Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease

Smith, Kara M.; Ash, Sharon; Xie, Sharon X.; Grossman, Murray

doi:10.1044/2018_jslhr-l-17-0304

Cited by 22 publications

(11 citation statements)

References 50 publications

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“…This pattern of increased errors within the OD category has been observed in other acquired neurological conditions, such as severe TBI, adults with developmental cluttering, and Parkinson’s disease (Power et al, 2020; Myers et al, 2012; Smith et al, 2018). Both Power and colleagues (2020) and Smith and colleagues (2018) have demonstrated in different populations that such errors are associated with cognitive deficits. Concussion is known to impact cognition, specifically executive functions, attention, and memory (Covassin & Elbin, 2012) that may result in the increased rate of interjections and other similar dysfluency types (e.g., fillers, pauses).…”

Section: Discussionsupporting

confidence: 65%

“…Interjections are defined as additional words or phrases that do not contribute to the sentence structure or meaning (e.g., so, you know, like) (Ambrose & Yairi, 1999). This pattern of increased errors within the OD category has been observed in other acquired neurological conditions, such as severe TBI, adults with developmental cluttering, and Parkinson's disease (Power et al, 2020;Myers et al, 2012;Smith et al, 2018). Both Power and colleagues (2020) and Smith and colleagues (2018) have demonstrated in different populations that such errors are associated with cognitive deficits.…”

Section: Discussionmentioning

confidence: 93%

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Fluency Changes due to Sports-Related Concussion

Patel

Grabowski

Dayalu

et al. 2021

Preprint

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Background: Alterations in speech have long been identified as indicators of various neurologic conditions including traumatic brain injury (TBI), neurodegenerative diseases, and stroke. TBIs that can be assessed using the Glasgow Coma Scale often result in speech symptoms such as dysarthria and occasionally neurogenic stuttering. The manifestation of symptoms including the specific changes in speech occurring in mild TBIs (or concussions) may differ from more severe head injuries. This work aims to compare speech fluency in sport-related concussion to baseline performance as well as non-athlete controls. Methods: A total of 230 Division I student athletes participated in pre-season speech testing. Of these, 12 students (18-22 years) who sustained a concussion also participated in speech testing in the days following diagnosis of concussion. Samples of picture descriptions were independently coded by three trained raters as 17 error types within the three traditional categories of errors defined in fluency analysis (Stuttering-Like Disfluency, Articulation Error, Other Disfluency). Results: Within-subjects analysis comparing the difference in percent error scores at baseline and post-concussion revealed significant differences for interjections (t(11)=-2.678, p< .05). The Other Disfluency category was also significantly different (t(11)= -2.735, p< .05), with more errors occurring after a concussion. No change in the Stuttering-Like Disfluency (t(11)= -0.799, p>.05) or Articulation Error category (t(11)=-0.045, p>.05) was found. Conclusions: These results demonstrate that speech changes occur following mild sports-related concussions. Specifically, the rate of interjections increased in a limited sample of college athletes who sustain a concussion. Changes in additional error types (fillers, pauses) were trending, but were not significant potentially due to the low sample size. Future studies should consider speech as a diagnostic tool for concussion.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 93%

Fluency Changes due to Sports-Related Concussion

Patel

Grabowski

Dayalu

et al. 2021

Preprint

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“…There was also an association with memory functioning, since word-finding saturates on both the amnestic and non-amnestic clusters, but word-finding seemed to be more closely related with WMSA than with the AD signature atrophy. Previous studies have linked word-finding with non-AD pathologies 49 and normal aging 50 in addition to AD 7 . Therefore, we suggest that the anomic cluster of complaints in this study could be related to cerebrovascular or mixed pathology (AD plus cerebrovascular pathology).…”

Section: Discussionmentioning

confidence: 99%

Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles

Diaz-Galvan

Ferreira

Cedrés

et al. 2021

Sci Rep

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Subjective cognitive decline (SCD) has been proposed as a risk factor for future cognitive decline and dementia. Given the heterogeneity of SCD and the lack of consensus about how to classify this condition, different operationalization approaches still need to be compared. In this study, we used the same sample of individuals to compare different SCD operationalization approaches. We included 399 cognitively healthy individuals from a community-based cohort. SCD was assessed through nine questions about memory and non-memory subjective complaints. We applied four approaches to operationalize SCD: two hypothesis-driven approaches and two data-driven approaches. We characterized the resulting groups from each operationalization approach using multivariate methods on comprehensive demographic, clinical, cognitive, and neuroimaging data. We identified two main phenotypes: an amnestic phenotype characterized by an Alzheimer’s Disease (AD) signature pattern of brain atrophy; and an anomic phenotype, which was mainly related to cerebrovascular pathology. Furthermore, language complaints other than naming helped to identify a subgroup with subclinical cognitive impairment and difficulties in activities of daily living. This subgroup also showed an AD signature pattern of atrophy. The identification of SCD phenotypes, characterized by different syndromic and biomarker profiles, varies depending on the operationalization approach used. In this study we discuss how these findings may be used in clinical practice and research.

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“…En su trabajo realizado en la Universidad Autónoma de Barcelona, Bobadilla determinó que al inicio de la enfermedad los síntomas cognitivos pueden ser definidos por molestias no relacionadas por parte del paciente, en su mayoría causados por fallo de inervación dopaminérgica, demostrando la importancia del estudio neuropsicológico en etapas tempranas como factor predictivo de demencia 18 .…”

Section: Deterioro Cognitivounclassified

Terapia de rehabilitación cognitiva, calidad de vida de pacientes con enfermedad de Parkinson y cuidadores.

Jiménez¹,

Ramírez

Romero

2021

Alerta

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La enfermedad de Parkinson es la segunda patología neurodegenerativa más recurrente, progresiva y crónica que perjudica a pacientes y cuidadores. Es fundamental describir la calidad de vida en pacientes y cuidadores posterior a la terapia de rehabilitación cognitiva. Por ello se elaboró un artículo de revisión mediante una búsqueda en bases de datos, PubMed, Google Scholar, SciELO, empleando artículos originales, ensayos clínicos, de revisión, entre otros, publicados en los últimos cinco años en español e inglés. El deterioro cognitivo en los pacientes de forma prematura conlleva a mayor riesgo de demencia, que se manifiesta con repercusión en las actividades de la vida diaria, como en la calidad de vida pacientecuidador. Mientras más avanzado se encuentre el estadio de la enfermedad, los pacientes con deterioro cognitivo generan mayor dependencia de sus cuidadores, empeorando la calidad de vida de ambos. La terapia de rehabilitación cognitiva pretende mejorar la calidad de vida de pacientes con enfermedad de Parkinson y sus cuidadores; actualmente se describen terapias de rehabilitación cognitiva basada en ejercicio físico. Al fortalecer la cognición mediante terapias de rehabilitación basadas en actividad física, el paciente presenta mayor independencia, lo cual disminuye la carga del cuidador, generandomayor empatía entre ambos.

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Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease

Abstract: https://doi.org/10.23641/asha.6615401.

Cited by 22 publications

References 50 publications

Fluency Changes due to Sports-Related Concussion

Fluency Changes due to Sports-Related Concussion

Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles

Terapia de rehabilitación cognitiva, calidad de vida de pacientes con enfermedad de Parkinson y cuidadores.

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