Evaluation of the validity of risk malignancy index in clinically diagnosed ovarian masses and to compare it with the validity of individual constituent parameter of risk malignancy index

Yelikar, Kanan; Deshpande, Sonali; Nanaware, Sandip Sopan; Pagare, Sanjaykumar

doi:10.18203/2320-1770.ijrcog20160391

Cited by 4 publications

(4 citation statements)

References 11 publications

(9 reference statements)

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“…22 Similar finding was seen in study in other studies. 23,24 Likewise, in this study, RMI 5 is better in comparison to its individual parameters for detection of malignancy. The diagnostic accuracy of RMI 5 is 94.44 which is similar to that of Doppler score 2 (94.7) while it is much higher than that of the rest of the parameters (CA-125: 72.2, Ultrasound score: 87.…”

Section: Resultsmentioning

confidence: 48%

Modified Risk of Malignancy Index (RMI 5) in ovarian tumor

Joshi

Baral

2021

Nepal J Obstet Gynaecol

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Aims: To evaluate the role of modified RMI (RMI 5) in pre-operative evaluation of ovarian tumor. Methods: It was a prospective cross sectional study done in Paropakar Maternity and Women’s Hospital from May to August 2018. During the study, 72 women with ovarian tumor were analyzed. RMI5 was calculated using the ultrasound score, Doppler score, menopausal status and CA125. Cut-off of 200 was used for malignancy discrimination. Chi square test was used to calculate the statistical significance which was set at 0.05. Receiver Operator Characteristics curves for RMI and its individual parameters were plotted using SPSS. Results: There were 72 ovarian tumors operated in four months and mean age was36 years with 10 (14%) at post-menopause. The mean value of RMI 5 was 38 for benign tumors, 80 for borderline tumors and 899 for malignant tumors. The area under curve for RMI 5 was 0.993 for cut-off of 200. The diagnostic accuracy of RMI 5 was 94.4 which was similar to that of Doppler score 2 (94.7) while it was much higher than that of the rest of the parameters (CA-125: 72, ultrasound score: 87 and postmenopausal status: 88.9). Conclusions: RMI 5 is better for malignancy prediction of ovarian masses instead of individual parameters like menopausal status, CA125 and ultrasound score.

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Section: Resultsmentioning

confidence: 48%

Modified Risk of Malignancy Index (RMI 5) in ovarian tumor

Joshi

Baral

2021

Nepal J Obstet Gynaecol

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“…As five-year survival in stage Ia is 80% we assume that this score will help in preoperative provisional diagnosis with early intervention. 5 The most common benign ovarian tumour was serous cystadenoma and malignant OC was serous cystadenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Preoperative detection is imperative from intervention point of view because in stage Ia (FIGO 2014) ovarian tumour the cure rate is more than 80%. 5 Moreover, it will prevent morbid surgeries and cost of therapy in benign ovarian tumour. The screening tests available are tumour markers (CA-125), Ultrasonography (USG), multimodality screening (CA-125 followed by USG), CT scan and MRI.…”

Section: Introductionmentioning

confidence: 99%

Study of validity of risk of malignancy index in perimenopausal women with ovarian mass in a tertiary care hospital in India

