Evaluation of protein safety in the context of agricultural biotechnology

Delaney, Bryan; Astwood, James D.; Cunny, Helen; Conn, R.E.; Hérouet-Guicheney, Corinne; MacIntosh, Susan; Meyer, Linda; Privalle, Laura; Gao, Yong; Mattsson, Joel L.; Levine, Marci J.

doi:10.1016/j.fct.2008.01.045

Cited by 156 publications

(125 citation statements)

References 83 publications

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“…Prior to making any GM crops, all potential proteins that would be produced by the inserted gene (called a "transgene") are screened using computer algorithms to ensure that they are not similar to known allergens, toxins, antinutritional proteins, disease agents, or pharmacologically active proteins (Delaney et al, 2008;Silvanovich et al, 2009;Hammond et al, 2013). For example, comparing candidate proteins to known allergens is typically done using sequence alignment programs, such as BLAST or FASTA, and by using a so-called sliding eight-amino-acid window search.…”

Section: Breeding Of Gm Crops Sources Of Candidate Genes For Gm Cropsmentioning

confidence: 99%

Bringing New Plant Varieties to Market: Plant Breeding and Selection Practices Advance Beneficial Characteristics while Minimizing Unintended Changes

et al. 2017

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Commercial‐scale plant breeding is a complex process in which new crop varieties are continuously being developed to improve yield and agronomic performance over current varieties. A wide array of naturally occurring genetic changes are sources of new characteristics available to plant breeders. During conventional plant breeding, genetic material is exchanged that has the potential to beneficially or adversely affect plant characteristics. For this reason, commercial‐scale breeders have implemented extensive plant selection practices to identify the top‐performing candidates with the desired characteristics while minimizing the advancement of unintended changes. Selection practices in maize (Zea mays L.) breeding involve phenotypic assessments of thousands of candidate lines throughout hundreds of different environmental conditions over many years. Desirable characteristics can also be introduced through genetic modification. For genetically modified (GM) crops, molecular analysis is used to select transformed plants with a single copy of an intact DNA insert and without disruption of endogenous genes. All the while, GM crops go through the same extensive phenotypic characterization as conventionally bred crops. Data from both conventional and GM maize breeding programs are presented to show the similarities between these two processes.

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Section: Breeding Of Gm Crops Sources Of Candidate Genes For Gm Cropsmentioning

confidence: 99%

Bringing New Plant Varieties to Market: Plant Breeding and Selection Practices Advance Beneficial Characteristics while Minimizing Unintended Changes

et al. 2017

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“…Such analyses might include a determination of expression levels of known allergens and toxins, and overall composition, including nutrients, antinutrients, and selected metabolites for that crop (FAO/WHO, 1996Cellini et al, 2004;Codex Alimentarius Commission, 2009;Thomas et al, 2009). Assessments of nutrient composition and agronomic characteristics, as well as an assessment of potential allergenicity and toxicity, are widely recognized as significant components of GE crop safety assessments (FAO/WHO, 1996Metcalfe et al, 1996;Kuiper et al, 2001;Cellini et al, 2004;Delaney et al, 2008;Codex Alimentarius Commission, 2009;Thomas et al, 2009). Differences between the GE crop and appropriate comparators are evaluated in terms of biological relevance, magnitude of difference, exposure, and impact on food or feed safety to determine the need for further investigation.…”

Section: Interaction (Between Events)mentioning

confidence: 99%

Editor’s Choice: Evaluating the Potential for Adverse Interactions within Genetically Engineered Breeding Stacks

Steiner¹,

Halpin

Jez

et al. 2013

Plant Physiol.

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“…Characterization of both physical and function parameters are involved. A complete description of the safety assessment of the protein is described by Delaney et al (2008) and Hammond (2008). Examples for specific proteins are described in Raybould et al (2013), Privalle et al (2000), Hérouet et al (2005) and Madduri et al (2012).…”

Section: Status Of Regulation Todaymentioning

confidence: 99%

The Story Behind the Approval of the First Bt Maize Product

Privalle

2017

Women in Sustainable Agriculture and Food Biotechnology

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Evaluation of protein safety in the context of agricultural biotechnology

Cited by 156 publications

References 83 publications

Bringing New Plant Varieties to Market: Plant Breeding and Selection Practices Advance Beneficial Characteristics while Minimizing Unintended Changes

Bringing New Plant Varieties to Market: Plant Breeding and Selection Practices Advance Beneficial Characteristics while Minimizing Unintended Changes

Editor’s Choice: Evaluating the Potential for Adverse Interactions within Genetically Engineered Breeding Stacks

The Story Behind the Approval of the First Bt Maize Product

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