Evaluation of tumor necrosis factor alpha serum level in obese and lean women with clomiphene citrate resistant polycystic ovary disease

Seyam, Emaduldin; Mohammed, Mo’men M.; Khalifa, Eissa; Ramadan, Ahmad Riad; Hefzy, Enas

doi:10.1016/j.mefs.2017.01.008

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Serum TNF-α is significantly elevated in patients with PCOS and is related to hyperandrogenemia and insulin resistance (9). A metaanalysis of 1,046 patients with PCOS and 914 controls (10) also confirmed that TNF-α was elevated in patients with (11). Similarly, the results of this study also showed that TNF-α is related to clomiphene resistance in PCOS and is the most effective discriminator of clomiphene resistance in PCOS patients.…”

Section: Discussionsupporting

confidence: 72%

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

Wang¹,

Teng²,

Wu³

et al. 2021

Ann Palliat Med

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Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. We aimed to investigate the correlations between proinflammatory cytokine levels and clomiphene resistance in patients with PCOS.Methods: Between January 2019 and January 2020, a total of 72 PCOS patients who attended our department were administered clomiphene 50-100 mg/day on days 5-9 of the menstrual cycle to induce ovulation. Patients were divided into a clomiphene-sensitive group (n=42) and a clomiphene-resistant group (n=30). The proinflammatory cytokines interleukin-23 (IL-23), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor α (TNF-α), angiopoietin-2, and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA). The receiver-operating characteristic curve was employed to determine the capability of various parameters to distinguish clomiphene resistance. The univariate logistic regression analysis was used to analyze the associations between pro-inflammatory cytokine levels and clomiphene resistance in PCOS.Results: Serum IL-23 levels showed no statistically significant difference between the clomiphene-sensitive and the clomiphene-resistant groups, whereas MCP-1, TNF-α, angiopoietin-2, and adiponectin levels were significantly different between the two groups (all P<0.05). Univariate logistic regression analysis indicated that elevated serum TNF-α [odds ratio (OR) =1.88, P<0.001], decreased angiopoietin-2 (OR =0.61, P=0.007), and adiponectin (OR =0.39, P=0.012) levels were significantly associated with clomiphene resistance. The sensitivity of TNF-α and angiopoietin-2 to distinguish clomiphene resistance in patients with PCOS was 100%. Moreover, the diagnostic efficiency of TNF-α and adiponectin in identifying clomiphene resistance was significantly higher than that of MCP-1 and angiopoietin-2 (all P<0.05).Conclusions: Abnormal TNF-α, angiopoietin-2, and adiponectin levels may be associated with clomiphene resistance in PCOS patients. The serum proinflammatory cytokines TNF-α and adiponectin are helpful discriminators of clomiphene resistance in PCOS patients.

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Section: Discussionsupporting

confidence: 72%

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

Wang¹,

Teng²,

Wu³

et al. 2021

Ann Palliat Med

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“…Peluso and Palmery [25] suggested that inflammation is a consequence rather than a cause of obesity. Additionally, TNF-α is positively correlated with BMI and this correlation could be considered an important factor in obesity pathogenesis [26]. Also, some authors have reported that the expression of TNF-α mRNA in the AT is positively correlated to the body fat, insulin and TG levels [27].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

et al. 2020

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Obesity is an alarming threat to health in Egypt. More than one in three Egyptians is obese, the highest rate in the world. We aimed to delineate the variability of inflammation and endothelial dysfunction markers among Egyptian females with different obesity classes. Out of 130 females, 70 were categorized into 3 obesity groups: Class I, BMI 30–34.9kg/m2; Class II, BMI 35–39.9 kg/m2 and Class III BMI ≥ 40kg/ m2, besides 60 control subjects. Anthropometric measurements were recorded and serum levels of tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin 6 (IL-6), IL-12, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular adhesion molecule 1(sVCAM-1) were assessed among participants. In all three classes of obesity, significant increase (P <0.05) in BMI, waist-hip ratio, fat mass and body fat mass % were noted. CRP and sVCAM-1 levels were increased among the 3 obesity groups. TNF-α levels were increased in class II and III obesity groups. IL-6 and IL-12 levels were elevated in class I and class III groups. While, ICAM-1 levels were increased in class III obesity group. Based on individuals’ BMI, serum levels of TNF-α, CRP, IL-6, IL-12, sVCAM-1 and sICAM-1 are differentially altered with the progression of obesity. We strongly support the hypothesis that, as the obesity rate is still mounting, a subclinical inflammatory reaction has a role in pathogenesis of obesity and emphasize the elevation of endothelial dysfunction in individuals with obesity.

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“…PCOS is also characterized by systemic low-grade inflammation [208,209]. Some studies show that PCOS patients had an elevated C-reactive protein [210] and inflammatory cytokines [211,212]. HMGB1 increases in adolescents with PCOS, and levels of HMGB1 can be decreased by the administration of myo-inositol and alpha-lipoic acid, both considered to be anti-inflammatory [213].…”

Section: Ovulationmentioning

confidence: 99%

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

Negishi

Shima

Takeshita

et al. 2020

Immunological Medicine

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In reproduction, inflammatory processes play important roles in the development of many pregnancy complications such as preterm labor/birth, recurrent pregnancy loss, recurrent implantation failure, and preeclampsia. Inflammation can be initiated by both microbial and non-microbial causes. Bacterial infection in the feto-maternal interface and uterus can provoke preterm labor/birth, miscarriage, and chronic endometritis. By contrast, inflammation without infection, or 'sterile inflammation,' can also lead to many kinds of complications, such as preterm labor/birth, miscarriage, or preeclampsia. Aberrant inflammation is facilitated by immune cells such as macrophages, dendritic cells, natural killer cells, and invariant natural killer T cells. In addition, cytokines, chemokines, and several kinds of inflammatory mediators are involved. On the other hand, appropriate inflammation is required for a successful offspring during the progression of the entire pregnancy. Herein, we discuss the relation between pregnancy and inflammation with immunological alterations. Understanding the role of inflammation in complications during pregnancy may establish new perspectives of the progress of normal pregnancy as well as treatments during pregnancy complications.

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Evaluation of tumor necrosis factor alpha serum level in obese and lean women with clomiphene citrate resistant polycystic ovary disease

Cited by 3 publications

References 35 publications

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

Relationship between proinflammatory cytokines and clomiphene resistance in patients with polycystic ovary syndrome

Inflammatory and endothelial dysfunction indices among Egyptian females with obesity classes I–III

Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation

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