Evaluation of the photoprotective effect of oral vitamin E supplementation

Werninghaus, K.

doi:10.1001/archderm.130.10.1257

Cited by 65 publications

(55 citation statements)

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“…Coapplication of vitamin E and β-carotene tended to be superior to β-carotene treatment alone, but the difference was statistically not significant (143). Vitamin E alone, in the form of α-tocopheryl acetate, was administered orally at 400 IU/d over a period of six months, but no significant protection was achieved (170). Parameters determining the bioavailability of tocopherol in human skin are not yet known.…”

Section: Tocopherol and Ascorbatementioning

confidence: 98%

Nutritional Protection Against Skin Damage From Sunlight

2004

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▪ Abstract The concept of systemic photoprotection by dietary means is gaining momentum. Skin is continuously exposed to ultraviolet (UV) radiation, the major cause of skin disorders such as sunburn, photodamage, and nonmelanoma skin cancer. Most of the erythemal annual UV dose is encountered under nonvacation conditions, when no sunscreen is applied. In the absence of topically added compounds, skin protection depends solely on endogenous defense. Micronutrients can act as UV absorbers, as antioxidants, or can modulate signaling pathways elicited upon UV exposure. UV-induced erythema is a suitable parameter to assess photoprotection. Dietary protection is provided by carotenoids, tocopherols, ascorbate, flavonoids, or n-3 fatty acids, contributing to maintenance resistance as part of lifelong protection.

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Section: Tocopherol and Ascorbatementioning

confidence: 98%

Nutritional Protection Against Skin Damage From Sunlight

2004

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“…The results of these studies were, however, inconclusive and contradictory (La Ruche and Cesarini, 1991;Werninghaus et al, 1994;Garmyn et al, 1995;Gollnick et al, 1996;Eberlein-König et al, 1998;Fuchs & Kern, 1998;Wolf et al, 1988;Lee et al, 2000;Stahl et al, 2000). Moreover, all these studies used synthetic (pure) compounds in relatively high dosages compared to the normal physiological range of vitamins and carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Determinants of skin sensitivity to solar irradiation

et al. 2003

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Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to UV irradiation, as assessed by the minimal erythema dose (MED). Design: We conducted a cross-sectional study among 335 volunteers. Sensitivity to UV irradiation was established through assessment of the MED. Phenotypical determinants, including skin melanin content, hair color and iris color were determined by skin reflectance spectrometry, a subjective questionnaire and an objective classification system, respectively. Furthermore, dietary exposure was measured by carotenoids, vitamin C, retinol and a-tocopherol in serum. Results: Male subjects were found to be more sensitive to UV irradiation; that is, the MED was significantly lower compared to female subjects. Skin melanin content, which was positively associated with iris color in both sexes and with hair color in men, was the main phenotypical determinant of sensitivity to UV irradiation. No associations were found between serum carotenoids and MED in the total study group. Vitamin C was inversely associated with MED. However, associations between carotenoids concentrations and MED showed a positive trend in subjects with melanin values above and a negative trend in subjects below the median after adjustment for gender and total cholesterol. Conclusions: Skin melanin content and gender are important determinants of sensitivity to UV irradiation. No relation was found between serum carotenoids and MED in the total study group. The inverse association between vitamin C and MED was against our hypothesis. For the modifying effect of melanin on the association between carotenoids and MED, we do not have a clear biological explanation.

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“…photoprotection against UV radiation damage of the DNA, lipids and living cells [4,59,87,109,123,130,138,[144][145][146][147][148] , diminishing the risk of UV-induced erythema [6,21,48,50,149] , stimulation of the synthesis of collagen and cell proliferation [150] and increasing the density of Langerhans cells [8], was observed. MED increase after the supplementation of the mixture of antioxidant substances was also reported [5,10,130,144] , whereas some papers [8,112,138,151] showed no statistically signifi cant differences between the MED and antioxidant supplementation.…”

Section: Systemic Application Of Synthetic and Extracted Antioxidantsmentioning

confidence: 88%

“…Also, there are a few papers that indicated the absence of a positive action of supplemented antioxidants on skin health [112,119,138,149,151] .…”

Section: Systemic Application Of Synthetic and Extracted Antioxidantsmentioning

confidence: 99%

Effect of Supplemented and Topically Applied Antioxidant Substances on Human Tissue

Darvin

Zastrow

Sterry

et al. 2006

Skin Pharmacol Physiol

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Systemic and topical application of antioxidant substances for the medical treatment and prophylaxis of many diseases as well as additional protection of the skin against the destructive action of free radicals and other reactive species has become very popular during the past years. Stimulated by the positive results of a fruit and vegetable diet in supporting medical treatment and in cosmetics, artificial and extracted antioxidant substances have been broadly applied. Surprisingly, not only positive but also strong negative results have been obtained by different authors. According to study reports artificial and extracted antioxidant substances support different kinds of medical therapies, if they are applied in mixtures of different compounds at low concentration levels. In the case of the application of high concentration of some single compounds, side effects were often observed. Regarding skin treatment by systemically applied antioxidant substances for cosmetic purposes, positive cosmetic effects as well as no effects, but almost no side effects, apart from a number of allergic reactions, were reported. One reason for this seems to be the lower concentration of systemically applied antioxidant substances in comparison with a medical application. Topical application of antioxidant substances is closely related to cosmetic treatment for skin protection and anti-aging. Positive results were also obtained in this case. The present review is an attempt to classify and summarize the published literature concerning the efficiency of action of systemic and topical applications of antioxidant substances, such as carotenoids and vitamins, on human organism and especially on the skin. The available literature on this topic is very extensive and the results are often contradictory. Nevertheless, there are some clear tendencies concerning systemic and topical application of antioxidant substances in medicine and cosmetics, and we summarize them in the present paper.

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Evaluation of the photoprotective effect of oral vitamin E supplementation

Cited by 65 publications

References 0 publications

Nutritional Protection Against Skin Damage From Sunlight

Nutritional Protection Against Skin Damage From Sunlight

Determinants of skin sensitivity to solar irradiation

Effect of Supplemented and Topically Applied Antioxidant Substances on Human Tissue

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