2013
DOI: 10.1590/s0102-86502013001000004
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Evaluation of lipoic acid topical application on rats skin wound healing

Abstract: The topical application of lipoic acid produced an increase in the skin wound healing, which may be related to its pro-oxidant activity. On the other hand, the nanoencapsulation of the lipoic acid reversed the pro-oxidant activity, although presented minor healing activity.

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Cited by 9 publications
(5 citation statements)
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References 18 publications
(23 reference statements)
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“…Effective epidermal thickening has been confirmed in human skin after a treatment containing LPA applied for 6 months [ 18 ]. These positive effects of LPA reported in humans were also demonstrated by several animal studies [ 19 , 20 , 21 ], thus highlighting the role of LPA in improving several skin pathological conditions. Moreover, LPA is known for his strong antioxidant effects [ 22 ].…”
Section: Introductionsupporting
confidence: 68%
“…Effective epidermal thickening has been confirmed in human skin after a treatment containing LPA applied for 6 months [ 18 ]. These positive effects of LPA reported in humans were also demonstrated by several animal studies [ 19 , 20 , 21 ], thus highlighting the role of LPA in improving several skin pathological conditions. Moreover, LPA is known for his strong antioxidant effects [ 22 ].…”
Section: Introductionsupporting
confidence: 68%
“…Studies have shown that lipoic acid (LA) 29 , 18β-glycyrrhetinic acid (18β-GA) 30 and tretinoin act significantly in the repair of the dermis, increasing the number of fibroblasts and the collagen synthesis 8 . Such results were also observed after the use of collagenase and trans-retinoic acid 9 , 10 , as well as DPG.…”
Section: Discussionmentioning
confidence: 99%
“…Skin samples from the two wounded areas were immediately fixed in 4% (v/v) paraformaldehyde (PFA) for overnight at 4°C and later washed with 0.1 M phosphate buffered saline (PBS; pH 7.4). The skin specimens were processed for routine paraffin embedding protocol (Külkamp-Guerreiro et al, 2013;Perini et al, 2015), and histological analyses.…”
Section: Experimental Dermal Wound Healing In Ratsmentioning
confidence: 99%