Evaluation of the clinical Index of Stable febrile neutropenia risk stratification system for management of febrile neutropenia in gynecologic oncology patients

Abstract

Highlights The CISNE score is able to accurately identify a cohort of gynecologic oncology patients with low-risk febrile neutropenia. The CISNE performs similarly to the MASCC score when low-risk and intermediate-risk patients are grouped together. Lowering the CISNE threshold for low-risk febrile neutropenia may be a safer method of caring for gynecologic patients. Using the MASCC followed by CISNE with the lower threshold yielded the most favorable performance characteristics.

Management of chemotherapy-induced febrile neutropenia and use of granulocyte colony-stimulating factor in patients with soft tissue or bone sarcoma

“…20 Previous exposure to radiotherapy, identified in 24.13% of FN events, is consistent with the findings of Monuszko et al who demonstrated that 24% of patients who developed FN had received radiation along with chemotherapy. 6 In a study conducted in the United States, the number of hospitalizations for cancer-related neutropenia was 5.2%, and the length of hospitalization was 0 to 7 days. 21 In the present study, approximately 55% of the patients were hospitalized for 5 to 9 days, and those who remained for more than 20 days (6.89%) had associated comorbidities and died.…”

“…Previous exposure to radiotherapy, identified in 24.13% of FN events, is consistent with the findings of Monuszko et al who demonstrated that 24% of patients who developed FN had received radiation along with chemotherapy. 6…”

“…The period of hospitalization associated with FN can vary from 5 to 10 days, leading to unfavorable clinical outcomes, increased morbidity, mortality, and hospital costs. [6][7][8][9] The use of an instrument that stratifies patients according to the risk of developing complications resulting from FN, such as the Multinational Association of Supportive Care in Cancer (MASCC) is important to define prevention measures based on risk factors (comorbidities, age, type of tumor, staging, hypotension, and performance status). 8,10 FN patients have a 50% more chance of infections, of which 20% may progress to bacteremia.…”

“…The period of hospitalization associated with FN can vary from 5 to 10 days, leading to unfavorable clinical outcomes, increased morbidity, mortality, and hospital costs. 6–9…”