Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects

Tsujimoto, Hiroyuki; Hara, Kaori; Tsukada, Yusuke; Huang, Chunmao; Kawashima, Yasunaru; Arakaki, Minoru; Okayasu, Hajime; Mimura, Haruko; Miwa, Nobuhiko

doi:10.1016/j.bmcl.2007.06.057

Cited by 61 publications

(27 citation statements)

References 9 publications

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“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In particular, cosmetic application of nanoparticles is regarded as the best technology to upgrade the performance of cosmetic products and to meet the consumer's needs. 19 For example, Popov et al showed that potential application of zinc oxide or titanium oxide nanoparticles for sunscreen has benefit to attenuate ultraviolet light by absorption and scattering.…”

Section: Discussionmentioning

confidence: 99%

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Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Lee¹,

Jeong²,

Choi³

2011

IJN

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Background: p-Phenylenediamine (PDA) or its related chemicals are used more extensively than oxidative hair dyes. However, permanent hair dyes such as PDA are known to have potent contact allergy reactions in humans, and severe allergic reactions are problematic. Methods: PDA-incorporated nanoparticles were prepared based on ion-complex formation between the cationic groups of PDA and the anionic groups of poly(γ-glutamic acid) (PGA). To reinforce PDA/PGA ion complexes, glycol chitosan (GC) was added. PDA-incorporated nanoparticles were characterized using field-emission scanning electron microscopy, Fourier-transform infrared (FT-IR) spectroscopy, dynamic light scattering, and powder X-ray diffractometry (XRD). Results: Nanoparticles were formed by ion-complex formation between the amine groups of PDA and the carboxyl groups of PGA. PDA-incorporated nanoparticles are small in size (,100 nm), and morphological observations showed spherical shapes. FT-IR spectra results showed that the carboxylic acid peak of PGA decreased with increasing PDA content, indicating that the ion complexes were formed between the carboxyl groups of PGA and the amine groups of PDA. Furthermore, the intrinsic peak of the carboxyl groups of PGA was also decreased by the addition of GC. Intrinsic crystalline peaks of PDA were observed by XRD. This crystalline peak of PDA was completely nonexistent when nanoparticles were formed by ion complex between PDA, PGA, and GC, indicating that PDA was complexed with PGA and no free drug existed in the formulation. During the drug-release experiment, an initial burst release of PDA was observed, and then PDA was continuously released over 1 week. Cytotoxicity testing against HaCaT human skin keratinocyte cells showed PDA-incorporated nanoparticles had lower toxicity than PDA itself. Furthermore, PDA-incorporated nanoparticles showed reduced apoptosis and necrosis reaction at HaCaT cells. Conclusion:The authors suggest that these microparticles are ideal candidates for a vehicle for decreasing side effects of hair dye.

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Section: Discussionmentioning

confidence: 99%

“…15 Furthermore, the intrinsic small size of nanoparticles is regarded as playing an important role in skin penetration and dermal drug delivery. 16 In this study, the formation of nanoparticles incorporating PDA was investigated.…”

Section: Introductionmentioning

confidence: 99%

Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Lee¹,

Jeong²,

Choi³

2011

IJN

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“…Finasteride, a 5-α reductase inhibitor preventing the peripheral conversion of testosterone to dihydrotestosterone, has a variety of unwanted side effects following oral administration; encapsulation of finasteride into topical liquid crystalline nanoparticles has been proposed as a viable alternative to oral administration in order to maintain high skin retention in the scalp, enable a lower dosing frequency and minimize significant side effects including mood disturbances, gynecomastia and erectile dysfunction [48]. Furthermore, poly(lactic-co-glycolic acid) nanoparticles loaded with a variety of hair growing ingredients (hinokitiol, gylcyrrhetinic acid and 6-Benzylaminopurine) exerted a 2-2.5 fold greater scalp-pore permeability compared to controls and enhanced hair growth by accelerating the transition from the telogen to anagen phase of the hair cycle ( Figure 5) [49]. In a second study, nanocapsules containing hinokitiol infused into a hair cleansing shampoo or hair tonic resulted in significantly higher degree of hair growth in vivo compared to saline and minoxidil solution controls [50].…”

Section: Hair Growth and Removalmentioning

confidence: 99%

“…Taken together, these results suggest that topically applied nanomaterials are successful carriers for hair-altering ingredients, representing a potentially new therapeutic opportunity for hair loss and hair removal. Reprinted with permission from [49], published by Elsevier Ltd., 2007.…”

Section: Hair Growth and Removalmentioning

confidence: 99%

Nanotechnology-Based Cosmetics for Hair Care

2015

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Abstract:Hair is a significant indicator of health and can have a major impact on an individual's cosmetic appearance. Research within the cosmetics industry has revealed that when nanomaterials are engineered into hair care, they can enhance the benefits of active ingredients in order to improve hair cosmesis. Within the cosmetics arena, the unique size and intrinsic properties of nanoparticles can be tailored to target the hair follicle and shaft. This review aims to provide an overview of cosmetic nanocarriers that can be employed to improve the appearance of hair.

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“…[15][16][17] Recently, the use of drug nanoparticles has been shown to improve drug delivery to the skin. [18][19][20][21][22][23][24] Surface area enhancement due to the size reduction of drug crystals or their amorphous formation may affect skin permeation behavior. Nano-sized drug may also contribute to the enhanced retention, which is applicable for the topical administration.…”

Section: )mentioning

confidence: 99%

Effect of Particle Size on Skin Permeation and Retention of Piroxicam in Aqueous Suspension

Moribe

Shibata

Furuishi

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Reduction in particle size of hydrophobic drugs has attracted interest as a way to improve their dissolution and absorption properties.1-4) Grinding is one of the methods used to reduce the size of drug crystals. Cogrinding of a hydrophobic drug with a hydrophilic polymer and surfactant appears to be an effective method for the preparation of drug nanoparticles and stable nanosuspensions.5-8) Using a drug/ polyvinylpyrrolidone K17 (PVP K17)/sodium dodecyl sulfate (SDS) ternary ground mixture (GM) at a weight ratio of 1/3/1, more than 20 kinds of drugs have been effectively reduced to nano-order particle size.6) When a probucol/PVP K12/SDS GM suspension was orally administered to rats, plasma concentration increased as particle size decreased.

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Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects

Cited by 61 publications

References 9 publications

Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Nanotechnology-Based Cosmetics for Hair Care

Effect of Particle Size on Skin Permeation and Retention of Piroxicam in Aqueous Suspension

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Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects

Cited by 61 publications

References 9 publications

Hair dye-incorporated poly-&gamma;-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Hair dye-incorporated poly-&gamma;-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Nanotechnology-Based Cosmetics for Hair Care

Effect of Particle Size on Skin Permeation and Retention of Piroxicam in Aqueous Suspension

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Product

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Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation