Evaluation of the modulation of nitric oxide synthase expression in the cerebellum of diabetic albino rats and the possible protective effect of ferulic acid

Elhessy, Heba M.; Eltahry, Huda; Erfan, Omnia S.; Mahdi, Mohamed R.; Hazem, Noha M.; El-Shahat, Mona A.

doi:10.1016/j.acthis.2020.151633

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…Singh et al [ 314 ] indicated that ferulic acid is a phenol derivative from natural sources and applied it as a potential pharmacophore that exerts multiple pharmacological properties such as neuroprotection, Aβ aggregation modulation, antioxidant, and anti-inflammatory. Ferulic acid increases cerebellar functional and histopathological changes induced by diabetes, which can be attributed to its antioxidative effect and its ability to modulate nitric oxide synthase (NOS) isoforms [ 315 ]. Ramar et al [ 316 ] showed that ferulic acid and resveratrol revealed antioxidant as well as antidiabetic effects, consequently modulating liver, kidney, and pancreas damage caused by alloxan-induced diabetes, possibly via inhibition of the proinflammatory factor, NF-KB.…”

Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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“…Ferulic acid is a simple phenolic acid commonly present in cereals and is known to have a free radical-scavenging effect (Vashistha et al, 2017). Several therapeutic properties of ferulic acid, including cardioprotective (Alam et al, 2013), anticancer (Gao et al, 2018), and neuroprotective (Elhessy et al, 2020) properties have been reported. Elhessy et al (2020) observed that diabetic rats treated with ferulic acid showed a reduction in degenerative alterations in the cerebellum with a reduced the levels in the markers of oxidative stress.…”

Section: Physicochemical and Biochemical Properties Of Craft Beersmentioning

confidence: 99%

“…Rutin was found in B1, B3, B4, B5, and B6, gallic acid in B3, B4, and B5, and kaempferol in B5 and B6. Rutin is a flavonoid found abundantly in citrus fruits (Elhessy et al, 2020). Studies have reported therapeutic effects of rutin on colonic inflammation, oxidative stress, and dysbiosis of the intestinal microbiota in mice (Liu et al, 2022), as well as anti-inflammatory effects of rutin on macrophages and T cells (Ganesan et al, 2021).…”

Section: Physicochemical and Biochemical Properties Of Craft Beersmentioning

confidence: 99%

Commercial craft beers of midwest Brazil: biochemical and physicochemical properties and their relationship with its sensory profile

et al. 2023

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Faced with changes in eating habits, consumers currently seek to enjoy moderate consumption of healthy food products that results in sensory pleasure. Here, our study aimed to evaluate the biochemical and physicochemical properties and sensory profile of craft beers produced in the Brazilian Midwest region. Our evaluation of the beverages revealed different physicochemical characteristics such as alcohol content, soluble solids, titratable acidity in citric acid, and dry extract percentage, with values ranging between 4.06-6.13%, 5.13-10.98 °Brix, 1.71-3.45%, and 3.38-7.99%, respectively. Moreover, the average density of the beverages was 0.9906 g/cm 3 . In addition, the antioxidant activity and total phenolic of the beverages ranged between 14.28-20.46 mMol of Trolox/100 mL and 74.84-108.45 mg/100 g, respectively. Phenolic compounds that are essential in human nutrition, such as epicatechin, catechin, gallic acid, p-coumaric acid, caffeic acid, ferulic acid, rutin, and kaempferol, were identified in the beverages. Regarding the sensory profile of the craft beers, the beers had an average acceptability index of 75.11% for appearance, 70.24% for aroma, 60.43% for flavor, and 73.53% for texture. Our study demonstrated a correlation between chemical composition and acceptability index of beer, indicating a preference for lighter colored, fuller, and less acidic beers.

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“…HAs, including CA, CQA, GA, and FA, exert a wide variety of biological antioxidant, anti-inflammatory, antimicrobial, antiallergic, hepatoprotective, anticarcinogenic, antithrombotic, and antiviral activities. Studies in rats and piglets suggest that HAs play a role in increasing sperm viability, vasodilatory actions, enzyme activity modulation, transcriptional factor activation, gene expression, and signal transduction [161][162][163][164].…”

Section: Potential Health Benefitsmentioning

confidence: 99%

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

et al. 2022

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Cardiovascular and metabolic diseases are a leading cause of death worldwide. Epidemiological studies strongly highlight various benefits of consuming colorful fruits and vegetables in everyday life. In this review, we aimed to revisit previous studies conducted in the last few decades regarding green-colored foods and their bioactive compounds in consideration of treating and/or preventing cardiovascular and metabolic diseases. This review draws a comprehensive summary and assessment of research on the physiological effects of various bioactive compounds, mainly polyphenols, derived from green-colored fruits and vegetables. In particular, their health-beneficial effects, including antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, cardioprotective, and lipid-lowering properties, will be discussed. Furthermore, the bioavailability and significance of action of these bioactive compounds on cardiovascular and metabolic diseases will be discussed in detail.

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Evaluation of the modulation of nitric oxide synthase expression in the cerebellum of diabetic albino rats and the possible protective effect of ferulic acid

Cited by 8 publications

References 54 publications

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Commercial craft beers of midwest Brazil: biochemical and physicochemical properties and their relationship with its sensory profile

Physiological Effects of Green-Colored Food-Derived Bioactive Compounds on Cardiovascular and Metabolic Diseases

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