of venous leg ulcers, ulcer healing rate, adverse events related to SF. The secondary outcomes include ulcer healing time, ulcer recurrence rate, pain. Risk ratio will be used for categorical data; mean differences will be used for measurement data. Where possible and appropriate, meta-analysis will be performed for each outcome. Results: To clarify whether Sclerosing foam can be safe and efficient on treating venous leg ulcers. Conclusion: Our review will provide useful information to judge whether Sclerosing Foam is an effective and safe intervention for patients with venous leg ulcers.

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“…The Diagnostic Criteria for VLUs: Refer to the Evidence-based (S3) guidelines for diagnostics and treatment of venous leg ulcers. [ 20 ]…”

Section: Methodsmentioning

confidence: 99%

The safety and efficacy of Sclerosing foam on treating venous leg ulcers

Fan

Yang

et al. 2020

Medicine

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“…Chronic venous insufficiency (CVI) is a disease with numerous symptoms, including skin changes resulting from circulation disturbances caused by venous valve failure, venous reflux, an insufficient venous return, post-thrombotic syndrome, and venous hypertension [ 1 , 2 , 3 , 4 , 5 ]. Initially, venous leg insufficiency is clinically manifested by telangiectasias, varicose veins or interstitial edema.…”

Section: Introductionmentioning

confidence: 99%

“…As the disease progresses, other symptoms such as hemosiderosis, lipodermatosclerosis, or stasis dermatitis on the legs can be observed [ 5 ]. Venous leg ulcer (VLU) is the most advanced form of this disease, often combined with searing pain, most often located on the inside surface of lower extremities between the ankle area and the mid-calf [ 1 , 5 ]. Moreover, untreated and long-lasting CVI can cause secondary lymphedema and the increased risk of cellulitis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The disease also has a significant impact on social life and mental health. About 30% of patients experience anxiety or depression [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…VLUs are the most widespread type of leg ulcers. Their prevalence is rated between 1.5% and 3% in the general population and about 75% of leg ulcers have venous etiology [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Venous Leg Ulcers: Advanced Therapies and New Technologies

2021

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The prevalence of venous leg ulcers (VLUs) differs between 1.5% and 3% in the general population. The challenge in treating VLUs is common recurrence. Moreover, VLUs can be resistant to healing, despite appropriate treatment. In these cases, advanced wound therapies should be considered. The number of new technologies, applied in VLUs treatment, has increased in the last years. These therapies include biophysical interventions such as ultrasound therapy, electrical stimulations, electromagnetic therapy, or phototherapy. Furthermore, stem cell therapies, biologic skin equivalents, platelet-rich plasma therapy, oxygen therapies, anti-TNF therapy, or negative pressure wound therapy are advanced venous ulcer therapeutic methods that may support the standard of care. Medical devices, such as a muscle pump activator, or intermittent pneumatic compression device, may be especially useful for specific subgroups of patients suffering from VLUs. Some of the above-mentioned technologies require broader evidence of clinical efficacy and are still considered experimental therapies in dermatology.

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Leg Ulcers

Läuchli,

Streit

2023

European Handbook of Dermatological Treatments

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Evidence‐based (S3) guidelines for diagnostics and treatment of venous leg ulcers

Cited by 45 publications

References 214 publications

The safety and efficacy of Sclerosing foam on treating venous leg ulcers

The safety and efficacy of Sclerosing foam on treating venous leg ulcers

Venous Leg Ulcers: Advanced Therapies and New Technologies

Leg Ulcers

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