Evaluation of olfactory function in children with seasonal allergic rhinitis and its correlation with acoustic rhinometry

Aksoy, Ceren; Elsürer, Çağdaş; Artaç, Hasibe; Bozkurt, Mete Kaan

doi:10.1016/j.ijporl.2018.07.051

Cited by 20 publications

(39 citation statements)

References 20 publications

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“…The tests we used in this study were created on the basis of already validated and widely used olfactory and gustatory evaluation protocols. [9][10][11][12][13][14][15][16] The scoring system was established so that the results of the two tests would be comparable.…”

Section: Discussionmentioning

confidence: 99%

“…The Connecticut Chemosensorial Clinical Research Center (CCCRC) orthonasal olfaction test [12][13][14][15][16] was used to evaluate the olfactory function. As required by the test protocol, olfactory threshold was determined by means of 60 mL of deionized water, with increasing concentration of N-butyl-alcohol.…”

Section: Operator-administered Olfactory and Gustatory Testmentioning

confidence: 99%

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Validation of a self‐administered olfactory and gustatory test for the remotely evaluation of COVID‐19 patients in home quarantine

Vaira

Salzano²,

Petrocelli³

et al. 2020

Head & Neck

125

168

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Background: Chemosensitive disorders are very frequent in the early stages of COVID-19 and in paucisymptomatic cases. These patients are typically placed in home quarantine. This study has the aim of validating a new olfactory and gustatory objective evaluation test in these patients. Methods: Thirty-three home-quarantined COVID-19 patients have undergone a self-administered chemosensitive test the day before the control swab. On this occasion, the patients underwent operator-administered already validated tests. The results were finally compared. Results: The differences between the results of the two tests were not significant for both the olfaction (P =.201) and the taste (P =.180). Conclusion:The olfactory and gustatory evaluation by self-administered test can be considered a valid tool, fundamental for obtaining objective qualitative and quantitative data on the extent of chemosensitive disorders in homequarantined COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

Section: Operator-administered Olfactory and Gustatory Testmentioning

confidence: 99%

Validation of a self‐administered olfactory and gustatory test for the remotely evaluation of COVID‐19 patients in home quarantine

Vaira

Salzano²,

Petrocelli³

et al. 2020

Head & Neck

125

168

View full text Add to dashboard Cite

show abstract

“…However, when the disease duration was more than 10 years, the symptoms of olfactory disorders became disturbing in both groups. These ndings indicate that with the progression of the disease, olfactory dysfunction becomes more signi cant in non-eCRSwNP patients, probably because the reduplicate stimulation destroys the epithelium in the context of chronic in ammation (28,30).…”

Section: Discussionmentioning

confidence: 88%

“…In vitro studies have found that ECP gradually increases after exposure to pollen, and the increase is associated with the progression of hyposmia. Nevertheless, ECP can slower the frequency of nasal ciliary movement, even in the epithelial cells (30). All these complicated factors make the sensory receptor fragile to the pathologic stimuli (25,27).…”

Section: Discussionmentioning

confidence: 99%

Olfactory Disorder is The Specific Symptom to Distinguish Eosinophilic From Non-Eosinophilic Nasal Polyps

Pan

Zhang

Zhang³

2020

Preprint

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Background: Patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) have poorer outcomes after endoscopic sinus surgery and a higher recurrence rate. This study aimed to investigate the profile of clinical symptoms of eCRSwNP and the related risk factors.Methods: We prospectively enrolled 298 CRSwNP inpatients from February 2019 to December 2019. Patients were divided into eCRSwNP and non-eCRSwNP groups based on the percentage of blood eosinophils. Clinical data on questionnaires, visual analogue scale (VAS) scores, and laboratory tests were collected. The differences in clinical symptoms, including nasal congestion, rhinorrhea, olfactory disorders, and head/facial pain, between the two groups were analyzed to identify the influential factors. Logistic analysis and receiver operating characteristic curves were used to determine the diagnostic benefit for the specific symptom in eCRSwNP patients.Results: Of the four major clinical symptoms, nasal congestion and olfactory disorders were significantly different between eCRSwNP and non-eCRSwNP groups. Patients with eCRSwNP more frequently complained about olfactory disorders (P = 0.002), while patients with non-eCRSwNP mostly had nasal congestion (P = 0.001). The logistic analysis showed that the primary risk factors for olfactory disorders of eCRSwNP were disease duration (P = 0.014) and alcohol intake (P = 0.012). Olfactory disorders were not associated with the disease course of eCRSwNP but were correlated with the disease duration of non-eCRSwNP (P = 0.008). When the clinical duration was less than 10 years, there was a significant difference in olfactory disorders between eCRSwNP and non-eCRSwNP groups (P < 0.01). However, when the clinical duration was over 10 years, the difference was not statistically significant (P = 0.264). The VAS score of olfactory disorders of over 5.75 could be used to predict the diagnosis of eCRSwNP (area under the curve ＝0.674, 95% confidence intervals: 0.559–0.689, P = 0.000). Conclusions: Olfactory disorder was the major nasal symptom that could be used to distinguish eCRSwNP and non-eCRSwNP. ECRSwNP patients were more prone to have olfactory dysfunction. Our findings suggest that evaluation of nasal symptoms will help diagnose eCRSwNP and determine subsequent clinical treatment strategies.

