Evaluation of the anti-diabetic effect of biogenic silver nanoparticles and intervention in PPARγ gene regulation

Manimegalai, S.; Bavithra, V; Banerjee, Manosi; Choudhury, Abbas Allam; Chakraborty, Shreya; Ramasubbu, Kanagavalli; Rajeswari, Devi; Obaid, Sami Al; Alharbi, Sulaiman Ali; Subramani, Baskaran; Brindhadevi, Kathirvel

doi:10.1016/j.envres.2022.114408

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…We designed a substantiated release mechanism for Linum usitatissimum triple gel containing CMC and carbopol. Brown flax seeds are known for its nutritional and medicinal values and moreover it is known for reducing the inflammatory reactions in hypertension patients and cardiac patients [ 20 , 21 ]. A brown flax seed also maintain lipid profile and is rich in dietary fibers which are other form of vitamin E, thereby capable of binding with free radicals and executing standard anti-oxidant properties [ 22 ][ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore the combination of brown flax seed extract, carboxy methyl cellulose and carbopol were prepared into a herbal trio gel. Herbal interventions are known for its nutritional and medicinal values [ 20 ]. Therefore goal of this research was to formulate a triple gel for local drug administration and evaluate its antimicrobial and anti-inflammatory activities, as well as quality analysis using SEM and FTIR.…”

Section: Discussionmentioning

confidence: 99%

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Formulation and evaluation of a novel herbal trio gel containing flax seed extract, carbopol and carboxymethyl cellulose

Shanmugam

2023

Bioinformation

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It is of interest to formulate and evaluate herbal trio gel containing brown flax seed extract, carbopol, and carboxymethyl cellulose and to assess the antimicrobial, anti-inflammatory activity along with quality analysis using SEM and FTIR. The brown flax seeds were grinded into a fine powder and supercritical fluid was prepared which was mixed with CMC and carbopol. The formulation was checked for antimicrobial, anti-inflammatory activity, surface characteristics with SEM and FTIR. The results revealed that the antimicrobial activity of the trio gel was efficacious in hampering the growth of black pigmented anaerobes. The highest zone of inhibition for novel herbal trio gel was recorded at 100 μL measuring 14mm and for the standard chlorhexidine gel it was recorded at 100 μL measuring 23mm in diameter. The results proved that the zone of inhibition of novel herbal trio gel had a decent difference to that of standard chlorhexidine gel. The anti-inflammatory activity showed significant activity at 20 μL which accounted for 53% for the novel herbal trio gel and for the standard diclofenac gel it showed highest activity at 20 μL which accounted for 60%. However, there was not much difference between the herbal trio gel and standard diclofenac gel. SEM observations revealed that the components used in formulation of this trio gel have been bonded well to each other and exhibited appreciable surface characteristics. The lattice of the trio gel has been very well exhibited in SEM analysis. FTIR revealed high peaks showing the different components present in the trio gel. Within the limitations of the study, the results of our study concluded that novel herbal trio gel containing Linum usitatissimum extract, sorbitol, and carboxymethyl cellulose could be an efficient economic primeval substitute that is non-toxic, natural, and structured for clinical application.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Formulation and evaluation of a novel herbal trio gel containing flax seed extract, carbopol and carboxymethyl cellulose

Shanmugam

2023

Bioinformation

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“…These features of AgNPs aid in their wide biomedical applications as antioxidant, anti-inflammatory, antimicrobial, anticancer, and antidiabetic agents. The pathology of all of these is related to oxidative injury [216][217][218][219]. The synthesis of AgNPs from Tamarix articulata leaf extract showed potential anti-inflammatory and antimicrobial activity.…”

Section: Protective Effect Of Silver-based Nps (Agnps) and Their Anti...mentioning

confidence: 99%

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Patel,

Kevadiya,

Bajwa

et al. 2023

Antioxidants

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Oxidative stress is a deteriorating condition that arises due to an imbalance between the reactive oxygen species and the antioxidant system or defense of the body. The key reasons for the development of such conditions are malfunctioning of various cell organelles, such as mitochondria, endoplasmic reticulum, and Golgi complex, as well as physical and mental disturbances. The nervous system has a relatively high utilization of oxygen, thus making it particularly vulnerable to oxidative stress, which eventually leads to neuronal atrophy and death. This advances the development of neuroinflammation and neurodegeneration-associated disorders such as Alzheimer’s disease, Parkinson’s disease, epilepsy, dementia, and other memory disorders. It is imperative to treat such conditions as early as possible before they worsen and progress to irreversible damage. Oxidative damage can be negated by two mechanisms: improving the cellular defense system or providing exogenous antioxidants. Natural antioxidants can normally handle such oxidative stress, but they have limited efficacy. The valuable features of nanoparticles and/or nanomaterials, in combination with antioxidant features, offer innovative nanotheranostic tools as potential therapeutic modalities. Hence, this review aims to represent novel therapeutic approaches like utilizing nanoparticles with antioxidant properties and nanotheranostics as delivery systems for potential therapeutic applications in various neuroinflammation- and neurodegeneration-associated disease conditions.

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Pancreatic β cell models for screening insulin secretagogues and cytotoxicity

Potdar,

Kharat,

Sanap

et al. 2024

J of Applied Toxicology

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In the past 2–3 decades, numerous attempts have been made to create an insulin‐secreting β cell line that maintains normal insulin secretion. However, primary β cell cultures have finite life and, therefore, cannot be used for long‐term experiments. The most widely used insulin‐secreting cell lines are Insulinoma‐1, rat insulinoma cell line, hamster pancreatic β cell line, mouse insulinoma, and β tumor cell line. Insulinoma‐derived cell lines show infinite growth in tissue culture but exhibit varying differences in their insulin responsiveness to glucose levels compared to normal β cells. Despite difficulties with β cell cultures, these cell lines have offered some useful insights in diabetes research concerning physiological functions and pathological investigations. In this review, we describe insulinoma cell lines used for drug screening, insulin secretion, cell viability, proliferation, and other relevant cellular functions. In addition, we have also incorporated recently developed human β cell lines. These cell lines have provided some helpful insights into physiological activities and pathology in diabetes research, despite challenges with β cell culturing. We propose that these cell lines could also be explored for screening Ayurvedic Rasayanas and homeopathy preparations for their cytotoxicity and insulin secretagogue activities to have evidence‐based data on alternative and complementary medicines.

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Evaluation of the anti-diabetic effect of biogenic silver nanoparticles and intervention in PPARγ gene regulation

Cited by 8 publications

References 38 publications

Formulation and evaluation of a novel herbal trio gel containing flax seed extract, carbopol and carboxymethyl cellulose

Formulation and evaluation of a novel herbal trio gel containing flax seed extract, carbopol and carboxymethyl cellulose

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

Pancreatic β cell models for screening insulin secretagogues and cytotoxicity

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