Evaluation of peripapillary vascular flow in patients with Thyroid-Associated Ophthalmopathy (TAO) by OCT Angiography

Noce, Chiara Del; Roda, Matilde; Valsecchi, Nicola; Guandalini, Sofia; Geronimo, Natalie di; Schiavi, Costantino; Traverso, Carlo Enrico; Vagge, Aldo

doi:10.1007/s00417-022-05551-7

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…OCTA, a novel noninvasive technique, was recently adopted to quantitatively measure retinal and choroidal microvasculature in different ocular and systemic diseases, such as glaucoma (27,28), age-related macular degeneration (29-31), optic neuropathies (32-35), leukemia (36), diabetic retinopathy (37)(38)(39)(40), and TAO (14,19,20,41,42), and to evaluate the severity and prognosis of these diseases. Our study showed that the macular retinal VD was significantly decreased in the ODE and NODE groups compared with the normal group.…”

Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography angiography (OCTA), a noninvasive and quantitative technique, has been used to evaluate retinal and choroidal microvascular density (VD) in TAO patients (12)(13)(14)(15)(16)(17) and has been used to diagnose and monitor the early stage of vision-threatening TAO (18)(19)(20)(21). Our previous study on OCTA reported that the vessel density (VD) of the retinal macula and radial peripapillary capillaries (RPCs) was decreased in CRF patients compared with TAO patients without CRFs (11).…”

Section: Introductionmentioning

confidence: 99%

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Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema

et al. 2023

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PurposeThe aim of this study was to evaluate the vessel density (VD) of the macular choriocapillaris (CC) and retina in thyroid-associated ophthalmopathy (TAO) patients with chorioretinal folds (CRFs) with and without optic disc edema (ODE) and the correlations of these characteristics with visual function.MethodThis was a cross-sectional study. Twenty TAO patients with CRFs (35 eyes) and 20 normal subjects (normal group, 40 eyes) were recruited at the Ophthalmology Department of the Sun Yat-sen Memorial Hospital from March 2018 to October 2022. Then, CRF patients were divided into two groups, the ODE and non-ODE groups (NODE), based on the presence or absence of ODE. All the patients underwent optical coherence tomography angiography (OCTA) and the VD of the macular CC and retina was computed. The correlation of VD and visual function was analyzed.ResultsCompared with the normal group, the macular whole-image VD in the retinal superficial layer (SLR-mwiVD: 49.82 ± 3.38 in the normal group, 42.44 ± 5.40 in the NODE group, and 42.51 ± 5.37 in the ODE group), deep layer (DLR-mwiVD: 51.05 ± 6.23 in the normal group, 45.71 ± 6.66 in the NODE group, and 46.31 ± 5.48 in the ODE group), and CC (CC-mwiVD: 70.23 ± 2.47 in the normal group, 68.04 ± 3.73 in the NODE group, and 63.09 ± 6.51 in the ODE group) was decreased in the NODE (all p < 0.05) and ODE group (all p < 0.01). There was no difference in these parameters except CC-mwiVD between the ODE and NODE groups. The CC-mwiVD in the ODE group (63.09 ± 6.51) was significantly reduced compared with that in the NODE group (68.04 ± 3.73, p = 0.004). All these VD parameters were negatively correlated with BCVA, VF-PSD, and P100 latency and positively associated with VF-MD, P100 amplitude, and HRR scores (all p < 0.05).ConclusionsThere was a significant decrease in the VD of the macular CC and retina of patients with CRFs with or without ODE, which was correlated with visual dysfunction. The VD of the macular CC in CRF patients with ODE was significantly reduced compared with that in the NODE group, but similar results were not observed in the retina.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema

et al. 2023

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“…In another study by Del Noce et al, there was a significant decrease in the peripapillary choriocapillaris and deep capillary plexus VD in patients with TED compared to healthy age and gender-matched controls. The study demonstrates a significant relationship between higher CAS scores and lower peripapillary choriocapillaris VD [ 19 ]. These studies showed significant alteration in ONH VD in patients with higher CAS scores like ours.…”

