2008
DOI: 10.1590/s1415-47572008000300025
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Evaluation of the in vivo mutagenic potential of hydroalcoholic extracts of the northern highbush blueberry (Vaccinium corymbosum L. Ericales, Ericaceae) on peripheral blood cells of Swiss mice (Mus musculus Rodentia, Muridae)

Abstract: The northern highbush blueberry (Vaccinium corymbosum L. Ericales, Ericaceae) is very rich in anthocyanins, natural pigments which have strong antioxidant properties and potential health benefits, resulting in the worldwide use the blueberry as a medicinal plant. We investigated the mutagenic potential of simple hydroalcoholic extracts of V. corymbosum acutely administrated by gavage to Swiss mice at doses of 1 g kg -1 , 1.5 g kg -1 and 2 g kg -1 . Peripheral blood cells were collected 4 h and 24 h post-gavage… Show more

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Cited by 4 publications
(1 citation statement)
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“…There are several reports about the genotoxic or anti-genotoxic properties of species within Vaccinium sp. For example, it is stated that hydroalcoholic extracts of Vaccinium corymbosum L. fruits did not induce DNA damage in mice's peripheral blood leukocytes [68]. Anti-genotoxic properties of VM fruits from cisplatin-induced toxic effect were demonstrated in in vivo rat models [10].…”
Section: Discussionmentioning
confidence: 99%
“…There are several reports about the genotoxic or anti-genotoxic properties of species within Vaccinium sp. For example, it is stated that hydroalcoholic extracts of Vaccinium corymbosum L. fruits did not induce DNA damage in mice's peripheral blood leukocytes [68]. Anti-genotoxic properties of VM fruits from cisplatin-induced toxic effect were demonstrated in in vivo rat models [10].…”
Section: Discussionmentioning
confidence: 99%