Evaluation of the durability and antiadhesive action of 2-methacryloyloxyethyl phosphorylcholine grafting on an acrylic resin denture base material

Takahashi, Nana; Iwasa, Fuminori; Inoue, Yasuo; Morisaki, Hirobumi; Ishihara, Kazuhíko; Baba, Kazuyoshi

doi:10.1016/j.prosdent.2013.08.020

Cited by 52 publications

(61 citation statements)

References 17 publications

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“…Therefore, we hypothesized that zwitterionic polymer grafted layers would attract water molecules only and repel positively charged inorganic ions and negatively charged protein molecules and bacteria cells. Several previous studies have reported that the water molecules adsorbed on the surface of MPC polymers, e.g., poly(MPC-co-n-butyl methacrylate) (PMB) or PMPC, act as an antibiofouling layer to reduce the interaction between the surface and living organism [39,[43][44][45][46]. Fujii et al [43] and Takahashi et al [44] reported that PMB-coated and PMPC-grafted metal or polymer surfaces reduced bacteria adhesion.…”

Section: Discussionmentioning

confidence: 99%

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer

et al. 2015

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“…43,44,47 Each disk was immersed in phosphate buffered saline (PBS) for 2 h before immersing in 4.5 g/L bovine serum albumin (BSA) (Sigma-Aldrich) solutions at 37 °C for 2 h. 43,44 The disks then were rinsed with fresh PBS by stirring method (300 rpm for 5 min). The adsorbed protein was detached in sodium dodecyl sulfate (SDS) 1 wt% in PBS by sonication for 20 min.…”

Section: Methodsmentioning

confidence: 99%

“…45,46 Previous study evaluated the durability and antiadhesive action of MPC grafting on an acrylic resin denture base material. 47 The results demonstrated that graft polymerization of MPC on denture surfaces contributed to the durability of the coating and prevented microbial retention. However, there has been no report on the application of MPC to the dentin bonding agents.…”

Section: Introductionmentioning

confidence: 94%

Novel protein-repellent dental adhesive containing 2-methacryloyloxyethyl phosphorylcholine

Zhang

Melo

Bai

et al. 2014

Journal of Dentistry

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Objectives Biofilms at tooth-restoration margins can produce acids and cause secondary caries. A protein-repellent adhesive resin can potentially inhibition bacteria attachment and biofilm growth. However, there has been no report on protein-repellent dental resins. The objectives of this study were to develop a protein-repellent bonding agent incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC), and to investigate its resistance to protein adsorption and biofilm growth for the first time. Methods MPC was incorporated into Scotchbond Multi-Purpose (SBMP) at 0%, 3.75%, 7.5%, 11.25%, and 15% by mass. Extracted human teeth were used to measure dentin shear bond strengths. Protein adsorption onto resins was determined by a micro bicinchoninic acid (BCA) method. A dental plaque microcosm biofilm model with human saliva as inoculum was used to measure biofilm metabolic activity and colony-forming unit (CFU) counts. Results Adding 7.5% MPC into primer and adhesive did not decrease the dentin bond strength, compared to control (p > 0.1). Incorporation of 7.5% of MPC achieved the lowest protein adsorption, which was 20-fold less than that of control. Incorporation of 7.5% of MPC greatly reduced bacterial adhesion, yielding biofilm total microorganism, total streptococci, and mutans streptococci CFU that were an order of magnitude less than control. Conclusions A protein-repellent dental adhesive resin was developed for the first time. Incorporation of MPC into primer and adhesive at 7.5% by mass greatly reduced the protein adsorption and bacterial adhesion, without compromising the dentin bond strength. The novel protein-repellent primer and adhesive are promising to inhibit biofilm formation and acid production, to protect the tooth-restoration margins and prevent secondary caries.

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“…And our previous research confirmed that both ABWs and ZrO2 were added in PMMA with certain proportion, the results showed that they could improve the mechanical properties obviously 10,11) . Another clinical problem associated with self-curing acrylic resins is the adhesion of dental plaque formed by oral microorganisms due to the PMMA's high water absorption capacity, surface porosities and materia alba configuration 13) . Denture plaque is a source of infection and is responsible for a variety of clinical problems, including abutment caries, denture stomatitis and aspiration pneumonia 14) .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity, cytotoxicity and mechanical behavior of nano-enhanced denture base resin with different kinds of inorganic antibacterial agents

Chen

Han

Huang

et al. 2017

Dental Materials Journal

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Silanized aluminum borate whiskers (ABWs) of 4 wt%, silanized zirconium dioxide nanoparticles (nano-ZrO2) of 2 wt% were mixed with polymethyl methacrylate (PMMA) powder to get ZrO2-ABWs/PMMA composites. Titanium dioxide (TiO2), silver-supported titanium dioxide (Ag/TiO2), silver-supported zirconium phosphate (Novaron) and tetrapod-like zinc oxide whiskers (T-ZnOw) antibacterial agents of 3 wt% were mixed with ZrO2-ABWs/PMMA composites respectively to fabricate standard specimens. Plaque biofilms on the specimens surface were investigated for colony-forming units (CFUs). In addition, cytotoxicity and mechanical behavior were evaluated. Results showed that the CFUs values of S. mutans and C. albican biofilms on the four antibacterial composites surface were all reduced (p<0.05) compared to the blank and control groups. The antibacterial composites did not have an adverse effect on fibroblast growth in this study (p>0.05) except TiO2 and Ag/TiO2 groups of undiluted extracts. The flexural strength and surface hardness of Novaron and T-ZnOw groups were increased (p<0.05) compared to the control group.

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Evaluation of the durability and antiadhesive action of 2-methacryloyloxyethyl phosphorylcholine grafting on an acrylic resin denture base material

Cited by 52 publications

References 17 publications

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer

Novel protein-repellent dental adhesive containing 2-methacryloyloxyethyl phosphorylcholine

Antibacterial activity, cytotoxicity and mechanical behavior of nano-enhanced denture base resin with different kinds of inorganic antibacterial agents

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