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“…In vitro studies had found that ECP gradually increased after exposure to pollen, and the increase was associated with the progression of hyposmia. Nevertheless, ECP can slower the frequency of nasal ciliary movement, even in the epithelial cells (30). All these complicated factors made the sensory receptor fragile to the pathologic stimuli (25,27).…”

Section: Discussionmentioning

confidence: 99%

Olfactory Disorder is the Specific Symptom to Distinguish Eosinophilic from non-eosinophilic Nasal Polyps

Pan

Zhang

2020

Preprint

View full text Add to dashboard Cite

Background: Patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) have poorer outcomes after endoscopic sinus surgery and a higher recurrence rate. This study aimed to investigate the profile of clinical symptoms of eCRSwNP and the related risk factors.Methods: We prospectively enrolled 298 CRSwNP inpatients from February 2019 to December 2019. Patients were divided into eCRSwNP and non-eCRSwNP groups based on the percentage of blood eosinophils. Clinical data on questionnaires, visual analogue scale (VAS) scores, and laboratory tests were collected. The differences in clinical symptoms, including nasal congestion, rhinorrhea, olfactory disorders, and head/facial pain, between the two groups were analyzed to identify the influential factors. Logistic analysis and receiver operating characteristic curves were used to determine the diagnostic benefit for the specific symptom in eCRSwNP patients.Results: Of the four major clinical symptoms, nasal congestion and olfactory disorders were significantly different between eCRSwNP and non-eCRSwNP groups. Patients with eCRSwNP more frequently complained about olfactory disorders (P = 0.002), while patients with non-eCRSwNP mostly had nasal congestion (P = 0.001). The logistic analysis showed that the primary risk factors for olfactory disorders of eCRSwNP were disease duration (P = 0.014) and alcohol intake (P = 0.012). Olfactory disorders were not associated with the disease course of eCRSwNP but were correlated with the disease duration of non-eCRSwNP (P = 0.008). When the clinical duration was less than 10 years, there was a significant difference in olfactory disorders between eCRSwNP and non-eCRSwNP groups (P < 0.01). However, when the clinical duration was over 10 years, the difference was not statistically significant (P = 0.264). The VAS score of olfactory disorders of over 5.75 could be used to predict the diagnosis of eCRSwNP (area under the curve ＝0.674, 95% confidence intervals: 0.559–0.689, P = 0.000). Conclusions: Olfactory disorder was the major nasal symptom that could be used to distinguish eCRSwNP and non-eCRSwNP. ECRSwNP patients were more prone to have olfactory dysfunction. Our findings suggested that evaluation of nasal symptoms would help diagnose eCRSwNP and determine subsequent clinical treatment strategies.

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Evaluation of olfactory function in children with seasonal allergic rhinitis and its correlation with acoustic rhinometry

Cited by 20 publications

References 20 publications

Validation of a self‐administered olfactory and gustatory test for the remotely evaluation of COVID‐19 patients in home quarantine

Validation of a self‐administered olfactory and gustatory test for the remotely evaluation of COVID‐19 patients in home quarantine

Olfactory Disorder is The Specific Symptom to Distinguish Eosinophilic From Non-Eosinophilic Nasal Polyps

Olfactory Disorder is the Specific Symptom to Distinguish Eosinophilic from non-eosinophilic Nasal Polyps

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