Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients

Kıskaç, Muharrem; Zorlu, Mehmet; Çakırca, Mustafa; Karatoprak, Cumali; Kesgin, Sıdıka; Büyükaydın, Banu; Yavuz, Erdinç; Ardıç, Cüneyt; Camli, Ahmet Adil; Çıkrıkçıoğlu, Mehmet Ali

doi:10.1016/j.ando.2014.07.112

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…It is reported in various studies that vitamin D deficiency is more common in women than in men, and that women possess more severe forms of the disease. Women generally spend most of their time for indoor activities, and thus they are not exposed to sunlight efficiently; this may be the reason of more common vitamin D deficiency reported in women in various studies [10][11][12]. In our study, vitamin D and vaspin levels correlated positively and significantly, whereas there was an inverse and significant relation between vitamin D and omentin values.…”

mentioning

confidence: 47%

Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women

Zorlu

Kıskaç

Çakırca

et al. 2016

Exp Clin Endocrinol Diabetes

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Vitamin D may affect the release of adipokines from the adipose tissue, and this effect may be in a negative or positive manner. This effect of vitamin D may probably be mediated via vitamin D receptors exhibited in the adipose tissue, or via mechanisms not identified yet. The results of this study suggested that there was a significant, positive correlation between serum vitamin D levels and vaspin, whereas a significant, negative correlation between vitamin D levels and omentin. Further studies on larger series are needed in order to confirm these results.

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mentioning

confidence: 47%

Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women

Zorlu

Kıskaç

Çakırca

et al. 2016

Exp Clin Endocrinol Diabetes

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“…At the same time, insulin is an important modulator of apelin expression and secretion, and high concentrations of apelin are observed in hyperinsulinemia, indicating a correlation between apelin and insulin [19]. Recent studies have found high concentrations of apelin in obese individuals and in type 2 diabetes patients, while showing correlations of apelin with homeostatic model assessment-insulin resistance, body mass index, total cholesterol, low-density lipoprotein cholesterol, and insulin [20, 21]. Based on this evidence, apelin appears be a relevant indicator for metabolic syndrome and related to type 2 diabetes [22].…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial

et al. 2019

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BackgroundThe risk for obesity-related diseases increases with the prevalence of obesity. In obesity, adipokines secreted from adipose tissue induce inflammation, causing adverse effects. Recently, adipokines such as apelin, visfatin, and chemerin have been studied. Long-term resistance training improves health in middle-aged women by improving metabolic risk factors, body composition, and muscle strength. However, there is still a lack of evidence on the association of apelin concentration with different exercise types in middle-aged obese women This study aimed to investigate the effects of 8 weeks of aerobic and resistance exercises on apelin-12 and apelin-36 levels and thereby verify the effects of different exercise types in obese, middle-aged women.MethodsParticipants were middle-aged women aged 50–61 years, with no experience of systematic exercise in the last 6 months, and met the WHO obesity criteria for the Asia-Pacific region of waist circumference ≥ 80 cm and body fat percentage ≥ 30%. Subjects were selected and allocated to the aerobic exercise, resistance exercise, or no exercise group by block randomization. Body weight, body fat, and body mass index were measured by bioelectrical impedance analysis. Analysis of variance, the t-test, and Tukey’s post-hoc test were performed.ResultsA total of 24 participants were selected with eight participants in each group. Both aerobic and resistance exercises were effective in altering the physical composition, showing significant decreases in weight, waist circumference, BMI, and body fat. The aerobic and resistance exercise group showed a significant, positive change in apelin-12 levels.ConclusionsIn obese individuals, aerobic and resistance exercise were effective in improving obesity and reducing blood apelin-12 concentration, which is closely correlated with indicators of metabolic syndrome.Future research should focus on comparing the response of apelin to exercise in obese subjects treated with only dietary control and the response in the obese subjects of different ages and sex.Trial registrationNo. 1040917–201,506-BR-153-04, Clinical Research Information Service (CRIS), Republic of Korea (05 October 2018, retrospectively registered).

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“…Some studies have suggested that high MPV values demonstrate increased platelet activity in patients with diabetes and are associated with insulin resistance. 31 The correlation between MPV levels and Bell’s palsy has not been documented in the literature. There were no significant intergroup differences in MPV values in the present study, in agreement with the results reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of neutrophil lymphocyte ratio and mean platelet volume in Bell’s palsy: Comparison of diabetic and non-diabetic patients

İnan

Jafarov

2023

Brazilian Journal of Otorhinolaryngology

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Evaluation of the relationship between serum apelin levels and vitamin D and mean platelet volume in diabetic patients

Cited by 7 publications

References 22 publications

Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women

Evaluation of the Relation between Vitamin D and Serum Omentin and Vaspin Levels in Women

Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial

Prognostic role of neutrophil lymphocyte ratio and mean platelet volume in Bell’s palsy: Comparison of diabetic and non-diabetic patients

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