Evaluation of tumor markers in patients with squamous cell carcinoma in the oral cavity

Kurokawa, Hideo; Tsuru, Shoji; Okada, Masaaki; Nakamura, Takashi; Kajiyama, Minoru

doi:10.1016/s0901-5027(05)80353-4

Cited by 43 publications

(29 citation statements)

References 16 publications

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“…Circulatory tumor markers for OSCC were investigated in various studies (12 -21) and showed relatively moderate sensitivity and specificity values with relation to diagnosis, prognosis predicting, or treatment monitoring. For example, Kurokawa et al analyzed circulatory carcinoembryonic antigen (CEA), SCC, immunosuppressive acidic protein, and Cyfra concentrations in OSCC patients and found sensitivity and accuracy values of 81% and 77.8%, respectively, and when they analyzed CEA, SCC, and immunosuppressive acidic protein, the values were 69% and 90.3%, respectively (22,23). Hoffmann et al (21) and Krimmel et al (20), who analyzed circulatory levels of SCC, CEA, CA19-9, and CA125, found correlation with the tumor burden for only the SCC antigen.…”

mentioning

confidence: 99%

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Nagler¹,

Bahar

Shpitzer

et al. 2006

Clinical Cancer Research

181

119

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Purpose: Oral squamous cell carcinoma (OSCC) is a common human malignancy. Circulatory epithelial tumor markers were previously investigated in the serum of OSCC patients but almost never in their saliva, in spite of the fact that there is a direct contact between the saliva and the oral cancer lesion. The purpose of the current study was to examine tumor markers in the saliva of OSCC patients. Experimental Design:We measured the concentrations of the six most studied epithelial serum circulatory tumor markers in the saliva of OSCC (tongue) patients. Results: Significant increases (of 400 %) in salivary concentrations of Cyfra 21-1, tissue polypeptide antigen, and CA125 were shown. Salivary concentrations of CA19-9, SCC, and carcinoembryonic antigen were increased without statistical significance. A concurrent analysis of the three significantly increased markers revealed sensitivity, specificity, and negative and positive predictive values of 71%, 75%, 71%, and 75%, respectively. Conclusions: The increase reported in salivary tumor markers may be used as a diagnostic tool, especially when a concurrent analysis for significantly increased markers is done. Salivary testing is noninvasive, making it an attractive, effective alternative to serum testing, and the possibility of developing home testing kits would further facilitate it as a diagnostic aid, enabling patients to monitor their own health at home and is important for those who live far from their treatment centers and especially for those at risk of developing OSCC.Oral squamous cell carcinoma (OSCC) is a common human malignancy, with an increasing incidence (especially in younger people) and a 5-year mortality rate of f50% (1 -4), which has not changed significantly in >50 years (5 -11). Its location and treatment in the mouth/face/neck result in a relatively high rate of related morbidity, as the treatment frequently results in a significant mutilation and compromised functions. OSCC includes both mobile (oral) and base of tongue cancer lesions. Most often, an oral cancer lesion is located at the lateral border of the tongue, whereas one located at the base of tongue is considered especially lethal. Clinically, it is important to note that the therapeutic modality currently offered to patients is based on traditional stage-predicting indices (based mostly on the tumor-nodemetastasis criteria) and on histologic grading. Unfortunately, these predictors are subjective and relatively unreliable, as often two tumors with identical staging and grading behave in totally different fashions, and although one responds to therapy, the other is lethal. Accordingly, there has been an ever-growing effort dedicated to the basic research of oral cancer, focusing on the identification of biological indicators for the diagnosis of its biological nature and aggressiveness. Circulatory tumor markers for OSCC were investigated in various studies (12 -21) and showed relatively moderate sensitivity and specificity values with relation to diagnosis, prognosis predicti...

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confidence: 99%

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Nagler¹,

Bahar

Shpitzer

et al. 2006

Clinical Cancer Research

181

119

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“…These serpins possess uncleaved signal sequences and are considered members of a branch of the serpin family called "Ov-serpins" because of their relatedness to the well-studied secreted chicken serpin ovalbumin (Remold-O'Donnell 1993). PAI-2 is found both extracellularly in a glycosylated form and intracellularly in a nonglycosylated form, and SCCA1 is secreted by squamous cell carcinomas (Wohlwend et al 1987;Ye et al 1988;von Heijne et al 1991;Kurokawa et al 1993). Little is known about the underlying molecular mechanism(s) that allow secretion of these serpins, but the hydrophobicity of the amino terminal domains of these proteins does determine their topology.…”

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confidence: 99%

Maspin Is an Intracellular Serpin That Partitions into Secretory Vesicles and Is Present at the Cell Surface

Pemberton¹,

Tipton²,

Pavloff³

et al. 1997

J Histochem Cytochem.

137

139

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SUMMARYThe tumor suppressor maspin (mammary serpin) was originally identified as a component of human mammary epithelial cells that is downregulated as mammary tumor cells progress from the benign to the invasive and metastatic states. Maspin inhibits cellular invasion, motility, and proliferation, but its mechanism of action is currently unknown. Because the cellular machinery responsible for these processes is cytoplasmic, we have reexamined the tissue distribution and subcellular localization of maspin. We find that maspin, or a maspin-like protein, is present in many human organs, in which it localizes to epithelia. In cultured human mammary myoepithelial cells, maspin is predominantly a soluble cytoplasmic protein that associates with secretory vesicles and is present at the cell surface. In vitro assays show that the vesicle association is due to the existence of an uncleaved facultative secretion signal that allows small amounts of maspin to partition into the endoplasmic reticulum. These results demonstrate that maspin is more widespread than previously believed. The subcellular localization studies indicate that soluble intracellular and vesicleassociated maspin probably play an important role in controlling the invasion, motility, and proliferation of cells expressing it, whereas extracellular maspin may also regulate these processes in adjacent cells.