Section: Discussionmentioning

confidence: 99%

Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study

et al. 2022

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Background To evaluate changes in the vessel density (VD) of the optic nerve head (ONH) microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA). This study aimed to applicate the OCTA as a noninvasive modality in screening TED patients to assess sub-clinical changes. Methods In a cross-sectional study, the control group patients were healthy individuals with no ocular abnormalities and were euthyroid. All patients with TED had clinical features of the disease. We divided them into two groups using the clinical activity score (CAS). Patients with CAS scores 0–2 were categorized as group A, and scores three or more as group B. All vessels (AV) and small vessels (SV) VD inside disc and radial peripapillary capillary network were measured using the ONH-OCTA. Results We evaluated 29 patients with TED and 28 healthy controls. The mean whole image AV VD (mean ± SD: 56.33 ± 2.56, p-value = 0.17) and the mean whole image SV VD (mean ± SD: 49.94 ± 2.56, p-value = 0.16) in the TED group had no statically significant difference compared with the control group (AV mean ± SD: 57.20 ± 20.22, SV mean ± SD: 50.84 ± 2.23). We found a non-significant decrease in AV and SV radial peripapillary capillary VD in the TED group. There was a significant decrease in the mean whole image AV VD (mean ± SD: 54.83 ± 3.07, p-value = 0.005) and the mean whole image SV VD (mean ± SD: 48.60 ± 3.18, p-value = 0.013) in CAS group B compared to group A (AV mean ± SD: 57.45 ± 1.33, SV mean ± SD: 50.95 ± 1.37). Conclusion Our study showed non-significant ONH vascular alterations in patients with TED, including reduced VD of ONH in the radial peripapillary capillary. Patients with higher CAS scores had a more noticeable decrease in ONH microvasculature.

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“…The same autoimmune disorder that causes Graves’ orbitopathy also attacks thyroid gland resulting in thyroid overactivity (hyperthyroidism) also called Graves’ disease [50]. On OCTA, Ye et al [51] demonstrated that there is increased retinal microvascular density in patients with active TED compared with controls, which also correlated with visual acuity while in the recent study of del Noce et al [52 ▪▪ ] peripapillary blood flow indices were lower in TED patients in both deep capillary plexus and choriocapillaris layers with the latter being correlated with disease activity. Furthermore, decrease in peripapillary and macular vascular density as well as increase in RNFL thickness are noted in active TED compared with inactive TED and healthy eyes [53 ▪ ].…”

Section: Introductionmentioning

confidence: 98%

Optical coherence tomography angiography in neuro-ophthalmology

Douglas

Torun

2023

Current Opinion in Ophthalmology

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Purpose of reviewOptical coherence tomography angiography (OCTA) is a novel, noninvasive imaging technique, which provides depth resolved visualization of microvasculature of the retina and choroid. Although OCTA has been widely used for the evaluation of a number of retinal diseases, its use in the field of neuro-ophthalmology has been less studied. In this review, we provide an update on the utility of OCTA in neuro-ophthalmic conditions. Recent findingsPeripapillary and macular microvasculature analyses have indicated that OCTA can be a promising tool for early detection of a number of neuro-ophthalmic diseases, differential diagnosis, and monitoring of disease progression. Recent studies have demonstrated that structural and functional impairment can develop at early stages in some conditions such as in multiple sclerosis and Alzheimer's disease even in the absence of overt clinical symptoms. Furthermore, this dye-less technique can be a valuable adjunct tool in the detection of complications commonly seen in some congenital entities such optic disc drusen.

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Evaluation of peripapillary vascular flow in patients with Thyroid-Associated Ophthalmopathy (TAO) by OCT Angiography

Cited by 6 publications

References 24 publications

Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema

Decreased macular choriocapillaris in thyroid-associated ophthalmopathy: focusing on chorioretinal folds with and without optic disc edema

Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study

Optical coherence tomography angiography in neuro-ophthalmology

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