Evaluation of resistance mechanisms and serotype and genotype distributions of macrolide-resistant strains in clinical isolates of Streptococcus pneumonia in Aydın, Turkey

Telli, Murat; Eyigör, Mete; Gültekin, Berna; Aydın, Neriman

doi:10.1007/s10156-011-0238-x

Cited by 10 publications

(10 citation statements)

References 22 publications

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“…In agreement with this finding, other studies in the Turkey, China and Taiwan showed that the ermB gene was the most frequent macrolide resistance determinant. while the most common resistance gene in the Canada and United States was mefA/E gene [20,21]. In this study the rate of co resistance related to ermB and mefA/E gens was found in 23% of isolates which accordance with a report from Turkey (20%) [20].…”

Section: Discussionsupporting

confidence: 90%

“…while the most common resistance gene in the Canada and United States was mefA/E gene [20,21]. In this study the rate of co resistance related to ermB and mefA/E gens was found in 23% of isolates which accordance with a report from Turkey (20%) [20]. As for frequency of double resistance to erythromycin and clindamycin has been spread globally.…”

Section: Discussionsupporting

confidence: 88%

“…The majority of macrolide-resistant strains 75% (24/32) were also resistant to tetracycline. This association is due to the insertion of ermB into composite transposons of the Tn916 family that contain tetM gene [7,20,23]. While, the existence of unexpressed tetM genes in tetracycline sensitive isolates showed that transposons of the Tn916 family may be more widespread in S. pneumonia than expected to firmly associated with resistant tetracycline [23,24].…”

Section: Discussionmentioning

confidence: 99%

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Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Beheshti

Jabalameli

Feizabadi

et al. 2020

Preprint

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Background: Streptococcus pneumoniae causes serious infections worldwide. The aim of this study was to determine the molecular characteristic, antibiotic resistance pattern and capsular types of invasive S. pneumonia in Tehran, Iran. Results: Of the 44 pneumococcal invasive isolates, 39 (89%) were isolated from children and 5 (11%) from adults. The results show that all pneumococcal isolates were susceptible to linezolid but had varying resistance to trimethoprim-sulfamethoxazole (86%), erythromycin (73%), tetracycline (66%), clindamycin (43%), penicillin (16%), chloramphenicol (14%) and levofloxacin (2%). The range of erythromycin, tetracycline and penicillin MICs were 2 - ≥ 256 μg/mL, 4 - ≥ 48 μg/mL, and 0.047 - ≥ 256 respectively. All of the penicillin resistant isolates were multidrug resistant (MDR) and in addition to penicillin were resistant to tetracycline, erythromycin and trimethoprim-sulfamethoxazole. The most common capsular types detected in 64% of the pneumococcal isolates was 6A/B, 19A, 15A, 23F. The multilocus sequence typing (MLST) of 10 pneumococcal isolates revealed 9 different sequence types (STs), including ST 15139 (capsular type 19A) and ST 15140 (capsular type 23F), which have not previously been reported.Conclusions: The study revealed that the S. pneumonia isolates belonged to diverse capsular types and clones with high rate of resistance to erythromycin, tetracycline, and penicillin.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Beheshti

Jabalameli

Feizabadi

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Of these serogroup 19 was frequently detected from children ≤2 years old but the proportion gradually reduced with increasing ages up to ≤18 years old with the majority (66.2%) of PNSP being detected in younger children [132]. It was surprising that the rate of penicillin resistance remained fairly low (6% -13%) despite the easy availability even without prescription in Turkey [130,181]. The rising incidence of PNSP in Turkey had been reported previously [182].…”

Section: Turkeymentioning

confidence: 92%

Current Trend in Pneumococcal Serotype Distribution in Asia

Le¹,

Yusof²,

Sekaran³

2014

J Vaccines Vaccin

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Asia is one of the continents in the world heavily impacted by pneumococcal diseases but yet the information on disease burden and serotype distribution remained largely unclear. The data is essentially needed to inform the burden of pneumococcal diseases as a priority public health concern among the Asian countries. The formulations of pneumococcal conjugate vaccines (PCV) included a number of prevailing serotypes in the Western world but geographical and temporal variations of vaccination effectiveness could be expected in Asia. This review focuses specifically on the most recent five years trend in serotype distributions from both invasive and non-invasive pneumococcal diseases in Asia. Other important features such as antimicrobial resistance and associated clones were also noted. All latest studies reported that complied with the scopes of this review were included and the serotyping data were extracted for comparison analysis between countries, regions, and to represent Asia as the whole. The most common serotypes detected in highest to lowest frequencies order are 19F, 14, 23F, 6B, 19A, 3, and 6A, accounted for approximate two third of the incidences. Heptavalent PCV (PCV7) is expected to cover half of the incidences with significant increment in efficacy with PCV13. East Asia, Southeast Asia, and West Asia have relatively similar serotype distributions though slight variations were observed. The more unique pattern is noted in South Asia region. Initiation of surveillance study in countries with no reporting data is needed. Continued surveillance involving nationwide or multinational collaborative networks need to be set up to enhance and standardize the reporting incidences.

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“…Prema podacima iz literature, početkom dvehiljaditih MLS fenotip bio je dominantan u Španiji i veći-ni evropskih zemalja, dok je M-fenotip bio znatno češći u Severnoj Americi, Engleskoj i Grčkoj. Skorašnji podaci iz Turske, Španije i Irana (17,18,19) pokazuju da je i u tim sredinama, kao i kod nas, najčešći fenotip cMLS. U Južnoj Americi i Saudijskoj Arabiji i dalje je najčešći fenotip M (20,21).…”

Section: Diskusijaunclassified

Frequency of resistance to penicillin and erythromycin of pneumococcal strains that caused ottis media

L¹,

Isailović²,

Opavski³

2017

Med podmladak

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Intoduction: Streptococcus pneumoniae is an important human pathogen and the most common cause of acute otitis media (AOM), especially in children. It is also a common cause of community acquired pneumonia, sepsis and bacterial meningitis. Drug of choice in the treatment of these disease are beta lactam antibiotics, and the first alternative are macrolides. The increasing prevalence of resistance to penicillin and macrolides, among pneumococci, has considerably complicated the treatment. Aim: The aim of this study was to determine susceptibility of pneumococcal isolates from pediatric AOM in Serbia to antibiotics. Material and methods: Antimicrobial susceptibility testing of 61 pneumococcal AOM was performed, collected from December 2014 to December 2015, using disk diffusion method and E test. Macrolide resistance profile was determined by double disk diffusion test. Results: In our study, 40 strains (65.6%) showed reduced sensitivity to penicillin and erythromycin. There were 9 (14.8%) high resistant isolates to penicillin, while 31 (50.8%) showed reduced susceptibility. The most frequent resistance phenotype was cMLS. Co-resistance to penicillin and macrolides was found in 14.8% strains. Conclusion: Our results showed high resistance rate of S. pneumoniae, which causes AOM among children, to penicillin and macrolides. Further active surveillance of pneumococcal susceptibility to antibiotics is necessary, and use of these medications in empirical therapy should be limited.

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Evaluation of resistance mechanisms and serotype and genotype distributions of macrolide-resistant strains in clinical isolates of Streptococcus pneumonia in Aydın, Turkey

Cited by 10 publications

References 22 publications

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumonia isolated from clinical samples in Tehran, Iran

Current Trend in Pneumococcal Serotype Distribution in Asia

Frequency of resistance to penicillin and erythromycin of pneumococcal strains that caused ottis media

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