Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha

A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner

“…Since thousands of years, this medicine has been used for treating cancer, cuts, dermatitis, measles, macular eruptions, sore-throats, carbuncles and burns (Duke and Ayensu, 1985;Yuan, 1977). It is officially listed in the Chinese Pharmacopoeia with similar indications and in the last couple of years, extracts and isolated compounds of these plants were shown to possess anti-inflammatory (Hayashi, 1977;Kundakovic et al, 2006), antitumorigenic (Chen et al, 2002), wound healing, antimicrobial, antithrombotic (Papageorgiou et al, 1999) and antifungal (Sasaki et al, 2002) activities. However, whereas different extracts of Arnebia and Lithospermum species are already well characterized, Onosma paniculatum is hardly investigated towards its anticancer activity.…”

Evaluation of anti-inflammatory and antinociceptive activities of some Onosma L. species growing in Turkey

“…root which is the most active fraction for carrageenan-induced rat paw edema test. The extracts and isolated components also exerted cytotoxic activity on both L1210 murine lymphoblastic leukemia cell lines and human fibrosarcoma HT-1080 cells (Kundakovic et al, 2006). The n-hexane-dichloromethane extract from the roots of Onosma argentatum Hub.-Mor.…”

“…(El-Shazly et al, 2003), Onosma leptantha Heldr. (Kundakovic et al, 2006) and Onosma stellatum W.K. (Mroczek et al, 2004), lipids from Onosma heterophylla Griseb (Mellidis and Papageorgiou, 1987;Papageorgiou and Assimopoulou, 2003), ketones and triterpenoids from Onosma limitaneum I.M.…”

The anti-proliferation effect of Aikete injection on hepatocellular carcinoma in vitro and in vivo

“…Aikete injection is composed of acetylshikonin and β,β-dimethylacrylshikonin (Figure 1), the two main effective anti-tumor components of shikonin (Hu et al, 2006;Kundakovic et al, 2006;Zeng et al, 2009). Although the anti-tumor effect of acetylshikonin and β,β-dimethylacrylshikonin has been reported widely, little is known about the effects of the combination of the two components on cancer cells.…”