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Cited by 39 publications
(31 citation statements)
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“…In another study, the result was similar, in which the dichloromethane fraction was more genotoxic than the ethanol extract [ 52 ]. This fact can be explained by the higher content of naphthoquinones in the fraction, which in addition to alkylating, can also stabilize the topoisomerase II-DNA complex, what is clarified under in silico studies by docking and molecular modeling [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
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“…In another study, the result was similar, in which the dichloromethane fraction was more genotoxic than the ethanol extract [ 52 ]. This fact can be explained by the higher content of naphthoquinones in the fraction, which in addition to alkylating, can also stabilize the topoisomerase II-DNA complex, what is clarified under in silico studies by docking and molecular modeling [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…Isoeleutherin, especially at the highest concentration, was responsible for a high level of DNA damage, as assessed by the comet assay. Another study using micronucleus assay, demonstrated relatively low genotoxic potential [ 28 ]. The comet assay assesses the rate of DNA damage before repair, while the micronucleus assesses the maintenance of damage after repair [ 53 ].…”
Section: Discussionmentioning
confidence: 99%
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