Evaluation of the effects of intra-arterial sugammadex and dexmedetomidine: an experimental study

Abstract

Administration of sugammadex and dexmedetomidine to rabbits by intra-arterial routes caused histological arterial damage. To understand the histological changes caused by sugammadex and dexmedetomidine more clearly, more experimental research is needed.

The incidence, significance, and management of accidental intra-arterial injection: a narrative review

“…An experimental animal study involving sugammadex is included. 37 The presentation, time sequence, and complications of injuries caused by illicit intra-arterial injections and iatrogenic injuries suggest a similar pathophysiology and it may be possible to extrapolate the evaluation of injury severity and treatment options derived from one group to the other.…”

Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model

“…In this study, while no histopathological effect was observed in the control group and low-dose (2 mg/kg) sugammadex group, the necrotic changes observed in the high-dose (16 mg/kg) group lead us to consider that the effect is linked to the dose used. In a previous study, Hanci et al (20) administered sugammadex intraarterially at a dose of 4 mg/kg in rabbits and they reported signifi cant histopathological changes in arterial endothelial structure due to endothelial damage compared to the control group. Hence, we decided to investigate the effects of sugammadex doses of 2 mg/kg and 16 mg/kg to create a dose-response curve.…”