Evaluation of Simvastatin Efficacy on Bone Regeneration for Socket Preservation

Abstract

Objective of this study to was to evaluate the efficacy of simvastatin on bone regeneration for socket preservation after tooth extraction radiographically. Subject & Methods: 20 dental sockets were classified equally in to two groups. Group A: (study group), where 10 tooth sockets were filled gelatin sponge with simvastatin. Group B: (control group), where 10 tooth sockets were filled with gelatin sponge alone. all sockets were then closed with black silk Follow up patients to assess pain , swelling or presence of infection Computed tomographic (CBCT) scanning was performed immediately and after four months to measure the bone height, bone width, and bone density The radiographic measurements were compared and the differences were statistically analyzed. Results: It was found significant increase in density in the study group than the control group, there was a statistically significant difference in mean width in the two groups and there was a statistically non-significant difference in mean height in the two groups. Conclusion: Simvastatin induce bone formation as in this study showing a significant increase in density in the simvastatin group than the control. But cannot preserve alveolar bone height