Evaluation of serum osteoprotegerin and fetuin A levels in Egyptian patients with chronic kidney disease

Nessim, Iris; Wahab, Amal Abd el; Madani, Hanan; Waked, Emam; Khalek, Ashraf Abd el; Mabrouk, Khaled

doi:10.1007/s00580-011-1281-9

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…According to Delmas et al [ 47 ], raised levels of circulating osteocalcin in patients with mild or moderate renal impairment reflect enhanced bone metabolism rather than decreased renal filtration. In this study, fetuin A level decreased significantly with the progression of CKD, which is consistent with the results of other studies [ 50 , 51 ]. Schafer et al [ 52 ] suggested that fetuin A deficiency in haemodialysis patients may be responsible for the development of calciphylaxis, which includes changes in small arterioles.…”

Section: Discussionsupporting

confidence: 93%

Markers of increased cardiovascular risk in patients with chronic kidney disease

et al. 2014

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BackgroundEpidemiological studies have shown that chronic kidney disease (CKD) is an important risk factor for atherosclerosis and cardiovascular disease (CAD). The aim of the study was to determine markers of increased risk of CAD and to achieve a better understanding of agents implicated in the process of atherosclerosis in CKD patients.MethodsThe study group consisted of a total of 139 patients with CKD while the control group comprised 45 healthy volunteers. Concentrations of osteoprotegerin, osteopontin, osteocalcin, matrix γ-carboxyglutamic acid (Gla) protein (MGP), fetuin A, matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), tissue inhibitor of metalloproteinase-2 (TIMP-2), ATP binding cassette transporter A1 (ABCA1), ATP binding cassette transporter G1 (ABCG1) and renalase were measured by the ELISA method.ResultsWe observed decreased levels of fetuin A (control vs. CKD group: 37.5 vs. 33.2 ng/ml, p = 0.018), and increased concentrations of osteocalcin (control vs. CKD group: 9.1 ± 6.0 vs. 13.6 ± 10.3 ng/ml, p = 0.05), MMP-2 (113.1 ± 75.0 vs. 166.0 ± 129.9 ng/ml, p = 0.045), TIMP-2 (22.1 ± 5.1 vs. 25.4 ± 7,0 ng/ml, p = 0.005) and renalase (251.0 ± 157 vs. 316.1 ± 155.3 ng/ml, p = 0.026). In patients with CKD (in comparison to control group), left ventricle ejection fraction: 53.0 ± 3,5% vs. 48.5%, p = 0.012) and calcification of the aortic valve (9.5% vs. 39.8%, p = 0.008) were observed more frequently.ConclusionsDecreased levels of fetuin A and increased concentration of osteocalcin, renalase, MMP-2 and TIMP-2 suggest that these factors may be involved in the pathogenesis of CAD in patients with CKD. Significantly increased indices of cardiac hypertrophy and its dysfunction in patients with CKD are indicators of pathological mechanisms occurring in cardiovascular system in this group of patients.

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Section: Discussionsupporting

confidence: 93%

Markers of increased cardiovascular risk in patients with chronic kidney disease

et al. 2014

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“…Fetuin-A showed an inverse correlation with dialysis vintage, time-averaged serum phosphate and hs-CRP [ 19 ]. Few studies in adult revealed that fetuin-A levels were significantly lower in the CKD group compared to the controls and no correlation between GFR and serum fetuin-A [ 7 , 20 , 21 ]. In Kayser et al study, serum fetuin-A concentrations were found to be decreased in all adult CKD patients but stage 1 CKD [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Fetuin-A and Ghrelin Levels in Children with End Stage Renal Disease and the Effect of a Single Hemodialysis Session on Them

Shouman

Ismail

Badr

et al. 2015

Open Access Maced J Med Sci

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BACKGROUND:Fetuin-A and ghrelin have been implicated in cardiovascular diseases and mortality among end stage renal disease patients. The exact mechanisms have not been fully elucidated. There is robust data supporting an association between ghrelin and various cardiovascular conditions, and some common processes such as inflammation, oxidative stress, and endoplasmic reticulum stress have been implicated.AIM:This study was conducted to assay serum fetuin-A and ghrelin in chronic renal failure pediatric patients and to study changes in their level that may occur after a single hemodialysis.MATERIAL AND METHODS:Forty nine pediatric patients suffering from ESRD on maintenance hemodialysis (HD), 20 patients with chronic renal failure (CRF) not on dialysis and 35 healthy subjects as control group were included. The mean age of the study population was 10.58 ± 3.94, 10.62 ± 3.24 and 10.61 ± 3.97 years respectively. Serum fetuin-A and plasma acyl ghrelin levels were measured by using ELISA method.RESULTS:The present study revealed that predialysis serum fetuin-A level was significantly increased in pediatric HD patients compared with the normal population, while ghrelin levels were significantly reduced. Furthermore, serum levels of fetuin-A decreased significantly after a single HD session.CONCLUSION:Our study concluded that fetuin-A and acyl ghrelin may play a role in inflammatory process among HD pediatric patients which may account for cardiovascular insults and mortality but their use as biochemical markers among ESRD pediatric patients have limitations due to wide fluctuations.

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Evaluation of serum osteoprotegerin and fetuin A levels in Egyptian patients with chronic kidney disease

Cited by 2 publications

References 26 publications

Markers of increased cardiovascular risk in patients with chronic kidney disease

Markers of increased cardiovascular risk in patients with chronic kidney disease

Fetuin-A and Ghrelin Levels in Children with End Stage Renal Disease and the Effect of a Single Hemodialysis Session on Them

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