Mahadik

Singh

Swami

2020

Int J Reprod Contracept Obstet Gynecol

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Background: Ovarian carcinoma is a silent killer because it presents in advanced stage. In India, it ranks third after carcinoma cervix and breast. Incidence of ovarian cancer is 5.4-8.0 per 100,000 in India. Various versions of risk of malignancy index have been studied to show its validity in different settings. We have studied third version of risk of malignancy index in a resource poor setting in India.Methods: In this prospective observational study 74 perimenopausal and postmenopausal women with ovarian mass were recruited. Menopausal score (M), Ultrasonography score (U) and CA-125 are components of Risk of Malignancy Index 3. Patients underwent preoperative ultrasonography and CA-125 level was assessed. Scores of M 1-3, U 1-3 and absolute value of CA-125 was multiplied. This product was value of Risk of Malignancy Index 3. If it is less than 250 it suggests absence of malignancy and more than 250 strongly suggests malignancy. Results were confirmed by histopathology.Results: Fifty six percent women were cancer positive. Ovarian malignancy was more common in postmenopausal age group. Ultrasonography and CA-125 had high sensitivity of 90% but poor specificity. Risk of malignancy index 3 had a sensitivity, specificity, positive predictive value and negative predictive value of 90%, 91%, 78% and 96% respectively at a cut off value of 250.Conclusions: Risk of malignancy index was concluded to be a multimodal approach with better diagnostic scoring index in preoperative stage in women of ovarian masses. It is simple and easily applicable clinical tool in resource poor setting.

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“…This signifies the need for a preoperative determination of the nature of an ovarian tumor before deciding on the appropriate plan of management. 5 The primary objective was to assess the efficacy of morphological index as a method to predict malignancy in sonographically confirmed ovarian tumors.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of morphological indexing of ovarian tumor: preoperative determination of risk of malignancy

Aishwarya

Sasikala

Dilshath

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONOvarian cancers ranks fifth in cancer death worldwide and in India it ranks third among the female genital tract malignancies.1 In India, the annual percentage of increase in age standardised incidence rates ranged from 0.7% to 2.4 %.2,3 Of all gynaecological cancers, ovarian malignancies represent the greatest clinical challenge, because of greater range and variety of tumors with uncertain origin, no known premalignant lesion and variability in the rate of disease progression. Around 70% of patients with ovarian tumors are diagnosed only at advanced stages due to unavailability of effective screening method and lack of specific clinical presentations at early stage of the disease where the prognosis is poor. In contrast, women with early stage ovarian cancer have an excellent survival rates. 4 Hence, there has been an increased interest in the development of investigations that can detect ovarian cancer at an early stage. Moreover, pre-operative knowledge about the nature of the ovarian tumour is necessary to plan surgery. A malignant tumour requires radical surgery, chemotherapy and counselling regarding the survival rates in contrast to the benign tumors that can be managed with simple laparoscopic cystectomy or laparotomy. This signifies the need for a preoperative ABSTRACT Background: Ovarian cancers ranks fifth in cancer death worldwide and in India it ranks third among the female genital tract malignancies. Objective of present study was to assess prospectively the efficacy of morphological indexing (MI) as a method to predict malignancy in sonographically confirmed ovarian tumors. Methods: A prospective study conducted in a tertiary care hospital in Tamil Nadu from September 2011 to August 2012. The risk of malignancy is preoperatively assessed in 136 patients with ovarian tumour using a morphological index based on tumour volume and wall structure. Each tumour was assigned a score of 0 to 10 based on increasing volume and morphologic complexity. The efficacy of the index was assessed by histopathological examination of the tumour. Results: The benign tumours had a mean MI score of 4.3 and malignant tumours had a mean of 8.3 which was statistically significant. Of the 54 tumours with MI <5, only 2 (3.7%) were malignant where else out of the remaining 82 tumours with MI >5, 54 (51.2%) were malignant. With MI >5 as a predictor of malignancy the present study had a Sensitivity-95.5%, Specificity-56.5%, Positive predictive value-51.2%, Negative predictive value-94%, and Accuracy-68%. Conclusions: Morphological index is a simple, valuable and inexpensive diagnostic tool to rule out malignancy in pre operative evaluations of ovarian tumors.

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Evaluation of the validity of risk malignancy index in clinically diagnosed ovarian masses and to compare it with the validity of individual constituent parameter of risk malignancy index

Cited by 4 publications

References 11 publications

Modified Risk of Malignancy Index (RMI 5) in ovarian tumor

Modified Risk of Malignancy Index (RMI 5) in ovarian tumor

Study of validity of risk of malignancy index in perimenopausal women with ovarian mass in a tertiary care hospital in India

Efficacy of morphological indexing of ovarian tumor: preoperative determination of risk of malignancy

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