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“…Many markers have been evaluated for OSCC, some of which were tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), surface antigen, 100 Da (S-100), carbohydrate antigen 19-9 (CA 19-9), CA 125, CA 15-3, squamous cell carcinoma antigen (SCCA), immunosuppressive acidic protein (IAP), alpha-foetoprotein (AFP) and ferritin (FER) (Zoller et al, 1990;Kurokawa et al, 1993;Kuo et al, 1999;Hofele et al, 2002). TPA, CEA, CA 19-9 and CA125 levels were analysed in a group of patients with laryngeal or oral cancer pre-and post-therapy (Kuo et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Only TPA and CEA levels decreased significantly after therapy but clinical use in the disease was described to be limited (Kuo et al, 1999). Another study analysed serum levels of CEA, SCCA, IAP, AFP, FER and CA 19-9 in patients with primary OSCC (Kurokawa et al, 1993). The positive rates were reported to be 34.5% for CEA, 41.4% for SCCA, 51.7% for IAP, 0% for AFP, 10.3% for FER and 6.9% for CA 19-9, and it was concluded that only a combination of the analysis of CEA, SCCA and IAP could be of some value in the diagnosis of OSCC (Kurokawa et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Another study analysed serum levels of CEA, SCCA, IAP, AFP, FER and CA 19-9 in patients with primary OSCC (Kurokawa et al, 1993). The positive rates were reported to be 34.5% for CEA, 41.4% for SCCA, 51.7% for IAP, 0% for AFP, 10.3% for FER and 6.9% for CA 19-9, and it was concluded that only a combination of the analysis of CEA, SCCA and IAP could be of some value in the diagnosis of OSCC (Kurokawa et al, 1993). Another study did show that the diagnostic value of the tumour markers CEA, Ca 19-9, Ca 125, Ca15-3 exhibited a poor sensitivity in the follow-up of squamous cell carcinoma of the head and neck (Zoller et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

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Follow-up of collagen crosslink excretion in patients with oral squamous cell carcinoma and analysis of tissue samples

et al. 2003

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The presence of an oral squamous cell carcinoma (OSCC) may be associated with increased urinary excretion of the markers of collagen degradation, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). We investigated the possibility of these markers predicting the presence of active disease. Patients from a current study on HP and LP were included as follows: Group 1a (OSCC with confirmed mandibular bony infiltration, n ¼ 12), group 1b (group 1a patients 46 months after successful treatment), group 2a (OSCC without evidence of mandibular bone infiltration, n ¼ 8), group 2b (group 2a patients 46 months after successful treatment), group 3a (recurrent OSCC, n ¼ 8), group 3b (group 3a patients 46 weeks later, symptoms unchanged) and group 4 (control group, n ¼ 74). Tissue samples from tumour tissue and adjacent healthy mucosa were additionally investigated for HP and LP concentrations (n ¼ 8). The decrease in the urinary concentrations of HP and LP was statistically significant between groups 1a and 1b (Po0.001 for HP and LP), but not between groups 2a and 2b (P ¼ 0.07 for HP and LP), while values in groups 1b and 2b were within the normal range. When comparing groups 3a and 3b, a significant increase was observed for LP (P ¼ 0.050), but not HP (P ¼ 0.208). In conclusion, successful treatment of OSCC with bony involvement may be associated with a reduction of urinary HP and LP, whereas ongoing disease may result in an increase of LP. HP and LP may both be useful markers of tumour progression in patients with OSCC. British Journal of Cancer (2003) Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible crosslinks of mature collagen, which are formed by a sequence of post-translational modifications. HP is a derivative of three residues of hydroxylysine, and is present in virtually all mature tissues (tendon, vessel wall, cartilage, dentine and bone). LP is a derivative of two residues of hydroxylysine and one residue of lysine, and is found primarily in dentine and bone (Body and Delmas, 1992;Eyre, 1992;Miyamoto et al, 1994;Acil et al, 1996Acil et al, , 2002aPapatheofanis, 1997;Tamada et al, 2001;Jepsen et al, 2003; Springer et al, 2003a, b).It has been suggested that the detection of LP in the serum or urine may be a helpful marker in establishing and possibly quantifying bone matrix resorption (Body and Delmas, 1992;Miyamoto et al, 1994;Vinholes et al, 1996;Papatheofanis, 1997;Tamada et al, 2001;Springer et al, 2003a). In a previous study, we were able to assess the range and upper limit (HP max and LP max ) of normal values. We were able to show that the measurement of LP in the urine was able to separate a group of patients with oral squamous cell carcinoma (OSCC) with bone infiltration from patients with OSCC without bone infiltration with a sensitivity of 100% and a specificity of 100% (Springer et al, 2003a). In that paper, we suggested that when the level of LP exceeds LP max in a patient with a confirmed OSCC, bony invasion by the malignant process is highly likely and further inve...

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Evaluation of tumor markers in patients with squamous cell carcinoma in the oral cavity

Cited by 43 publications

References 16 publications

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Maspin Is an Intracellular Serpin That Partitions into Secretory Vesicles and Is Present at the Cell Surface

Follow-up of collagen crosslink excretion in patients with oral squamous cell carcinoma and analysis of tissue samples

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