Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial

Amirchaghmaghi, Maryam; Pakfetrat, Atessa; Delavarian, Zahra; Ghalavani, Hanieh; Ghazi, Ala

doi:10.7860/jcdr/2016/16338.7870

Cited by 33 publications

(97 citation statements)

References 22 publications

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“…Pain, the duration of the disease and spread of the lesions that first appeared on the heel may be the result of constant exposure to trauma due to lesion location in this case. While the etiology of the disease is not fully understood, studies show damage to keratinocytes following an immune reaction caused by CD8+ lymphocytes where production of multiple mediators (interleukin-12, interferon-γ, tumor necrosis factor-α, RANTES, MMP-9 and transforming growth factor-β1) gets suppressed and T-cell mediated immunity gets irregular [3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

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A case of erosive lichen planus with plantar involvement

Kılıç¹,

Baysak²,

Eşim³

et al. 2017

TURKDERM

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Section: Discussionmentioning

confidence: 99%

“…Erosive lichen planus (ELP) is a rare form of LP usually involving the oral mucosa and genital area 2 . Although the etiology of the disease is not fully understood, autoimmune diseases are thought to be associated with LP [3][4][5] . Psychological and emotional disorders are also thought to have a role 4 .…”

Section: Introductionmentioning

confidence: 99%

A case of erosive lichen planus with plantar involvement

Kılıç¹,

Baysak²,

Eşim³

et al. 2017

TURKDERM

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“…All 25 examined studies were randomized controlled trials; 22 of these were parallel group studies, 1 was a crosssectional study [21] and 2 were split-mouth design studies [11,12]. Furthermore, 4 were single-blind studies [14,19,24,25] and 9 were double-blind studies [10,16,[20][21][22][23][26][27][28]. Table 1 and Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Among all the studies, 7 compared active treatment with a placebo [10,20,21,23,28,29], and one of these studies compared placebos with multiple treatments [30]. A total of 14 clinical trials compared two different active treatments [11-13, 15-18, 22, 26, 27, 31-34]; 3 studies compared two different drugs belonging to the same class [19,26,27]; finally, one study compared two different routes of administration of the same drug [14].…”

Section: Methodsmentioning

confidence: 99%

“…It should be noted that some studies also excluded smokers [11][12][13] or heavy drinkers of alcohol [11] and patients with genital or skin lichenoid lesions [14][15][16][17][18], or patients affected by other types of oral lesions, different from those caused by OLP [19][20][21]. Finally, all trials using curcumin excluded patients with a history of gastric or duodenal ulcers, due to the irritative effect of turmeric on gastro-intestinal mucosa, and patients undergoing orthodontic treatment [22,23].…”

Section: Exclusion Criteriamentioning

confidence: 99%

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Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods:We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results:A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion:Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations. atrophic-erosive type, but are rarely present in reticular forms [3].It is important to distinguish OLP from oral lichenoid lesions, which can be similar in appearance, but the latter represent a reaction to specific causal factors (e.g. dental materials, traumas, drugs) [5].Managing OLP is aimed at reducing symptoms and the manifestation of lesions, characterized by periods of exacerbation and quiescence. The first-line treatment is represented by the use of topical corticosteroids, although other effective therapies, like photodynamic therapy and the use of calcineurin inhibitors have recently been made available. MATERIALS AND METHODSWe examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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Evaluation of the Efficacy of Curcumin in the Treatment of Oral Lichen Planus: A Randomized Controlled Trial

Cited by 33 publications

References 22 publications

A case of erosive lichen planus with plantar involvement

A case of erosive lichen planus with plantar involvement

Clinical Management of Oral Lichen Planus: A Systematic Review

Interventions for treating oral lichen planus: corticosteroid therapies

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