Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy

Kuerten, David; Plange, Niklas; Becker, Jakob; Walter, Peter; Fuest, Matthias

doi:10.1097/ijg.0000000000000827

Cited by 12 publications

(13 citation statements)

References 18 publications

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“…The resolution offered by today's OCT imaging devices has allowed clinicians to identify aqueous humour outflow structures, including the SC, as already described by many authors in healthy adults or those with glaucoma (Kagemann et al 2010; Usui et al 2011;Shi et al 2012;Chen et al 2013;Hong et al 2013Hong et al , 2014Skaat et al 2016Skaat et al , 2017Rosman et al 2017;Kuerten et al 2018).…”

Section: Discussionmentioning

confidence: 94%

“…Currently, OCT is gaining popularity to assess the anterior chamber angle, and it is now possible to identify the various structures that make up the angle (Wong et al 2009;Bald et al 2012;Fern andez-Vigo et al 2015), specifically, the SC can be swiftly and accurately examined, as described by many authors (Kagemann et al 2010;Usui et al 2011;Shi et al 2012;Hong et al 2013). Interest in the study of the SC has recently mounted in an effort to understand the pathophysiology of aqueous humour drainage (Huang et al 2017) in glaucoma, or its behaviour in response to numerous treatments such as travoprost (Chen et al 2013), pilocarpine (Skaat et al 2016), cyclopentolate , trabeculoplasty , canaloplasty (Grieshaber et al 2017;Kuerten et al 2018), or trabeculectomy (Hong et al 2014). The study of angle structures such as the SC and TM is also attracting the attention of ophthalmologists in relation to the emerging field of minimally invasive glaucoma surgery (MIGS).…”

Section: Introductionmentioning

confidence: 99%

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Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants. Results Mean participant age was 10.7 ± 3.4 years (range 3–18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131–509) and 273.2 ± 77.3 μm (range 124–486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000–23 000) versus 9688 ± 3297 μm2 (range 3000–24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936). Conclusion FD‐OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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“…Knowledge about the degree of suture tensioning may be helpful in assessing the success of canaloplasty. Also, the amount of SC distention can be assessed post-operatively using anterior imaging techniques, such as high-resolution ultrasound biomicroscopy [4,40,[79][80][81][82] and anterior segment optical coherence tomography [77,81,83].…”

Section: Discussionmentioning

confidence: 99%

Changes in spectral parameters of corneal pulse following canaloplasty

Danielewska

Kicińska

Plaček

et al. 2019

Graefes Arch Clin Exp Ophthalmol

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Purpose To ascertain whether changes in the spectral content of the corneal pulse (CP) signal, measured in vivo in primary openangle glaucoma (POAG) patients, indirectly reflect changes in corneal biomechanics after canaloplasty. Methods Fifteen eyes of 15 POAG patients who underwent canaloplasty combined with phacoemulsification were enrolled. Standard ophthalmic examinations were conducted before washout, pre-operatively, at days 1, 7, and 1, 3, 6, and 12 months after surgery. Non-contact measurements of the CP signal were performed at pre-washout, pre-operatively, and at 3, 6, and 12 months post-operatively. Then, amplitudes of the CP first five harmonics associated with the heart rate were estimated. Temporal changes of all considered parameters were tested at a Bonferroni-adjusted significance level set to 0.005. Results A decrease in the amplitude of the first harmonic and an increase in the normalized amplitude of the third harmonic (A CP3n) of the CP signal were noticed between the pre-washout and the pre-operative stages (p = 0.003 and p = 0.004, respectively). This corresponds to an increase in median intraocular pressure (IOP) values by 6.0 mmHg (p = 0.0045). After surgery, A CP3n reached the highest value at 3 months post-operatively, compared with pre-washout level (p = 0.0045). Conclusions Alterations in corneoscleral stiffness caused by surgery are reflected in changes in the A CP3n value. Hence, postoperative corneal biomechanics could be monitored indirectly by this supporting indicator that can be used to estimate the time at which measures of IOP are no longer biased by the changed cornea boundary conditions caused by canaloplasty. Clinical Trials Registration NCT02908633

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“…All these anatomy concepts have found a great correspondence in the OCT imaging, so that the aspect of the conjunctiva in the OCT image presents typical features as shown in several reports [5][6][7][8][9][10]. The use of ASOCT on the normal conjunctiva is a complete and useful tool since the OCT imaging already provides a detailed representation of healthy limbus, sclera and conjunctiva.…”

Section: Normal Conjunctivamentioning

confidence: 96%

“…The evaluation of the postoperative effectiveness of glaucoma surgery is a well validated use of the anterior OCT [6,8,13].…”

Section: The Use Of Oct In Glaucomamentioning

confidence: 99%

OCT Applications in Conjunctival Disease

Piscopo¹,

Lanza²,

Mele³

et al. 2019

A Practical Guide to Clinical Application of OCT in Ophthalmology

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Today the of anterior segment optical coherence tomography (ASOCT) has become an irreplaceable tool in the management of various pathologies and also in many surgical techniques. The cornea has been widely studied in many pathologies with ASOCT, but now also the conjunctival study with ASOCT allows to obtain a detailed imaging of the normal and pathological conjunctiva, so that in many conjunctival diseases the ASOCT is a useful tool to help the clinicians. In this chapter we will briefly discuss the results of the imaging of the oct appearance of the normal conjunctiva with ASOCT and its present and potential use in the conjunctival pathologies.

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Evaluation of Long-term Anatomic Changes Following Canaloplasty With Anterior Segment Spectral-domain Optical Coherence Tomography and Ultrasound Biomicroscopy

Abstract: Persisting anatomic changes of SC, a transscleral filtration and a scleral lake can be recorded by AS-OCT and UBM long-term after successful canaloplasty.

Cited by 12 publications

References 18 publications

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Changes in spectral parameters of corneal pulse following canaloplasty

OCT Applications in Conjunctival Disease

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