Evaluation of post-radiofrequency myocardial injury by measuring cardiac troponin I levels

Biomarkers of myocardial injury with different energy sources for atrial fibrillation catheter ablation

“…In our study, the higher cTnI and CK-MB levels in cryoballoon group may be explained by longer energy delivery duration compared to the other groups. Previous AF ablation studies have found a correlation between levels of cTnT and RF delivery duration and cumulative RF energy [24,27,28], but no data exist regarding other energy sources. Apart from the energy delivery duration, other factors may contribute to higher degree of myocardial injury in cryoablation, as suggested by increased levels of biomarkers post ablation.…”

“…Electrode orientation, contact pressure and blood velocity are the main factors involved in lesion formation. During cryoablation larger contact surface between the cryoballoon catheter and the endocardial tissue and the complete occlusion of the PV minimizing convective warming of the local blood velocity may create larger lesions [10,28].…”

Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

“…Therefore, the RF procedure can serve as a sensitive model for evaluating the sensitivity of cardiac markers to detect minor small injuries. This concept was proven in studies with cardiac troponins 14,15 , creatine kinase 16 and novel markers, e.g. glycogen phosphorylase BB, and fatty acid binding protein 17 .…”

Myocardial injury during radiofrequency and cryoablation of typical atrial flutter

“…Ablation in the ventricles and atrial fibrillation ablations with long linear lesions can result in large necrotic areas and marked cardiac enzyme elevation post procedure [9,11,16,20]. Previous studies found higher levels of myocardial injury enzymes after CRYO treatment than after RF treatment [15,17].…”

“…Both total myocardial injury and the amount of necrosis are higher in AFL catheter ablation compared to ablations of other atrial arrhythmias, except atrial fibrillation, due to the larger size of the ablated area and the greater amount of transferred energy [9,10]. Cardiac enzyme elevations after RF ablation are commonly reported [11][12][13][14]. Compared to RF treatment, CRYO treatment is associated with more pronounced cardiac enzyme elevation but less systemic inflammatory reaction and is attributed to a different lesion formation [15][16][17].…”