Evaluation of Lymphatic Spread, Visceral Metastasis and Tumoral Local Invasion in Esophageal Carcinomas

Tustumi, Francisco; Kimura, Cintia Mayumi Sakurai; Takeda, Flavio Roberto; Sallum, Rubens Antonio Aissar; Ribeiro, Ulysses; Cecconello, Ivan

doi:10.1590/0102-6720201600040001

Cited by 15 publications

(14 citation statements)

References 4 publications

(5 reference statements)

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“…Similarly to previous studies that included patients with distant disease at initial diagnosis or who developed distant metastasis during follow-up ( 8 , 9 ), we found the liver was the most common site of distant metastasis in esophageal cancer overall, followed by the lymph nodes, lung, bone and brain. Up to now, the patterns of distant metastasis in SCC and AC have been poorly defined.…”

Section: Discussionsupporting

confidence: 81%

“…We also observed SCC had a significantly higher risk of lung metastasis. Previous studies reported the frequency of lung metastasis was not significantly different between SCC and AC ( 9 , 10 ). In a study of 35 Chinese patients with SCC and distant metastasis, 22 (62.9%) had lung metastasis and two (5.8%) had liver metastasis ( 12 ).…”

Section: Discussionmentioning

confidence: 62%

“…Tustumi et al . found patients with AC were more likely to have liver metastasis than patients with SCC (13.7% vs. 24.5%, p = 0.002), with no significant difference in metastasis to lung (9.8% vs. 14.8%, p = 0.254), bone (11.8% vs. 8.4%, p = 0.416) or brain (4.9% vs. 2.5%, p = 0.524) ( 9 ). Quint et al also reported AC had a higher incidence of liver metastasis than SCC (37.9% vs. 9%, p < 0.001), with no significant differences in lung, bone, and brain metastasis ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

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Patterns of Distant Metastasis Between Histological Types in Esophageal Cancer

Zhang

Sun

et al. 2018

Front. Oncol.

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Introduction: Distant metastasis remains the major cause of treatment failure in esophageal cancer, though there have been few large-scale studies of the patterns of distant metastasis in different histological types. We investigated the patterns of distant metastasis in esophageal adenocarcinoma (AC) and squamous cell carcinoma (SCC) using a population-based approach.Methods: Patients with de novo stage IV esophageal cancer at diagnosis were identified using the Surveillance, Epidemiology, and End Results database. Multivariable logistic regression was performed to identify potential risk factors for site-specific distant metastasis to the distant lymph nodes, bone, liver, brain, and lung at diagnosis.Results: We identified 1,470 patients with complete data for analysis including 1,096 (74.6%) patients with AC and 374 (25.4%) patients with SCC. A total of 2,243 sites of distant metastasis were observed, the liver was the most common site of distant metastasis (727, 32.4%), followed by the distant lymph nodes (637, 28.4%), lung (459, 20.5%), bone (344, 15.3%), and brain (76, 3.4%). Multivariable logistic regression showed that compared to patients with SCC, patients with AC were more likely to have metastasis to the brain (odds ratio [OR] 3.026, 95% confidence interval [CI] 1.441-6.357, p = 0.003) and liver (OR 1.848, 95% CI 1.394–2.451, p < 0.001), and less likely to have metastasis to the lung (OR 0.404, 95% CI 0.316–0.516, p < 0.001). Histological type had no effect on metastasis to the distant lymph nodes or bone.Conclusions: Patients with esophageal AC are more likely to present with liver and brain metastases, and less likely to present with lung metastasis than patients with esophageal SCC.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Patterns of Distant Metastasis Between Histological Types in Esophageal Cancer

Zhang

Sun

et al. 2018

Front. Oncol.

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“…The chemotherapeutic agents were cisplatin and 5FU (scheme Al Sarraf - for 21 patients) and carbotaxol and cisplatin (n=13); this treatment was combined with radiotherapy 1 , 11 , 12 , 15 , 23 , 43 .…”

Section: Resultsmentioning

confidence: 99%

“…The neoadjuvant therapy as a therapeutic strategy in esophageal squamous cell carcinoma has been used for many years 19 , 20 . This neoadjuvance may be only preoperative radiotherapy in the tumor area or, more recently, the use of associated radiotherapy and chemotherapy, thus affecting the tumor area and possible metastases 15 , 43 .…”

Section: Discussionmentioning

confidence: 99%

Pathologic Complete Response (Ypt0 Ypn0) After Chemotherapy and Radiotherapy Neoadjuvant Followed by Esophagectomy in the Squamous Cell Carcinoma of the Esophagus

Andreollo

Beraldo

Alves

et al. 2018

ABCD, arq. bras. cir. dig.

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Background:Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated. Aim:Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Methods:Between 1983-2014, 222 esophagectomies were performed, and 177 were conducted to neoadjuvant treatment. In 34 patients the pathologic response was considered complete. Medical records of the patients were retrospectively reviewed regarding type of chemotherapy applied, amount of radiotherapy, interval between the neoadjuvant therapy and the surgery, body mass index; postoperative complications; hospital admission time and survival. Results:The average age was 55.8 years. Twenty-five patients were subjected to chemotherapy and radiotherapy, and nine to neoadjuvant radiotherapy. The total radiation dose ranged from 4400 until 5400 cGy. The chemotherapy was performed with 5FU, cisplatin, and carbotaxol, concomitantly with the radiotherapy. The esophagectomy was transmediastinal, followed by the cervical esophagogastroplasty performed on a average of 49.4 days after the neoadjuvant therapy. The hospital admission time was an average of 14.8 days. During the follow-up period, 52% of the patients submitted to radiotherapy and chemotherapy were disease-free, with 23.6% of them presenting more than five years survival. Conclusions:The neoadjuvant treatment followed by esophagectomy in patients with pathologic complete response is beneficial for the survival of patients with esophageal squamous cell carcinoma.

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Evaluation of Lymphatic Spread, Visceral Metastasis and Tumoral Local Invasion in Esophageal Carcinomas

Cited by 15 publications

References 4 publications

Patterns of Distant Metastasis Between Histological Types in Esophageal Cancer

Patterns of Distant Metastasis Between Histological Types in Esophageal Cancer

Pathologic Complete Response (Ypt0 Ypn0) After Chemotherapy and Radiotherapy Neoadjuvant Followed by Esophagectomy in the Squamous Cell Carcinoma of the Esophagus

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