Evaluation of remineralizing potential of Calcium Sucrose Phosphate and CPP-ACP: An in vitro study

Rani, S Thabitha; Manjula, M; Reddy, E Rajendra; VinayKumar, L.; Mohan, Tulluru Ajay; Sowmya, B

doi:10.1016/j.pdj.2016.07.002

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…(VHN 263-345). [ 27 28 ] The induced DEM had a VHN that was significantly less than the VHN of sound enamel, similar to Thabitha et al . and Lata et al .…”

Section: Discussionsupporting

confidence: 72%

“…and Lata et al . [ 28 29 ] The REM of enamel after the application of four different remineralizing agents and post-pH cycling witnessed significant differences in VHN values between the groups. It was found that P11-4 had the highest VHN and CPP-ACPF had the lowest VHN.…”

Section: Discussionmentioning

confidence: 99%

“…found that CSP had significantly higher mean SMH than CPP-ACP in addition to reducing the lesion depth. [ 28 39 ] A study by Veeramani et al . found CSP to be an agent of choice for primary dentition.…”

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study

Xavier,

Thomas,

Jose

et al. 2024

Journal of Conservative Dentistry and Endodontics

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Aim: The study aimed to assess the remineralizing potential of four different commercially available agents using a Scanning Electron Microscope (SEM), energy dispersive X-ray (EDX) analysis, and Vickers Microhardness (VMH) Test. Materials and Methods: Forty-four specimens (n = 11 per group) were prepared from extracted teeth. A window of 6 mm × 4 mm was made on all the specimens that represented three zones, namely, sound enamel, demineralized enamel, and remineralized enamel. The zone for demineralized enamel was subjected to four different remineralizing agents; casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF), tricalcium phosphate fluoride (TCP-F), calcium sucrose phosphate (CSP), and self-assembling peptide (P11-4). Remineralization (REM) was assessed using VMH; the structural changes were assessed using SEM that was analyzed using EDX analysis. The specimens were subjected to a newer regimen of demineralization. One-way ANOVA followed by post hoc Tukey test was used with a level of significance at P ≤ 0.05. Results: There were no significant differences in VMH between the groups for sound enamel (P = 0.472) and demineralized enamel (P = 0.116). VMH was statistically significantly more for P11-4 and the least for CPP-ACPF (P = 0.011). A post hoc analysis revealed higher VMH for P11-4 compared to CPP-ACPF (P = 0.014) and TCP-F (P = 0.035). SEM showed a homogeneous layer of minerals for all groups except CPP-ACPF. TCP-F reported a higher degree of REM, followed by P11-4 as assessed using EDX analysis. Conclusion: Self-assembling peptide (P11-4) exhibited a higher degree of REM than other remineralizing agents followed by CSP.

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“…(VHN 263-345). [ 27 28 ] The induced DEM had a VHN that was significantly less than the VHN of sound enamel, similar to Thabitha et al . and Lata et al .…”

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study

Xavier,

Thomas,

Jose

et al. 2024

Journal of Conservative Dentistry and Endodontics

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“…[ 1 ] It is a mixture of calcium sucrose mono- and diphosphate, disucrose monophosphate, and inorganic calcium phosphate that contains 11% calcium, 9.5% organic phosphate, and 2.5% inorganic phosphate, respectively. [ 26 ] It soon breaks down into calcium ions, phosphate ions, and sucrose phosphate ions in saliva, thereby permitting creation of an aqueous solution consisting of very high concentration of calcium and phosphate while simultaneously preventing precipitation. [ 25 27 ]…”

Section: Discussionmentioning

confidence: 99%

“…One percent anticay provides 30 × 10 −3 M Ca, 10 × 10 −3 M PO 4 , and 20 × 10 −3 M sucrose phosphate compared to saliva which contains 1.4 × 10 −3 M Ca and 4 × 10 −3 M P0 4 , thereby serving an as ideal remineralizing agent. [ 17 28 ] It is shown to reduce the rate of acid solubility of enamel and increase its rate of remineralization by common ions effect,[ 17 18 26 28 29 ] inhibits the formation of plaque and its adherence to enamel,[ 26 28 30 ] and inhibits the formation of acid in plaque. [ 28 30 31 ] In this study, Enafix ™ toothpaste (Group Pharmaceuticals Limited, India) was used to evaluate and compare the efficacy of CaSP toothpaste with ordinarily used calcium and phosphate-containing toothpaste in elevating the level of calcium, phosphate ions in saliva.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a calcium sucrose phosphate based toothpaste in elevating the level of calcium, phosphate ions in saliva and reducing plaque: A clinical trial

et al. 2018

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Aim:To evaluate and compare the efficacy of “calcium sucrose phosphate” (CaSP) toothpaste (Enafix 5%) with ordinarily used calcium, phosphate-containing toothpaste in elevating the level of calcium, phosphate ions in saliva. Secondary aims were to evaluate substantivity and plaque-reducing ability of CaSP toothpaste.Materials and Methods:Thirty study participants of age group 6–13 years were divided into two groups: Group X (Control group) was made to continue brushing with their regularly used calcium, phosphate-containing toothpaste and Group Y (Test group) was allotted CaSP toothpaste. 1 ml of unstimulated saliva was periodically collected from both groups to determine any alteration in the salivary calcium, phosphate level. Parameters such as substantivity and plaque-reducing ability of CaSP toothpaste were also evaluated. Salivary mineral's intergroup comparison was evaluated by Student's t-test while its intragroup comparison along with the plaque amount variation in Group Y was evaluated by ANOVA and Tukey's post hoc test.Results:Group Y showed an increase in the salivary calcium level though not statistically significant. The increase was pronounced in samples collected on day 1. Group Y showed a consistent level of calcium, phosphate in samples collected immediately and 6 h postbrushing, indicating its substantivity. In addition, Group Y had an impact in reducing the plaque level when the 1st-month plaque score was compared with the 12th-month score.Conclusion:CaSP leads to an increase in the salivary calcium level though it was not statistically significant. Supervised brushing and dietary habits showed a positive effect on both the groups. CaSP toothpaste also showed substantivity and plaque-reducing ability.

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Remineralizing potential of Calcium Sucrose Phosphate in white spot lesions: A Systematic Review

Rout,

Patil,

Deshmukh

et al. 2024

Journal of Oral Biosciences

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Evaluation of remineralizing potential of Calcium Sucrose Phosphate and CPP-ACP: An in vitro study

Cited by 10 publications

References 21 publications

Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study

Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study

Efficacy of a calcium sucrose phosphate based toothpaste in elevating the level of calcium, phosphate ions in saliva and reducing plaque: A clinical trial

Remineralizing potential of Calcium Sucrose Phosphate in white spot lesions: A Systematic Review

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