Evaluation of Lens Aldose Reductase Inhibitory and Free Radical Scavenging Potential of Fractions of Lonchocarpus cyanescens: Potential for Cataract Remediation

Ajani, Emmanuel Oladipo; Sabiu, Saheed; Odufuwa, Kuburat Temitope; Ibrahim, Taiwo Bashir; Salau, Bamidele Adewale

doi:10.5530/pj.2017.1.12

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Pin et al, 2010 have also reported the same trend. Our results could in part be due to other factors that lead to variation of yields for different solvents apart from the phytochemicals in plants, including extraction temperature, extraction time and solvent to solid ratio (Ajani et al, 2017). Oral glucose loading induces the physiological diabetes mellitus by raising blood glucose levels temporarily without damaging the pancreas (Singh and Pathak, 2015).…”

Section: Discussionmentioning

confidence: 99%

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2020

IBSPR

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This study aimed at screening for the hypoglycaemic efficacy and phytochemical(s) of Solanum terminale fruits, being used traditionally in Lushoto, Tanzania for management of diabetes and hypertension. S. terminale fruits were collected November 2018 in Lushoto. Hypoglycaemic efficacy testing of the crude ethanolic extract and factions of S. terminale fruits at 100 mg/kg body weight (BW) dose were carried out in healthy albino mice using Oral Glucose Tolerance Test (OGTT). The phytochemical screening based on the chemical reactions of the precipitation and coloration with the standard reagents was used. The statistical analysis of results was carried out using independent student's t-test (p ˂ 0.05). The crude ethanolic extract and fractions of S. terminale fruits at a dose of 100 mg/kg BW have demonstrated the significant blood glucose lowering efficacy, and the phytochemical screening indicated the presence of tannins, saponins, terpenoids, alkaloids, steroids, flavonoids and glycosides. Results of the study indicate the therapeutic potential of S. terminale fruits in the lowering of the blood glucose levels, but further studies are needed including toxicity and other animal models testing for diabetes.

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Section: Discussionmentioning

confidence: 99%

Untitled

2020

IBSPR

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“…Plant materials (roots, leaf, seed, bark, owers, etc.) have been reported to be used to treat and manage several diseases such as diabetes [6,7], hypertension [8], and cataracts [9]. Furthermore, several drugs used in conventional medicine were originally derived from plants.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation and In Silico Identification of Acetylcholinesterase Inhibitors in a Commercial Polyherbal Formulation (KWAPF01)

Aladodo

Ibrahim

Sabiu

2022

Evidence-Based Complementary and Alternative Medicine

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This study investigated the toxicological implications of a commercial polyherbal formulation, KWAPF01. Twenty-four Wistar rats were randomized into six groups of four animals per group. The animals in Group 1 were administered placebo and designated as control, while the rats in Groups 2 to 6 were administered 1000, 1500, 2000, 2500, and 3000 mg/kg bodyweight single oral dose of KWAPF01, respectively, and subsequently monitored for gross morphological and behavioural changes for 72 h. Piloerection, reduced motility, and tremor were observed in experimental groups, and the median lethal dose (LD50) of the extract was 2225.94 mg/kg bodyweight. The 11 compounds identified through HPLC analysis of the extract were docked against acetylcholinesterase (AChE), and the docking scores ranged from −5.3 to −10.8 kcal/mol, with catechol (−5.3 kcal/mol) and berberine (−10.8 kcal/mol) having the highest and lowest binding energies, respectively. Judging by the results, it could be inferred that some of the constituents of KWAPF01 have a direct impact on the nervous system and this is possibly elicited via the cholinergic system as it contains a nicotinic acetylcholine receptors agonist and potential inhibitors of AChE. Therefore, the use of KWAPF01 needs to be cautiously guided.

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