Evaluation of the efficacy of the Japanese rabies RC-HL strain vaccine in domestic dogs using past and present data: Prediction based on logistic regression and meta-analysis

Kwan, Nigel C. L.; Yamada, Akio; Suigiura, Katsuaki

doi:10.1016/j.prevetmed.2017.09.007

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Owner compliance to the current dog rabies vaccination policy is influenced by various factors including concerns over the dog's health (e.g., vaccine‐associated adverse event), opportunity cost of time and the false security that rabies will not occur in Japan (Supporting Information Table , Q4d). It has been highlighted that the current policy could be amended to one requiring less frequent boosters with the domestic RC‐HL strain vaccine currently in‐use, that is, a booster is required within one year after primary vaccination and then every two to three years (Kwan, Yamada, & Sugiura, ). Thus, the authors have conducted a benefit‐cost analysis to assess the economic efficiency of the current dog rabies vaccination policy in Japan (Kwan et al, ).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the contact rate between companion dogs during dog walking and the practices towards potential cases of rabies among dog owners in Japan

Kwan

Inoue

Yamada

et al. 2019

Zoonoses and Public Health

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This study aimed to examine the habits of dog walking in Japan using an internet survey of insured dog owners. About 96.4% of the respondents (n = 1,151) reported that they would take their dogs for a walk and they most frequently walk their dogs once or twice a day (75.9%) for 30 min to 1 hr (83.1%). The probability of a companion dog having contact with other dogs during dog walking was estimated to be 0.83 (95% confidence interval [CI]: 0.81–0.85), and the associated daily contact rate was estimated using log‐normal distribution with a mean of 2.73 (95% CI: 2.42–3.11) and a standard deviation (SD) of 6.39 (95% CI: 5.18–7.84). Multiple linear regression revealed that the contact rate is mainly influenced by the social behaviour of the owner and to a lesser degree by his/her demographic characteristics including the area of residence, the breed size of dog and the age of the owner. In addition, ten Likert items measured on a 5‐point scale were designed to assess the practices towards potential cases of rabies among dog owners. The respondents (n = 972) achieved a mean score of 2.99 (out of a full score of 4) with a SD of 0.90 in responding to situations related to dog bite incidents and injury from stray cat scratches during dog walking. They achieved a higher score in responding to situations related to sighting a stray or wild animal during dog walking and situations related to non‐specific clinical signs of rabies and bite injuries from stray dogs or wild animals during dog walking with a mean of 3.70 (SD = 0.58) and 3.84 (SD = 0.34), respectively. The level of best practice was also proved to be significantly associated with the demographic characteristics of the dog owner.

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Section: Discussionmentioning

confidence: 99%

Evaluating the contact rate between companion dogs during dog walking and the practices towards potential cases of rabies among dog owners in Japan

Kwan

Inoue

Yamada

et al. 2019

Zoonoses and Public Health

Self Cite

View full text Add to dashboard Cite

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“…In particular, it has been highlighted that the current annual vaccination policy could be amended to one requiring less frequent boosters with the domestic RC-HL strain vaccine currently in use, i.e. a booster is required within one year after primary vaccination and then every two to three years [29].…”

Section: Methodsmentioning

confidence: 99%

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan

2018

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Japan is one of the few rabies-free countries/territories which implement the policy of mandatory vaccination of domestic dogs. In order to assess the economic efficiency of such policy in reducing the economic burden of a future canine rabies outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic decision tree modelling. Input data derived from simulation results of published mathematical model, field investigation conducted by the authors at prefectural governments, literature review, international or Japanese database and empirical data of rabies outbreaks in other countries/territories. The current study revealed that the annual costs of implementing the current vaccination policy would be US$160,472,075 (90% prediction interval [PI]: $149,268,935–171,669,974). The economic burden of a potential single canine rabies outbreak in Japan were estimated to be US$1,682,707 (90% PI: $1,180,289–2,249,283) under the current vaccination policy, while it would be US$5,019,093 (90% PI: $3,986,882–6,133,687) under hypothetical abolition of vaccination policy, which is 3-fold higher. Under a damage-avoided approach, the annual benefits of implementing the current vaccination policy in expected value were estimated to be US$85.75 (90% PI: $55.73–116.89). The benefit-cost ratio (BCR) was estimated to be 5.35 X 10−7 (90% PI: 3.46 X 10−7–7.37 X 10−7), indicating that the implementation of the current policy is very economically inefficient for the purpose of reducing the economic burden of a potential canine rabies outbreak. In worse-case scenario analysis, the BCR would become above 1 (indicating economic efficiency) if the risk of rabies introduction increased to 0.04 corresponding to a level of risk where rabies would enter Japan in 26 years while the economic burden of a rabies outbreak under the abolition of vaccination policy increased to $7.53 billion. Best-case analysis further revealed that under relatively extreme circumstances the economic efficiency of the current policy could be improved by decreasing the vaccination price charged to dog owners, relaxing the frequency of vaccination to every two to three years and implementing the policy on a smaller scale, e.g. only in targeted prefectures instead of the whole Japan.

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“…In particular, it has been highlighted that the current annual vaccination policy could be amended to one requiring less frequent boosters with the use of the domestic RC-HL strain vaccine, i.e. a booster is required within one year after primary vaccination and then every two to three years [26].…”

Section: Methodsmentioning

confidence: 99%

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan

Kwan

Yamada

Sugiura

2018

Preprint

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20 Japan is one of the few rabies-free countries/territories which implement the policy 21 of mandatory vaccination of domestic dogs. In order to assess the economic 22 efficiency of such policy in reducing the economic burden of a future canine rabies 23 outbreak in Japan, a benefit-cost analysis (BCA) was performed using probabilistic 24 decision tree modelling. Input data derived from simulation results of published 25 mathematical model, field investigation conducted by the authors at prefectural 26 governments, literature review, international or Japanese database and empirical 27 data of rabies outbreaks in other countries/territories. The current study revealed 28 that the annual costs of implementing the current vaccination policy would be 29 US$160,472,075 (90% prediction interval [PI]: $149,268,669,974). The 30 economic burden of a potential canine rabies outbreak in Japan were estimated to

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Evaluation of the efficacy of the Japanese rabies RC-HL strain vaccine in domestic dogs using past and present data: Prediction based on logistic regression and meta-analysis

Cited by 5 publications

References 32 publications

Evaluating the contact rate between companion dogs during dog walking and the practices towards potential cases of rabies among dog owners in Japan

Evaluating the contact rate between companion dogs during dog walking and the practices towards potential cases of rabies among dog owners in Japan

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan

Benefit-cost analysis of the policy of mandatory annual rabies vaccination of domestic dogs in rabies-free Japan

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