Evaluation of the Corticosteroid Receptors’ Level in the Kidneys of Rats After Systemic Ischemia-Reperfusion

Abstract

Background: With disturbance of the systemic blood supply, the body experiences hypoxia and stress. Under stress of any etiology, there is a non-specific rearrangement of physiological and biochemical processes. These processes occur under the influence of corticosteroid hormones. Aim: To determine the level of corticosteroid receptors in the kidneys of rats at different times after systemic ischemia-reperfusion. Methods: The study included 80 male white rats. All the animals were divided into 2 groups. A model of systemic ischemia-reperfusion was created in the main group (n=70). Further, on 1, 3, 5, 7, 14, 21 and for 35 days, we determined the level of gluco - and mineralocorticoid receptors in the kidneys. Results: In the animals of the main group, we observed a short-term period (during the first 3 days) of a decrease in the content of both glucorticoid (p<0.05) and mineralocorticoid (p<0.01) receptors. The dynamics of recovery of the level of corticosteroid receptors was 3 times faster than that of mineralocorticoid receptors. Conclusions: The dynamics of corticosteroid receptors’ level in the kidneys of rats after ischemia caused by an arrest of systemic circulation show the recovery time after ischemia-reperfusion injury, which ensures the stability of an individual to hypoxia.