Evaluation of the effect of ethanolic extract of Croton zambesicus on the testes of Swiss albino mice

Abstract

The possible effect of Croton zambesicus administration on vital organs has been less investigated despite its extensive traditional use in tropical Africa. We therefore aim at elucidating the effect of ethanolic extract on the testes. The aqueous fraction of ethanolic leaf extract of C. zambesicus (5 and 10 mg/Kg body weight) was administered to verify its effect on sperm concentration, sperm motility, sperm progessivity, malondialdehyde and catalase activities for a period of five consecutive days. The result showed that there is a significant increase in sperm production, sperm motility and sperm progressivity in the treated group when compared with the control; while there was a reduction in malondialdehyde and catalase activity in all the treated groups. The slight increase in the weight of the measured parameters also indicated the positive effect of the extract in the normal metabolic activities in the treated groups. This investigation has shown that the leaf extract possesses promising profertility property which can be exploited in fertility therapy.

The microstructural effects of aqueous extract of Garcinia kola (Linn) on the hippocampus and cerebellum of malnourished mice

“…These two types differ morphologically and biochemically [8][9][10][11] . Accidental cell death is regarded as necrotic and could result from extrinsic insults to the cell such as osmotic, thermal, toxic and traumatic effects [11][12][13] . Pathological cell death is regarded as apoptotic and is an organized programmed cell death (PCD) that is mediated by active and intrinsic mechanism.…”

“…G. kola seeds contain biflavonoid possessing antiinflammatory properties [4] and are a natural antioxidant [1][2][3][4] . Constituents of the seed of G. kola include [1][2][3][8][9][10][11] benzophenones, Garcinia biflavonones (GB-1, GB-2) and kola flavonone [2,3] . Apigenin based flavonoids represent 60% of the total flavonoids present in the diethyl ether fraction of G. kola seed [4] .…”

Medicinal plants as potential male anti-infertility agents: a review

“…From the above paragraphs, many beneficial effects of medicinal plants on male reproductive function are associated with antioxidant effects [35,37,56,61,73]. This suggests that the potential of phytomedicines to improve male fertility is due to presence of antioxidants.…”

“…Administration of the ethanol extract of Croton zambesicus at the dose of 5 and 10 mg/kg in vivo increased the sperm number and motility, but decreased malonic aldehyde levels and catalase activity in healthy mice after five days of treatment [56]. Korean ginseng (P. ginseng) administered at the dose of 1 g/kg for 56 days in male rats increased sperm count and motility, testis cAMP-responsive element modulator (CREM) mRNA and CREM protein [57].…”

Effect of Diet Contains Sesame Seed on Epididymal Histology of Adult Rat

“…Also, ethanolic extract of sesame enhances morphology of the spermatozoa in the epididymis at the time of sacrifice of the animals (Saalu et al, 2007b Ofusori et al (2007) evaluated the effect of ethanolic extract of croton zambesicus (as a potent antioxidant and free radical scavenger) on the testes of swiss albino mice and reported that there was a significant increase in the sperm concentration, motility, and progressivity in the treated group rather than the control group. This significant increase was observed to be dose dependent C. zambesicus.…”