Evaluation of the effect of transplant-related factors and tissue injury on donor-derived hepatocyte and gastrointestinal epithelial cell repopulation following hematopoietic cell transplantation

The Effect of Graft-Versus-Host Disease on Skin Endothelial and Epithelial Cell Chimerism in Stem-Cell Transplant Recipients

“…Furthermore, the presence of epithelial cell chimerism did not seem to depend on the tissue damage induced by acute or chronic GVHD. This was also described in two studies on donor-derived hepatocytes and epithelial cells in the gastrointestinal tract after SCT (17,18). A few other studies found an effect of acute GVHD on the occurrence of epithelial cell chimerism.…”

“…In addition, graft-derived cells with an epithelial phenotype have been described in skin (10), gastrointestinal tract, and liver (17,18) of human hematopoietic stem-cell transplant recipients. However, the exact origin of these cells and their pattern of engraftment in response to injury remain elusive (17).…”

“…However, the exact origin of these cells and their pattern of engraftment in response to injury remain elusive (17).…”

The fate of recipient‐derived hepatocytes in sex‐mismatched liver allograft following liver transplantation

“…To sustain homeostasis, stem cells regulate the rate of cell production by increasing the function of cells undergoing cellular proliferation and maturation in response to tissue injury (1–15). Previous studies have reported that the bone marrow (BM)‐derived stem cells were shown to engraft and populate non‐hematopoietic tissues during tissue injury in transplants (1–15). This cellular plasticity varied from 0% to 40% of the tissue (1–15).…”

“…Previous studies have reported that the bone marrow (BM)‐derived stem cells were shown to engraft and populate non‐hematopoietic tissues during tissue injury in transplants (1–15). This cellular plasticity varied from 0% to 40% of the tissue (1–15). It has also been reported that BM cells might help restore some forms of hepatic diseases (7, 14, 15).…”