Evaluation of the clinical value of hematological parameters in patients with urothelial carcinoma of the bladder

Abstract

This study aimed to evaluate the clinical significance of pretreatment red cell distribution width (RDW), monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) in patients with urothelial carcinoma of the bladder (UCB).Hematological parameters of 127 consecutive patients with UCB and 162 healthy controls were retrospectively analyzed. Receiver operating characteristic curve was plotted to determine the optimal cut-off value of RDW, MLR, NLR, and PLR to predict UCB. Whether these parameters could be independent predictors of UCB and had an association with the demographics and clinical characteristics of patients were also assessed.Patients with UCB had higher pretreatment RDW, MLR, NLR, and PLR compared with the healthy controls. With the tumor progression, MLR, NLR, and PLR rose consistently, whereas no significant difference was observed in RDW across tumor stages. NLR and PLR were associated with tumor size and tumor grade, while MLR was correlated with tumor size only. The best threshold of RDW, MLR, NLR, and PLR to predict UCB was 13.50%, 0.26, 2.16, and 128.46, respectively. Multivariate logistic regression model identified NLR ≥ 2.16 (odds ratio [OR] = 2.914; P < .001) and PLR ≥ 128.46 (OR = 2.761; P < .001) as independent predictors of UCB. High NLR and PLR were also associated with tumor markers, such as carcinoembryonic antigen and α-fetoprotein.Pretreatment NLR and PLR could be significant independent predictors of UCB. These simple and readily available inflammatory markers therefore might be used to manage the disease.

Development and Validation of a Novel Recurrence Risk Stratification for Initial Non-Muscle Invasive Bladder Cancer in the Han Chinese Population

“…However, there is no new consensus indicator on the risk factors for the recurrence of NMIBC, especially the lack of relevant tumor indicators in urine. Urine BLCA-4, BTA, NMP22, and CEA can be used as important markers for the diagnosis and recurrence monitoring of bladder cancer [23][24][25][26][27][28][29][30]. At present, the specificity and sensitivity of BLCA-4 detection for bladder cancer diagnosis have reached a high level.…”

“…CEA is a tumor-associated antigen. There is no CEA in normal urinary tract, but the urinary CEA in bladder cancer patients is significantly increased [30]. In this study, we also included the above four urine markers to establish a recurrence risk model.…”

Prognostic Significance of Preoperative Systemic Cellular Inflammatory Markers in Gliomas: A Systematic Review and Meta‐Analysis

“…The increase in the neutrophil count may cause a decrease in lymphocytes and lymphocyte apoptosis . This interaction between neutrophils and lymphocytes in response to inflammation is of significance in immunosuppression . Secretion of Arginase‐1 by neutrophil supports immunosuppression and VEGF‐A production induces angiogenesis .…”

“…23 This interaction between neutrophils and lymphocytes in response to inflammation is of significance in immunosuppression. 20,23,40 Secretion of Arginase-1 by neutrophil supports immunosuppression and VEGF-A production induces angiogenesis. 29,37 Neutrophils also promote angiogenesis by inducing a shift of gliomas from the proneural to the mesenchymal subtype, contributing to anti-angiogenic therapy resistance.…”

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma

“…Elevated RDW is more frequent in malignant biliary obstruction than benign cases, pointing to a diagnostic role of RDW in cases of biliary obstruction . Patients with urothelial carcinoma of the bladder (UCB) have elevated RDW compared with healthy individuals, suggesting RDW could be used in the diagnosis of UCB . Elevated RDW also helps identify colorectal cancer, ovary cancer, and myelodysplastic syndromes …”