Evaluation of serum lipoprotein (a) in young patients with myocardial infarction

Kamariya, Chandrakant P.; Gorasia, Jignesh H.; Vachhani, Uday; Gohel, Mukesh C.

doi:10.4103/2230-8598.127169

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…High levels of TG (more than 150 mg/dl) were found in 37 % patients [mean ± SD (145.28 mg/dl ± 65.78)]. Our results were in agreement with that of Kamariya et al, [17] and Yadav and Bhagwat who reported increased TC, TG, LDL and decreased HDL levels in patients with ACS.…”

Section: % 33% 24%supporting

confidence: 92%

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Patange¹,

Immadisetty²,

Vora³

et al. 2020

jemds

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BACKGROUND Coronary artery disease (CAD) is the leading cause of mortality in men and women. Acute coronary syndrome (ACS), is a major reason for hospitalisation in our country. Dyslipidemia has been identified as one of the most important modifiable risk factors for CAD. The aim of the study was to determine the prevalence and pattern of dyslipidaemia and its relation to other modifiable risk factors. METHODS 100 cases were studied in a Krishna Institutes of Medical Sciences, Karad, over a period of 12 months from 1 st August 2015 to 31 st July 2016. This is a prospective observational study. All adults >18 years of age admitted for acute coronary syndrome were eligible for this study. The ACS group was studied as STEMI, NSTEMI, and Unstable Angina. RESULTS Majority of patients (33) was in the age group 51-60 years followed by 29 patients in the age group 61-70 years. Out of 100 ACS patients, 62 were STEMI, 20 were NSTEMI, and 18 were unstable angina. The prevalence of ACS was higher in males than females. Hypertension is the most common risk factor of ACS (41%) followed by diabetes mellitus (33%). We found that high levels of TC (more than 200 mg/dl) were found in 31% patients [mean ± SD (167.79 mg/dl ± 45.28)]. High levels of LDL (more than 130 mg/dl) were found in 23% patients [mean ± SD (97.47 mg/dl ± 38.24)]. Low levels of HDL (less than 40 mg/dl) were found in 52% patients [mean ± SD (40.69 mg/dl ± 11.84)]. High levels of TG (more than 150 mg/dl) were found in 37 % patients [mean ± SD (145.28 mg/dl ± 65.78)]. CONCLUSIONS Dyslipidemia is one of the major risk factors which is widely prevalent in patients with ACS and is more prevalent in males than in females. We recommend paying more attention to serum lipids and other modifiable risk factors for prevention of ACS

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Section: % 33% 24%supporting

confidence: 92%

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Patange¹,

Immadisetty²,

Vora³

et al. 2020

jemds

View full text Add to dashboard Cite

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“…In our study, patients admitted with CAD showed a significant increase in TG attributable to the ongoing inflammatory process, hepatic synthesis and lipolysis at the time of illness. In a study conducted by Kamariya et al, 13 showed high levels of TG (>150 mg/dl) in 63(33%). However, Siniawski et al, 12 in reported altogether different results showing nonsignificant changes in TG levels.…”

Section: Discussionmentioning

confidence: 90%

Variations in Lipid Profile During Critical Illness

Hassan

Sharif²,

Ijaz³

et al. 2022

PAFMJ

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Objective: To determine to mean change in levels of Triglycerides (TG), Total cholesterol (TC), High-Density Lipoprotein Cholesterol (HDL-C), and low-density lipoprotein (LDL-C) in critically ill patients at admission,18 hours and 42 hours after admission. Study Design: Cross-sectional study Place and Duration of Study: Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology Rawalpindi (AFIP), in collaboration with Military Hospital Rawalpindi (MH), Combined Military Hospital Rawalpindi (CMH) and Armed Forces Institute of Cardiology Rawalpindi (AFIC) Pakistan, from Mar to Sep 2016. Methodology: A total of Fifty patients admitted to intensive care units of MH, CMH and AFIC for coronary artery disease(CAD), sepsis, burns and cancer were included in the study. Patients on lipid-lowering drugs and post-surgery patients were excluded.TC, HDL-C, LDL-C and TG were analysed on ADVIA 1800 (SIEMENS, Germany). Results: Fifty patients were included with mean age of 48.12±2.26 years. Parametric analyses revealed significant increase in serum TG levels during hospitalization in critically ill patients in various disease groups (Mean±SD at admission, 18 hours and 42 hours): TG (CNS disorders 1.35±0.18, 1.78±0.24 and 1.22±0.17; CVS 1.92±0.21, 2.15±0.28 ,2.32 ±0.20; sepsis 1.55±0.18,1.38+0.24,1.54+0.17; malignancies 1.24±0.31, 1.28+0.42,1.35+0.30; renal disorders 1.39+0.35,1.82+0.47,1.08+0.33; (p<0.05). TC decreased in sepsis, CVS and cancer patients while increasing in CNS and renal disorders. HDL-C and LDL-C decreased in all diseases as an acute stress response. Conclusions: During critical illness, TG and LDL-C may change significantly; therefore, they should be monitored and interpreted with extreme care if requested to be performed within the course of the disease.

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“…65, No. 1 (2022) lipoprotein (VLDL) receptors can bind to and mediate the catabolism of Lp (a) by endocytosis, leading to its degradation within lysosomes, leading to a cellular accumulation of lipids within macrophages [13,14].…”

Section: Fetuin-a (Human Fetuin-a or Alpha-2 Heremansmentioning

confidence: 99%

Evaluation of Vimentin and Some Biochemical Parameters in the Blood of Acute Myocardial Infarction Patients

et al. 2021

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Aim of the work: The aim of this study was to evaluate Vimentin, Fetuin-A, and Lipoprotein(a) (Lp(a) levels in the sera of Acute Myocardial Infarction (AMI) patients and to determine its relation with disease activity and severity. Patients and methods: Fifty three adult AMI patients (26 females and 27 males) and 41 healthy subjects (23 males and 18 females) matching age serving as the control group, were included in this study. Five milliliters of blood were collected from patients and control, then centrifuged and the serum was separated and frozen as aliquots at -20 o C until use. Measurement of the serum Vimentin, Fetuin-A, and Lp(a) levels in AMI patients and control was done using the ELISA Kit. Results: Serum levels of Vimentin, and Lp(a)were significantly increased in AMI patient as compared to control group. Serum Fetuin-A, albumin, and Total proteins level in patients with Acute myocardial Infarction was significantly lower than control group. Hence present study concluded that Vimentin, Fetuin-A, and Lp(a) could be a useful marker for disease activity in AMI.

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Evaluation of serum lipoprotein (a) in young patients with myocardial infarction

Cited by 4 publications

References 11 publications

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Lipid Levels in Acute Coronary Syndromes Admitted in Medical Intensive Care Unit in a Tertiary Care Hospital

Variations in Lipid Profile During Critical Illness

Evaluation of Vimentin and Some Biochemical Parameters in the Blood of Acute Myocardial Infarction Patients

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