Evaluation of the mediastinum by gallium-67 scintigraphy in lung cancer

Fosburg, Richard G.; Hopkins, G. Bruce; Kan, Michael K.

doi:10.1016/s0022-5223(19)40991-4

Cited by 46 publications

(7 citation statements)

References 23 publications

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“…Therefore, one truly important part of preoperative evaluation is the exclusion of metastatic spread. The meth ods and extent of a search for metastases are a maUer of con troversy (3,4,5,7,10,12). Some investigators (3, 7) recommend routine scanning of multiple organs, including Gallium-67 tot al body scan, for as nearly complete staging as possible.…”

Section: Discussionmentioning

confidence: 99%

Extended Resections of Locally Advanced Stage III Lung Cancer

Weissberg¹

1981

Thorac cardiovasc Surg

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Lung cancer invading extrapulmonary structures was resected in 13 patients, with one hospital death. The 12 survivors lived from 6 months to 53 months; their quality of life markedly improved. Three are still alive, with one apparent cure. In treating advanced lung cancer one must distinguish between local invasion and metastatic spread. In the absence of metastases, there is virtually no limit to resectability of the neoplasm, except extensive invasion of vital organs. Metastases preclude curability; in their presence useless traumatic resections should be avoided. Resectability is not necessarily related to the size of the neoplasm. A very small growth may not be resectable, while a hugh tumor confined to lung parenchyma may be amenable to surgical therapy.

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Section: Discussionmentioning

confidence: 99%

Extended Resections of Locally Advanced Stage III Lung Cancer

Weissberg¹

1981

Thorac cardiovasc Surg

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“…1 Local or metastatic rib destruction 2 Bronchostenosis or deformity of trachea, carina, main bronchi, or proximal segmental bronchi 3 Cavitation in mass with thick irregular walls 4 Spiculation of irregular margin ofmass 5 Mass with hilar enlargement 6 Lobulation of mass 7 Lobar or segmental collapse with any of the above 8 Mass accompanied by linear shadows characteristic of lymphatic infiltration confirmed, despite appearances of extrinsic compression and distortion of the bronchial tree; these cases were categorised as bronchoscopy negative for the purposes of this study.…”

Section: Methodsmentioning

confidence: 99%

Assessment of conventional tomography and fibreoptic bronchoscopy in the diagnosis of potentially malignant chest opacities.

Bagg¹,

Cox²,

Russell³

et al. 1984

Thorax

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Conventional chest tomography and fibreoptic bronchoscopy were performed in 100 patients with a localised chest abnormality on their chest radiographs who had been referred with a possible diagnosis of bronchial carcinoma. Carcinoma was eventually confirmed in 74 cases and in 26 the lesion proved to be benign. The accuracy of tomography in the overall series was 83%, with a sensitivity of 92% and a specificity of 58%. These figures compare favourably with the results of other imaging techniques used in the diagnosis of bronchial carcinoma. In 50 patients bronchoscopy did not suggest carcinoma and in this group of patients 24 had a carcinoma and 26 a benign lesion. The accuracy of tomography in the bronchoscopy negative patients was 74%, the major source of error being the false positive category. The lesion eventually proved to be benign in 33 % of the cases where tomography suggested malignancy, but when the tomograms suggested that the lesion was benign a tumour was found to be present in only 12% of cases.

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“…In the past decade, most emphasis was therefore put on using gallium scans for detecting hilar and mediastinal metastases in patients with lung cancer (Deland 1976;Alazraki 1978;De Meester 1979;Fosburg 1979;Waxman 1982;Neumann 1981;Lunia 1981;Lesk 1982;McKenna 1985;Klech 1986a). However, there is considerable variation in the figures reported so far.…”

Section: Mediastinal Stagingmentioning

confidence: 99%

Thoracic imaging with 67gallium

et al. 1987

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In the past, gallium-67 imaging has undergone several ups and downs related to its clinical importance. After a period of initial enthusiasm, its role and indications are now established. At present, there are two fields of clinical interest for 67Ga-imaging: (1)mediastinal staging in bronchogenic carcinoma and the staging of malignant lymphoma; (2) assessment of activity in interstitial lung diseases, especially sarcoidosis and inflammatory lung disorders. The advantage of 67Ga-imaging is that it is highly sensitive for the detection of neoplastic and inflammatory processes, independent of anatomical barriers. Particularly with the challenge of AIDS, 67Ga-imaging will gain increasing importance in the future. The low specificity of gallium for detecting underlying disorders precludes its use as a primary diagnostic tool. Therefore, and because of the cost and radiation load, the indications for application will have to be selected very carefully.

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Evaluation of the mediastinum by gallium-67 scintigraphy in lung cancer

Cited by 46 publications

References 23 publications

Extended Resections of Locally Advanced Stage III Lung Cancer

Extended Resections of Locally Advanced Stage III Lung Cancer

Assessment of conventional tomography and fibreoptic bronchoscopy in the diagnosis of potentially malignant chest opacities.

Thoracic imaging with 67gallium

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