Evaluation of the lemongrass plant (Cymbopogon citratus) extracted in different solvents for antioxidant and antibacterial activity against human pathogens

Balakrishnan, Balachandar; Paramasivam, S.; Arulkumar, Abimanan

doi:10.1016/s2222-1808(14)60428-x

Cited by 94 publications

(80 citation statements)

References 21 publications

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“…These results confirm, corroborating with Cheel et al (2005), that found the main ERs eliminator both in the infusion and in the decoction of the Cymbopogom citratus extract, but with important differences in the relative proportions in each preparation. Although the presence of polyphenols and tannins is evidenced in the lemongrass, it is possible to point out the quantity of flavonoids both in the extract and in the infusion of this plant, fact which according to Balakrishnan, Paramasivam, and Arulkumar (2014), indicates an important antioxidant lemongrass activity, due to the fact that, these authors report that the flavonoids have strong activities of reactive oxygen species elimination, and it is effective regarding the cell protection against the oxidative damages.…”

Section: Resultsmentioning

confidence: 99%

Effect of the Cymbopogon citratus Infusion on the Activity of Acetylcholinesterase Enzyme and on the Redox Profile in Farmers’ Erythrocytes

Mori¹,

Horn²,

Oliveira³

et al. 2017

JAS

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Agrochemicals were more prominent in 1960, marked due to the agricultural modernization process. As a result of this widespread use for food production, there was also an increase in cases of intoxication caused by these agents which made it necessary to search for alternative therapies for agricultural workers. Thus, considering that phytochemical characterization revealed the presence of antioxidants in Cymbopogon citratus extract, the objective of this study was to evaluate the effect of this plant infusion on the enzyme acetylcholinesterase activity (AChE) and on the redox response in farmers' erythrocytes. These erytrocytes were processed and subjected to treatment with the Cymbopogon citratus infusion (5, 10, 25 and 50 g/L). In these samples the following were determined: the AChE enzyme activity, the levels of thiobarbituric acid reactive substances (TBARS), protein carbonyls (CPs) and reduced glutathione (GSH). In general, it was discovered that the inhibition of AChE activity is negative regarding to the increase of protein carbonyl levels and positive regarding the GSH levels. In addition, Cymbopogon citratus infusions could not even reverse this inhibition or the high levels of TBARS and CPs. On the other hand, levels of GSH were increased by infusions demonstrating the increased antioxidant activity in rural workers' erythrocytes.

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Section: Resultsmentioning

confidence: 99%

Effect of the Cymbopogon citratus Infusion on the Activity of Acetylcholinesterase Enzyme and on the Redox Profile in Farmers’ Erythrocytes

Mori¹,

Horn²,

Oliveira³

et al. 2017

JAS

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“…Lemongrass is a perennial herb used mainly for the extraction of its oil, which is us aroma in the kitchen and as a fragrance in cosmetics. Lemongrass has been used for years, e in Southeast Asia, for its analgesic and anti-inflammatory properties [59]. Lemongrass oil citral, which gives it the distinctive aroma and perfume and is a mixture of aldehydes that same molecular formula but different structure, the trans isomer geranial and the cis isom Citral activates PPAR-γ, which inhibits the expression of pro-inflammatory cytokines, such and IL-6, and suppresses the activity of the COX-2 promoter [60].…”

Section: Lemongrassmentioning

confidence: 99%

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

et al. 2020

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The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-γ, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-γ also represses the inflammatory process. Similarly, the PPAR-γ agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-γ, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-γ activation. Here, we review the main synthetic and nutritional PPAR-γ ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.

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“…One of the main constituents of the many different species of lemongrass (genus Cymbopogon) is citral (3,7-dimethyl-2,6-octadien-1-al) [5][6]. Lemongrass oil has been found to contain up to 75-85% citral [7]. Lemongrass also contains z-citral, borneol, estragole, methyleugenol, geranyl acetate (3,7-dimethyl-2,6-octadiene-1-ol acetate), geraniol (some species higher in this compound than citral), beta-myrcene (MYR, 7-methyl-3-methylene-1,6 octadiene), limonenepiperitone, citronellal, citrat-2, alpha-terpineole, pinene, farnesol, proximadiol and (+)-cymbodiacetal [3].…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of essential oil from lemongrass (Cymbopogon citratus Stapf) as antioxidant agent

Anggraeni

Hidayat

Rachman

et al. 2018

AIP Conference Proceedings

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Abstract. Free radical induced oxidative stress that influences the occurrence of various degenerative diseases such as cancer, coronary heart disease and premature aging. In the case that body's antioxidant defense system does not have excessive antioxidants, additional natural antioxidant via food or other nutrients intake is needed. Stems of lemongrass Cymbopogon citratus Stapf are known to contain phenolic compounds that are known to have antioxidant activity. Lemongrass (Cymbopogon citratus Stapf ) plant is well known herb in Asia, espesially in Indonesia and used for cooking and has many health benefits. A study has been carried out to determine antioxidant potential of stems of lemongrass. In this the primary study is to examine essential oil Cymbopogon citratus Stapf from Cileles Jatinangor as an antioxidant agent. Essential oil of Cymbopogon citratus Stapf was isolated from 1272 g of dried stem by using Karlsruhe steam distillation methods with 0.24% in yield. The product of essential oil was also tested against antioxidant activity DPPH and resulted low activity compare to ascorbic acid and lemongrass oil standard as reference material.

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Evaluation of the lemongrass plant (Cymbopogon citratus) extracted in different solvents for antioxidant and antibacterial activity against human pathogens

Cited by 94 publications

References 21 publications

Effect of the Cymbopogon citratus Infusion on the Activity of Acetylcholinesterase Enzyme and on the Redox Profile in Farmers’ Erythrocytes

Effect of the Cymbopogon citratus Infusion on the Activity of Acetylcholinesterase Enzyme and on the Redox Profile in Farmers’ Erythrocytes

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

Bioactivity of essential oil from lemongrass (Cymbopogon citratus Stapf) as antioxidant agent

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