Evaluation of the effects of Bidens tripartita extracts and their main constituents on intestinal motility – An ex vivo study

Mendel, Marta; Chłopecka, Magdalena; Latek, Urszula; Karlik, Wojciech; Tomczykowa, Monika; Strawa, Jakub W.

doi:10.1016/j.jep.2020.112982

Cited by 12 publications

(12 citation statements)

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“…The combination of contraction and relaxation determines gut motility [24,25]. In presence of FGDIs, gut function is altered, and patients report a variety of symptoms, including motility disturbance, visceral hypersensitivity, altered mucosal and immune function, as well as changes in the gut microbiota [26][27][28]. The pathophysiology of FGIDs is still not fully understood, and various complex mechanisms appear to be implicated, mostly determining dysmotility [29,30].…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiology of FGIDs is still not fully understood, and various complex mechanisms appear to be implicated, mostly determining dysmotility [29,30]. In this regard, several plant formulations have been proposed as treatment options to improve the FGIDs by acting as a spasmolytic, carminative, or analgesic [5,28,31]. Accordingly, the effects of plant derivatives on GI activity should be thoroughly evaluated as a necessary step for determining the benefits of TtM use in FGIDs.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Tilia tomentosa Moench Extract on Mouse Small Intestine Neuromuscular Contractility

et al. 2021

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Functional gastrointestinal disorders (FGIDs) are characterized by abdominal pain, bloating and bowel disturbances. FGID therapy is primarily symptomatic, including treatment with herbal remedies. Flower extract of Tilia tomentosa Moench (TtM) is occasionally used as an anti-spasmodic in popular medicine. Since its effect on intestinal response is unknown, we evaluated the influence of TtM extract on small intestine contractility. Ileal preparations from C57BL/6J mice were mounted in organ baths to assess changes in muscle tension, following addition of TtM extract (0.5–36 μg/mL) or a vehicle (ethanol). Changes in contractile response to receptor- and non-receptor-mediated stimuli were assessed in ileal preparations pretreated with 12 μg/mL TtM. Alterations in the enteric nervous system neuroglial network were analyzed by confocal immunofluorescence. Increasing addition of TtM induced a marked relaxation in ileal specimens compared to the vehicle. Pretreatment with TtM affected cholinergic and tachykininergic neuromuscular contractions as well as K+-induced smooth muscle depolarization. Following incubation with TtM, a significant reduction in non-adrenergic non-cholinergic-mediated relaxation sensitive to Nω-Nitro-L-arginine methyl ester hydrochloride (pan-nitric oxide synthase inhibitor) was found. In vitro incubation of intestinal specimens with TtM did not affect the myenteric plexus neuroglial network. Our findings show that TtM-induced intestinal relaxation is mediated by nitric oxide pathways, providing a pharmacological basis for the use of TtM in FGIDs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Tilia tomentosa Moench Extract on Mouse Small Intestine Neuromuscular Contractility

et al. 2021

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“…Intestine preparations were incubated in modified Krebs-Henseleit solution under isometric conditions. The experiments included evaluating the effect of methanolic and 50% methanolic extracts of C. palustre on the spontaneous and acetylcholine(ACh)-induced contractility of colon smooth muscle 1 . An analytical approach based on LC-ESI-MS was applied to obtain a metabolite profile of analyzed extracts.…”

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Cirsium palustre extracts as potential modifiers of colon motility in functional gut disorders – an ex vivo study

et al. 2021

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“…Вся флора складається із флори природної (спонтанної) та культурної (похідної). Джерелом природних вітамінів можуть слугувати представники як природної, так і культурної флори (Zhohlo et al, 1992;Nechitaylo et al, 2005). Природна флора певних регіонів включає автохтонні та адвентивні види.…”

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“…Отже, автохтонні рослини природної флори є стародавнім, традиційним джерелом вітамінів. Як свідчать літературні відомості останніх п'яти років (Gusev et al, 2017;Rahimi-Madiseh et al, 2017;Santos et al, 2017;Pehlivan et al, 2018;Taşcı et al, 2019;Couto et al, 2020;Dhouibi et al, 2020;Kajszczak et al, 2020;Mendel et al, 2020), різнопланові дослідження вітаміноносних рослин залишаються актуальним питанням сучасності. Вітаміноносні рослини широко експонуються ex situ у ботанічних установах.…”

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Autochthonous vitamin-bearing plants of the Kiev Plateau

Gritsenko¹

2021

JNAPS

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Aim. To compile and analyze an annotated list of autochthonous vitamin-bearing plant species of the Kiev Plateau, which according to ethnobotanical traditions are often used by the population of this region. Methods. The research was carried out in 2002–2021 in natural phytocoenoses of the Kyiv Plateau and artificial phytocoenoses of M. M. Gryshko National Botanical Garden, National Academy of Sciences of Ukraine (NBG). Research methods are field and cameral. Dozens of locals were surveyed to find out which autochthonous vitamin-bearing plant species are most commonly used by the region's population. Latin names of plants are given according to the generally accepted taxonomy (Mosyakin & Fedoronchuk, 1999). A linear system (Golubev, 1972) was used for biomorphological analysis. The classification scheme of florocoenotypes (Kamelin, 1973) was used for ecologo-coenotic analysis. Results. An annotated list of autochthonous vitamin-bearing plant species of the Kyiv Plateau, which is frequently used by the population of the region, is given. The spectrum of families, biomorphological and ecologo-coenotic spectra, and priority of use of certain parts of plants are analyzed. Conclusions. The annotated list describes 43 species of plants belonging to 36 genera and 21 families. Rosaceae (26%) has the largest share in the spectrum of families. The biomorphological spectrum is dominated by herbaceous plants (61%), namely, herbaceous polycarpics (49%). In the ecologo-cenotic spectrum, the largest share is occupied by species of forest (42%) and meadow (33%) florocoenotypes. For practical use, the population of the region most often collects aboveground parts of plants, in particular, aboveground shoots (46%) or aboveground shoots and fruits (33%). All plant species listed in the annotated list are presented ex situ in the NBG. More than half of them (65.1%) are exhibited on the botanical-geographical plot “Steppes of Ukraine” of the NBG.

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Evaluation of the effects of Bidens tripartita extracts and their main constituents on intestinal motility – An ex vivo study

Cited by 12 publications

References 38 publications

Influence of Tilia tomentosa Moench Extract on Mouse Small Intestine Neuromuscular Contractility

Influence of Tilia tomentosa Moench Extract on Mouse Small Intestine Neuromuscular Contractility

Cirsium palustre extracts as potential modifiers of colon motility in functional gut disorders – an ex vivo study

Autochthonous vitamin-bearing plants of the Kiev Plateau

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