Evaluation of long‐term function, complications, quality of life and health status after restorative proctocolectomy with ileo neo rectal and with ileal pouch anal anastomosis for ulcerative colitis

Heikens, Joost T.; Vries, Jolanda De; Jong, Dirk J. de; Oudsten, Brenda L. Den; Hopman, W. P. M.; Groenewoud, J.M.M.; Kolk, M.B. van der; Gooszen, Hein G.; Laarhoven, Cornelis J. H. M. van

doi:10.1111/codi.12175

Cited by 8 publications

(6 citation statements)

References 33 publications

(45 reference statements)

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“…Twelve studies assessed QoL in a variety of different patient populations, using a range of different methods and questionnaires (Table S2). Six studies assessed QoL in postoperative IPAA cohorts alone [23,25,26,30,33,48], two compared QoL before and after surgery for IPAA [28,54], two compared postoperative cohorts of IPAA to ileostomy [29,39] and two compared IPAA to continued medical therapy [42,53]. Due to the large variability in QoL questionnaires used, the variation in study populations and also inter-study variation of analysis of questionnaires, a formal synthesis of results was not possible.…”

Section: Quality Of Lifementioning

confidence: 99%

A systematic review and meta‐analysis of outcomes after elective surgery for ulcerative colitis

et al. 2020

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Aim Approximately 20%–30% of patients with ulcerative colitis (UC) will undergo surgery during their disease course, the vast majority being elective due to chronic refractory disease. The risks of elective surgery are reported variably. The aim of this systematic review and meta‐analysis is to summarize the outcomes after elective surgery for UC. Methods A systematic review was conducted that analysed studies reporting outcomes for elective surgery in the modern era (>2002). It was prospectively registered on the PROSPERO database (ref: CRD42018115513). Searches were performed of Embase and MEDLINE on 15 January 2019. Outcomes were split by operation performed. Primary outcome was quality of life; secondary outcomes were early, late and functional outcomes after surgery. Outcomes reported in five or more studies underwent a meta‐analysis of incidence using random effects. Heterogeneity is reported with I2, and publication bias was assessed using Doi plots and the Luis Furuya‐Kanamori index. Results A total of 34 studies were included (11 774 patients). Quality of life was reported in 12 studies, with variable and contrasting results. Thirteen outcomes (eight early surgical complications, five functional outcomes) were included in the formal meta‐analysis, all of which were outcomes for ileal pouch–anal anastomosis (IPAA). A further 71 outcomes were reported (50 IPAA, 21 end ileostomy). Only 14 of 84 outcomes received formal definitions, with high inter‐study variation of definitions. Conclusion Outcomes after elective surgery for UC are variably defined. This systematic review and meta‐analysis highlights the range of reported incidences and provides practical information that facilitates shared decision making in clinical practice.

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Section: Quality Of Lifementioning

confidence: 99%

A systematic review and meta‐analysis of outcomes after elective surgery for ulcerative colitis

et al. 2020

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“…Notably, the incidence of UC is lowest in developing countries, and highest in North America and Western Europe (4). At present, the incidence of UC in Central Europe and Eastern Europe is increasing; however, it is steadily decreasing in Western Europe and Scandinavia (5). UC was first identified in 1859, yet its etiology remains unclear.…”

Section: Introductionmentioning

confidence: 99%

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways

Yan

Sun

2017

Molecular Medicine Reports

149

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D-limonene has been demonstrated to have important immunomodulatory properties, including antitumor effects, and may alleviate asthma and allergies. In the present study, the anti‑inflammatory effects of D‑limonene were investigated in an ulcerative colitis (UC) rat model. Healthy male Sprague‑Dawley rats were randomly divided into control, untreated UC, and treatment with 50 or 100 mg/kg D‑limonene UC groups. In UC rats, disease activity and colonic mucosa damage were significantly reduced by the anti‑inflammatory effects of D‑limonene, via suppression of matrix metalloproteinase (MMP)‑2 and ‑9 gene expression. In addition, treatment with D‑limonene significantly increased antioxidant, inducible nitric oxide synthase (iNOS) and cyclooxygenase‑2 (COX‑2) protein expression levels in UC rats. A decrease in prostaglandin E2 (PGE2) production, transforming growth factor‑β (TGF‑β) gene expression and an increase phosphorylated‑extracellular signal regulated kinase (ERK) 1/2 expression levelswere observed in UC rats treated with D‑limonene. In conclusion, D‑limonene reduced MMP‑2 and ‑9 mRNA expression levels via regulation of the iNOS, COX‑2, PGE2, TGF‑β and ERK1/2 signaling pathways in a UC rat model, indicating its potential antioxidant and anti‑inflammatory properties.

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“…Comparisons of the quality of life of patients with regard to the different methods of surgery, pharmacology, and disease activity [21, 24, 26, 30, 32–34, 37–39, 41, 43, 46]. …”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life assessment among patients with inflammatory bowel diseases after surgery – review

Bączyk¹,

Formanowicz²,

Gmerek³

et al. 2017

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Aim of the work was to review systematically the published literature addressing whether quality of life (QoL) and health-related QoL (HRQoL) are influenced by surgery among patients with inflammatory bowel disease (IBD). Electronic databases and published articles were searched to identify relevant studies published in the years 1990–2015. Then, a multistep selection was undertaken to identify articles that met specific selection criteria, such us specific key-words (IBD, HRQoL, ulcerative colitis (UC), Crohn’s disease (CD), and surgery), and the population was assessed (studies concerning patients < 18 years old were excluded). The review included 27 studies that were evaluated in the context of the influence of surgery on QoL and HRQoL. Concluding, with the increase in the incidence of IBD, monitoring of QoL is an important indicator of the health effects at each stage of the surgical treatment.

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Evaluation of long‐term function, complications, quality of life and health status after restorative proctocolectomy with ileo neo rectal and with ileal pouch anal anastomosis for ulcerative colitis

Abstract: Comparison of INRA and RPC on an intention to treat basis was not considered to be realistic due to the high intra-operative conversion rate and the failures in the INRA group. RPC remains the procedure of choice for restoring intestinal continuity after proctocolectomy for UC.

Cited by 8 publications

References 33 publications

A systematic review and meta‐analysis of outcomes after elective surgery for ulcerative colitis

A systematic review and meta‐analysis of outcomes after elective surgery for ulcerative colitis

D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways

Health-related quality of life assessment among patients with inflammatory bowel diseases after surgery – review

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