“…Most of the studies investigated microstructural metrics at whole brain level. Nine studies focused on specific pathways as regions of interest: optic radiation (OR) (Rocca et al, 2008 ), corticospinal tract (CST) (Rocca et al, 2008 ), corpus callosum (CC) (Li et al, 2011 ; Rocca et al, 2008 ), red nuclei, PAG, thalami, posterior limbs of IC (PLICs), subcortical WM (Kara et al, 2013 ), thalamus (Coppola et al, 2016a , b ; Coppola et al, 2014 ), cerebellum and brainstem (Qin et al, 2019 ), anterior insula, cingulate gyrus, uncinate fasciculus (Gomez-Beldarrain et al, 2015 ), and orbitofrontal cortex (Tantik Pak et al, 2021 ). Table 2 summarizes the imaging methodologies of the included studies.…”